Fischer Reproduction Test 3: Part 3

Question 1

Q37

Histologically, what kind of cancer is cancer of the penis?

Answer 1

• • Squamous cell carcinoma of the penis (98%)
• More common in uncircumcised men
• • Treatment: surgical amputation + radiation therapy.

Question 2

Q38:

What is the most characteristic feature of a herpes (herpesviruses) infection?

Answer 2

Vesicles
(if a question has to do with vesicles, the answer is always HERPES)
-latent state
Cytopathic effect (multi-nucleated giant cells with intranuclear inclusion bodies)

Question 3

Q39:

What is koilocytosis (Koilocytes) and what virus is it associated with?

Answer 3

• a virus that infects squamous epithelial cells and produces cytoplasmic vacuoles within cells.
• Associated with HPV (papillomavirus) –> Warts

Question 4

Q40:

What STI has a characteristic chancre vs vesicle

Answer 4

Chancre: primary syphilis
Vesicle: Herpes

Question 5

Q41:

What is Peyronie’s disease?

• What is its etiology
• Location

Answer 5

• Curved penis
• Dense dermal fibrosis with non-specific chronic inflammatory infiltrate and the collage slowly replaces muscle
• Etiology: unknown
  Location: Shaft of the penis

Question 6

Q42:

What does N. gonorrhea have so that it can attach itself to the urethral epithelium.
- How does it resist phagocytosis

Answer 6

• Pili
• Hydrolyzes host secretory IgA via IgA protease
• 3rd most common STD

Question 7

Q43:

What are the clinical features of primary syphilis

Answer 7

At site of inoculation –> spirochetes multiply and a local, non-tender ulcer called a CHANCRE usually forms in 2-10 weeks.
- Ulcer heals spontaneously, but spirochetes spread widely in tissues and 1-3 months later, secondary lesions may appear as a maculopapular rash, usually on the palms and soles, or as a moist papules on the skin and mucous membranes.

Question 8

Q43:

What are the clinical features of secondary syphilis

Answer 8

• Moist lesions on the genitals are called condylomata lata
• There may also be organ involvement resulting in a meningitis, nephritis or a hepatitis, these organ lesions are rich with spirochetes and are highly infectious
• Lymphadenopathy, arthritis, and fever
• All of these lesions will also spontaneously heal

Question 9

Q43:

What are the clinical features of tertiary syphilis

Answer 9

• occurs years after initial infection and often involves aorta (80-85%) w/ aneurysm formation or aortic regurgitation
• Can also involve the CNS resulting in neurosyphilis, from a chronic meningitis to Tabes Dorsali (spirochetal damage to the sensory nerves of the dorsal root resulting in ataxia, loss of pain sensation and absence of deep tendon reflexes

Question 10

Q44:

What is Trichomonoas Vaginalis?
- What is the characteristic look to the discharge?

Answer 10

• Transmitted sexually and if found in the female vagina and male urethra
• Pear-shaped w/ central nucleus and four anterior flagella.
• Characteristic: Causes a watery, foul-smelling greenish discharge accompanied by itching and burning.