Focal lesions in the liver Flashcards

1
Q

What are the examinations for benign liver tumours?

A

US, CT, MRI, FNA

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2
Q

Which benign hepatic tumour has minimal bleeding risk?

A

Focal modular hyperplasia

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3
Q

Adenomas have a malignant risk due to ______ mutations and there is also a risk of _________.

A

oncogene

pain and bleeding

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4
Q

What are the types of cysts in the liver?

A

Simple

Hydatid

Abscesses

Polycystic liver disease

Von Meyenburg complexes

Autosomal dominant Polycystic Kidney disease

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5
Q

How do simple cysts present?

A

Usually asymptomatic but there is a risk of compression, hemmorharage, and infection

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6
Q

What should be done for simple cysts?

A

Imaging in 3-6 months

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7
Q

What are hydatid cysts caused by?

A

Echinoccocus granulosus

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8
Q

How should hydatid cysts be treated?

A

Conservative: cystectomy
Radical: lobectomy
Medical: Albendazole
Percutaneous Drainage

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9
Q

Which type of tumour is likely to cause hepatomegaly?

A

Polycystic liver disease

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10
Q

How is polycystic liver disease treated?

A

Usually treated to halt cyst growth
Somatostatin analogues
Aspiration
Liver transplantation

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11
Q

What should be done for abscesses?

A
  • echocardiogram
  • drainage
  • broad spectrum antibiotics
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12
Q

What are some malignant tumours of the liver?

A

Hepaticellular carcinoma
Fibrolamellar carcinoma
Hepatoblastoma
Metastasis

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13
Q

What are the treatments for malignant liver cancers?

A
  1. Transplant for small minimal tumours
  2. Resection for small tumours with reserved liver function
  3. TACE for early cirrhosis
  4. radio frequency ablation, ethanol injection
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14
Q

What is TACE?

A

Chemotherapy in the hepatic artery

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15
Q

How would hepatocellular carcinoma present?

A

Weight loss
AFP > 100 ng/ml
RUQ pain

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16
Q

How would Fibrolamellar carcinoma present?

A

AFP normal

Stellate scar on CT

17
Q

What staging is used for hepatocellular carcinomas?

A

Child’s Turcotte Pugh - ascites

MELD - bilirubin, creatinine, INR

18
Q

Which drug can be used to reduce blood supply to a tumour?

A

Sorafineb

19
Q

What metabolises ethanol to acetaldehyde?

A

ADH
Aldehyde
CYP2E1

20
Q

What are some of the adverse effects of acetaldehyde?

A

inflammation
hepatocyte death
stellate cell activation