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Pharmacology > Drug Reactions > Flashcards

Drug Reactions Flashcards

0
Q

What are the causal agents of cutaneous flushing? 4

A

Vancomycin
Adenosine
Niacin
Calcium channel blockers

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1
Q

What are the causal agents of coronary vasospasm? 3

A

Cocaine
Sumatriptan
Ergot alkaloids

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2
Q

What are the causal agents of dilated cardiomyopathy? 2

A

Doxorubicin

Daunorubicin

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3
Q

What are the causal agents of torsades de pointes? 5

A 
Class 3 antiarrythmics (Sotalol)
Class 1A (Quinidine)
Macrolides
Antipsychotics
TCAs
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4
Q

What are the causal agents of adrenocortical insufficiency? 1

A

Glucocorticoid withdrawal

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5
Q

What are the causal agents of hot flashes? 2

A

Tamoxifen

Clomiphene

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6
Q

What are the causal agents of hyperglycemia? 6

A 
Tacrolimus
Protease inhibitors
Niacin
HCTZ
Beta blockers
Corticosteroids
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7
Q

What are the causal agents of hypothyroidism? 3

A

Lithium
Amiodarone
Sulfonamides

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8
Q

What are the causal agents of acute cholestatic hepatitis, jaundice? 1

A

Erythromycine

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9
Q

What are the causal agents of diarrhea? 5

A 
Metformin
Erythromycin 
Colchicine
Orlistat
Acarbose
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10
Q

What are the causal agents of focal to massive hepatic necrosis? 4

A

Halothane
Amanita phalloides (death cap mushroom)
Valproic acid
Acetaminophen

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11
Q

What are the causal agents of hepatitis? 1

A

INH

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12
Q

What are the causal agents of pancreatitis? 6

A 
Didanosine
Corticosteroids
Alcohol
Valproic acid
Azathioprine
Diuretics (furosemide, HCTZ)
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13
Q

What are the causal agents of pseudomembranous colitis? 3

A

Antibiotics like :
Clindamycin
Ampicillin
Cephalosporins

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14
Q

What are the causal agents of agranulocytosis? 6

A 
Dapsone
Clozapine
Carbamazepine
Colchicine
Methimazole
PTU
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15
Q

What are the causal agents of aplastic anemia? 6

A 
Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
PTU
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16
Q

What are the causal agents of direct coombs positive hemolytic anemia? 2

A

Methyldopa

Penicillin

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17
Q

What are the causal agents of gray baby syndrome? 1

A

Chloramphenicol

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18
Q

What are the causal agents of hemolysis in G6PD deficiency? 7

A 
INH
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofourantoin
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19
Q

What are the causal agents of megaloblastic anemia?3

A

Phenytoin
Methotrexate
Sulfa drugs

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20
Q

What are the causal agents of thrombotic complications? 1

A

OCPs (estrogens)

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21
Q

What are the causal agents of thrombocytopenia? 2

A

Heparin

Cimetidine

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22
Q

What are the causal agents of fat redistribution? 2

A

Protease Inhibitors

Glucocorticoid

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23
Q

What are the causal agents of Gingival Hyperplasia? 4

A

Phenytoin
verapamil
cyclosporine
Nifedipine

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24
Q

What are the causal agents of hyperuricemia? 5

A 
Pyrazinamide
Thiazides
Furosemide
Niacin
Cyclosporine
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25
Q

What are the causal agents of Myopathy? 8

A 
Fibrates
Niacin
Colchicine
Hydroxychloroquine
IFN alfa
Penicillamine
Statins
Glucocorticoids
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26
Q

What are the causal agents of osteoporosis? 2

A

Corticosteroids

Heparin

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27
Q

What are the causal agents of Rash (Stevens Johnson Syndrome)? 8

A

Anti epileptic Drugs: Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital
Allopurinol
Sulfa Drugs
Penicillin

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28
Q

What are the causal agents of SLE-Like Syndrome? 6

A 
Sulfa Drugs
Hydralazine
INH
Procainamide
Phenytoin
Etanercept
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29
Q

What are the causal agents of teeth discoloration? 1

A

Tetracycline

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30
Q

What are the causal agents of tendonitis, tendon rupture, cartilage damage?

A

Fluoroquinolones

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31
Q

What are the causal agents of cinchonism? 2

A

Quinidine

Quinine

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32
Q

What are the causal agents of Parkinson like syndrome? 3

A

Antipyschotics
Metoclopramide
Reserpine

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33
Q

What are the causal agents of seizures? 6

A 
INH (Vitamin B6 def)
Bupropion
Imipenem/Cilastatin
Tramadol
Enflurane
Metoclopramide
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34
Q

What are the causal agents of Tardive Dyskinesia? 2

A

Antipsychotics

Meoclopramide

35
Q

What are the causal agents of DI? 2

A

Lithium

Demeclocycline

36
Q

What are the causal agents of Fancony Syndrome? 1

A

Expired tetracycline

37
Q

What are the causal agents of hemorrhagic Cystitis? 2

How to prevent it?

