first set HemeOnc MKSAP

Question 1

what are some symptoms of transfusion associated Graft vs Host disease?

Answer 1

fever

erythematous maculopapular rash-generalized

RUQ abd pain
Abnormal LFTs
hepatomegaly

profuse waterry diarrhea

Question 2

what is the solution to avoid Transfusion caused graft vs host?

Answer 2

irradiated blood (radiation that takes out T cells)

Question 3

pathophysiooyg behind transfsusion related graft vs host occur

Answer 3

Donor’s lymphocytes/T cells attack recipient

Question 4

how long after transfusion does reaction of tranfusion related graft vs host occur

Answer 4

4-30days after

Question 5

imaging in MM/smoldering/mgus to detect lytic lesions

Answer 5

start with CT-low dose->if nothing seen then do whole body MRI

Question 6

what is associated as cause of pure red cell aplasia

Answer 6

Parvo B19, thymoma,

Question 7

MOST appropriate first test for B12 deficiency

Answer 7

start: B12 level (TOTAL)

if level btwn 180-350->get Methylmalonic acid

if <180: deficiency
if >350: NO deficiency

Question 8

b12 def symptoms

Answer 8

glossitis

DCML symptoms: lack of vibration,proprioception,fine touch

fatigue(anemia)

dementia/hallucination

Question 9

what is seen on G6PD deficiency on peripheral smear

Answer 9

bite cells
blister cells

Question 10

special stains can show what for G6PD

Answer 10

Heinz bodies

Question 11

how does G6PD trigger/flare present?

what causes trigger?

Answer 11

trigger presentation: hemolysis
(from oxidative stress)

cause:
-Meds-Bactrim, nitrofurantoin, procainamide
-infections

Question 12

treatment for g6pd flareup

Answer 12

FIRST remove offending agent (ie drug)

NEXT if needed give rbc tranfusion

Question 13

what is the Triple Positive test for Antiphospholipid syndrom

Answer 13

triple positive means + for:

Cardiolipin ab
B-glycoprotein Ab
lupus anticoagulatn

Question 14

TREATMENT for thrombosis in Antiphospholipid syndr

Answer 14

LMWH bridge to Warfarin

NO DOAC!!! (higher risk of thrombosis)