3rd set HemeOnc MKSAP

Question 1

how to tx bone lytic lesions in MM

Answer 1

Bisphosphonates IV

Question 2

resistance to heparin for clot tx, consider….

Answer 2

antithrombin deficiency

Question 3

tx for mild hereditary spherocytosis

Answer 3

folate supplement

Mild meaning no splenomeg, symptomatic anemia, needing transfusions

Question 4

tx for severe hereditary spherocytosis

Answer 4

splenectomy

Question 5

Tx for CML

Answer 5

Imatinib

(tyrosine kinase inhibitor)

Question 6

role of antithrombin III

Answer 6

activate factor X and IX
inhibit thrombin(IIa)

Question 7

tx for aplastic anemia

Answer 7

hematopoetic stem cell transplant

Question 8

warfarin with supratheraputic INR 8.5, no bleed, Tx?

Answer 8

HOLD warfarin and obs

Question 9

warfarin with supratheraputic INR 10, no bleed, Tx?

Answer 9

HOLD warfarin and give PO VitK

Question 10

warfarin with supratheraputic INR 8.5, with bleed, Tx?

Answer 10

HOLD warfarin, give PCC and IV VitK

Question 11

rules of giving warfarin reversal in setting of supratheraputic INR

Answer 11

INR <10 and no bleed: hold and obs

INR >10 and no bleed: hold and PO vitK

INR >10 and bleed: Hold, PCC, IV VitK

INR <10 and bleed: Hold, PCC, IV VitK

Question 12

first test to evaluate thrombocytopenia

Answer 12

Peripheral blood smear
to see if real thrombocytopoenia or pseudo (sometimes plts clump causing pseudo)

Question 13

peripheral blood smear will show this for warm agglutination

Answer 13

spherocytes

Question 14

bite cells on peripheral smear

Answer 14

G6PD deficiency