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Pharmacology > First Aid 2014-Therapeutic Antibodies > Flashcards

First Aid 2014-Therapeutic Antibodies Flashcards

0
Q

What is the target and clinical use of cetuximab?

A

EGFR-
Stage 4 colorectal cancer-
Head and neck cancer

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1
Q

What is the target and clinical use of Alemtuzumab?

A

CD52

CLL

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2
Q

What is the target and clinical use of Bevacizumab?
Mechanism?
Side effect?

A 
Monoclonal ab against VEGF-
Inhibit angiogenesis-
Colorectal cancer-
Renal cell carcinoma-
Hemorrhage -
 impaired Wound healing
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4
Q

What is the target and clinical use of Rituximab?
Mechanism?
Side effect?

A 
Monoclonal AB against CD20-
B cell nonhodgkin lymphoma-
Rheumatoid Arthritis (with MTX)-
ITP-
Increase risk of Progressive multifocal Leukoencephalopathy
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4
Q

What is the target and clinical use of infliximab and adalimumab?

A 
TNF alfa
IBD
Rheumatoid Arthritis
Ankylosing Spondylitis
Psoriasis
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5
Q

What is the target and clinical use of Trastuzumab (Herceptin)? Side effect?

A

HER2/neu (Tyrosine Kinase receptor)
Breast cancer
Gastric Cancer
Cardiotoicity

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6
Q

What is the target and clinical use of Natalizumab?

What is the risk for patients with JC virus?

A

Alfa4-integrin : leukocyte adhesion
MS
Crohn Disease
Risk of PML in patients with JC virus

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7
Q

What is the target and clinical use of Denosumab?

Mechanism?

A

RANKL
Osteoporosis
Inhibit osteoclast maturation (mimic osteoprotegrin)

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8
Q

What is the target and clinical use of Abciximab?
What does it contain?
What is the side effect?

A 
Glycoprotein 2b/3a
Anti platelet agent in pt undergoing percutaneous coronary intervention
Monoclonal Ab Fab fragments
Bleeding 
Thrombocytopenia
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9
Q

What is the target and clinical use of Digoxin immune Fab?

A

Digoxin

Antidote for digoxin toxicity

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10
Q

What is the target and clinical use of Omalizumab?

Mechanism?

A

IgE
Allergic Asthma
Prevent IgE binding to Fc mu RI

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11
Q

What is the target and clinical use of Palivizumab?

A

RSV F Protein

RSV prophylaxis for high risk infants

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Pharmacology (12 decks)

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