A

Cyclophosphamide
Ifosfamide
prevent by coadministration with Mesna

38
Q

What are the causal agents of interestitial nephritis? 3

A

Methicillin
NSAIDs
Furosemide

39
Q

What are the causal agents of SIADH? 3

A

Carbamazepine
Cyclophosphamide
SSRIs

40
Q

What are the causal agents of dry cough? 1

A

ACE Inhibitors

41
Q

What are the causal agents of pulmonary fibrosis? 4

A

Bleomycine
Amiodarone
Busulfan
Methotrexate

42
Q

What are the causal agents of antimuscarinic effects? 4

A

Atropine
TCAs
H1-Blockers
antipsychotics

43
Q

What are the causal agents of Disulfiram like reactions? 5

A 
Metronidazole
Certain cephalosporins
Griseofulvin
Procarbazine
1st-generation sulfonylureas
44
Q

What are the causal agents of Nephrotoxicity/Ototoxicity? 4

A

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin

45
Q

What are the c P-450 Inducers? 9

A 
Chronic alcohol use
Modafinil
St. John's Wort
Phenytoin
Phenobarbital
nevirapine
Rifampin
Griseofulvin
Carbamaepin
46
Q

What are the c P-450 substrates? 8

A 
Anti epileptics
Antidepressants
Antipsychotics
Anesthetics
Theophylline
Warfarin
Statins
OCPs
47
Q

What are the c P-450 Inhibitors? 12

A 
Acute alcohol abuse
Gemfibrozil
Ciprofloxacin
Isoniaid
Grape fruit juice
Quinidine
Amiodarone
Ketoconazole
macrolides
Sulfonamides
Cimetidine
Ritonavir
48
Q

What are the sulfa Drugs? 8

A 
Proobenecid
Furosemide
Acetazolamide
celecoxib
Thiazide
Sulfonamide AB
Sulfasalazine
Sulfonylureas
49
Q

What are the symptoms of sulfa allergies? 7

A 
Fever
UTI
Stevens Johnson syndrome
Hemolytic Anemia
Thrombocytopenia
Agranulocytosis
Urticaria (Hives)
51
Q

Atropine-like side effects

A

Tricyclics

52
Q

Coronary vasospasm

A

Cocaine, sumatriptan

53
Q

Cutaneous flushing

A

Niacin, Ca2+ channel blockers, adenosine, vancomycin

54
Q

Dilated cardiomyopathy

A

Doxorubicin (Adriamycin), daunorubicin

55
Q

Torsades des pointes

A

Class III (sotalol), class IA (quinidine) antiarrhythmics, cisapride

56
Q

Agranulocytosis

A

Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole

57
Q

Aplastic anemia

A

Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

58
Q

Direct Coombs-positive hemolytic anemia

A

Methyldopa

59
Q

Gray baby syndrome

A

Chloramphenicol

60
Q

Hemolysis in G6PD-deficient patients

A

Isoniazid (INH), Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

61
Q

Thrombotic complications

A

OCPs (e.g., estrogens and progestins)

62
Q

Cough

A

ACE inhibitors (note: ARBs like losartan–no ???)

63
Q

Pulmonary fibrosis

A

Bleomycin, busulfan, amiodarone

64
Q

Acute cholestatic hepatitis

A

Macrolides

65
Q

Focal to massive hepatic necrosis

A

Halothane, valproic acid, acetaminophen, Amanita phalloides

66
Q

Hepatitis

A

INH

67
Q

Pseudomembranous colitis

A

Clindamycin, ampicillin

68
Q

Adrenocortical insufficiency

A

Glucocorticoid withdrawal (HPA suppression)

69
Q

Gynecomastia

A

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole

70
Q

Hot flashes

A

Tamoxifen, clomiphene

71
Q

Gingival hyperplasia

A

Phenytoin

72
Q

Gout

A

Furosemide, thiazides

73
Q

Osteoporosis

A

Corticosteroids, heparin

74
Q

Photosensitivity

A

Sulfonamides, Amiodarone, Tetracycline

75
Q

SLE-like syndrome

A

Hydralazine, INH, Procainamide, Phenytoin

76
Q

Tendonitis, tendon rupture, and cartilage damage (kids)

A

Fluoroquinolones

77
Q

Fanconi’s syndrome

A

Expired tetracycline

78
Q

Interstitial nephritis

A

Methicillin, NSAIDs

79
Q

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide (prevent by coadministrating with mesna)

80
Q

Cinchonism

A

Quinidine, quinine

81
Q

Diabetes insipidus

A

Lithium, demeclocycline

82
Q

Seizures

A

Bupropion, imipenem/cilastatin

83
Q

Tardive dyskinesia

A

Antipsychotics

84
Q

Disulfiram-like reaction

A

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas reaction

85
Q

Nephrotoxicity/neurotoxicity

A

Polymyxins

86
Q

Nephrotoxicity/ototoxicity

A

Aminoglycosides, loop diuretics, cisplatin

87
Q

Which drugs cause gynecomastia? 7

A 
Spironolactone
Ketoconazole
Chronic alcohol use
Cimetidine
Estrogen
Digoxine
Marijuana

Pharmacology (12 decks)

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