Drug Reactions Flashcards
What are the causal agents of cutaneous flushing? 4
Vancomycin
Adenosine
Niacin
Calcium channel blockers
What are the causal agents of coronary vasospasm? 3
Cocaine
Sumatriptan
Ergot alkaloids
What are the causal agents of dilated cardiomyopathy? 2
Doxorubicin
Daunorubicin
What are the causal agents of torsades de pointes? 5
Class 3 antiarrythmics (Sotalol) Class 1A (Quinidine) Macrolides Antipsychotics TCAs
What are the causal agents of adrenocortical insufficiency? 1
Glucocorticoid withdrawal
What are the causal agents of hot flashes? 2
Tamoxifen
Clomiphene
What are the causal agents of hyperglycemia? 6
Tacrolimus Protease inhibitors Niacin HCTZ Beta blockers Corticosteroids
What are the causal agents of hypothyroidism? 3
Lithium
Amiodarone
Sulfonamides
What are the causal agents of acute cholestatic hepatitis, jaundice? 1
Erythromycine
What are the causal agents of diarrhea? 5
Metformin Erythromycin Colchicine Orlistat Acarbose
What are the causal agents of focal to massive hepatic necrosis? 4
Halothane
Amanita phalloides (death cap mushroom)
Valproic acid
Acetaminophen
What are the causal agents of hepatitis? 1
INH
What are the causal agents of pancreatitis? 6
Didanosine Corticosteroids Alcohol Valproic acid Azathioprine Diuretics (furosemide, HCTZ)
What are the causal agents of pseudomembranous colitis? 3
Antibiotics like :
Clindamycin
Ampicillin
Cephalosporins
What are the causal agents of agranulocytosis? 6
Dapsone Clozapine Carbamazepine Colchicine Methimazole PTU
What are the causal agents of aplastic anemia? 6
Carbamazepine Methimazole NSAIDs Benzene Chloramphenicol PTU
What are the causal agents of direct coombs positive hemolytic anemia? 2
Methyldopa
Penicillin
What are the causal agents of gray baby syndrome? 1
Chloramphenicol
What are the causal agents of hemolysis in G6PD deficiency? 7
INH Sulfonamides Dapsone Primaquine Aspirin Ibuprofen Nitrofourantoin
What are the causal agents of megaloblastic anemia?3
Phenytoin
Methotrexate
Sulfa drugs
What are the causal agents of thrombotic complications? 1
OCPs (estrogens)
What are the causal agents of thrombocytopenia? 2
Heparin
Cimetidine
What are the causal agents of fat redistribution? 2
Protease Inhibitors
Glucocorticoid
What are the causal agents of Gingival Hyperplasia? 4
Phenytoin
verapamil
cyclosporine
Nifedipine
What are the causal agents of hyperuricemia? 5
Pyrazinamide Thiazides Furosemide Niacin Cyclosporine
What are the causal agents of Myopathy? 8
Fibrates Niacin Colchicine Hydroxychloroquine IFN alfa Penicillamine Statins Glucocorticoids
What are the causal agents of osteoporosis? 2
Corticosteroids
Heparin
What are the causal agents of Rash (Stevens Johnson Syndrome)? 8
Anti epileptic Drugs: Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital
Allopurinol
Sulfa Drugs
Penicillin
What are the causal agents of SLE-Like Syndrome? 6
Sulfa Drugs Hydralazine INH Procainamide Phenytoin Etanercept
What are the causal agents of teeth discoloration? 1
Tetracycline
What are the causal agents of tendonitis, tendon rupture, cartilage damage?
Fluoroquinolones
What are the causal agents of cinchonism? 2
Quinidine
Quinine
What are the causal agents of Parkinson like syndrome? 3
Antipyschotics
Metoclopramide
Reserpine
What are the causal agents of seizures? 6
INH (Vitamin B6 def) Bupropion Imipenem/Cilastatin Tramadol Enflurane Metoclopramide
What are the causal agents of Tardive Dyskinesia? 2
Antipsychotics
Meoclopramide
What are the causal agents of DI? 2
Lithium
Demeclocycline
What are the causal agents of Fancony Syndrome? 1
Expired tetracycline
What are the causal agents of hemorrhagic Cystitis? 2
How to prevent it?
Cyclophosphamide
Ifosfamide
prevent by coadministration with Mesna
What are the causal agents of interestitial nephritis? 3
Methicillin
NSAIDs
Furosemide
What are the causal agents of SIADH? 3
Carbamazepine
Cyclophosphamide
SSRIs
What are the causal agents of dry cough? 1
ACE Inhibitors
What are the causal agents of pulmonary fibrosis? 4
Bleomycine
Amiodarone
Busulfan
Methotrexate
What are the causal agents of antimuscarinic effects? 4
Atropine
TCAs
H1-Blockers
antipsychotics
What are the causal agents of Disulfiram like reactions? 5
Metronidazole Certain cephalosporins Griseofulvin Procarbazine 1st-generation sulfonylureas
What are the causal agents of Nephrotoxicity/Ototoxicity? 4
Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin
What are the c P-450 Inducers? 9
Chronic alcohol use Modafinil St. John's Wort Phenytoin Phenobarbital nevirapine Rifampin Griseofulvin Carbamaepin
What are the c P-450 substrates? 8
Anti epileptics Antidepressants Antipsychotics Anesthetics Theophylline Warfarin Statins OCPs
What are the c P-450 Inhibitors? 12
Acute alcohol abuse Gemfibrozil Ciprofloxacin Isoniaid Grape fruit juice Quinidine Amiodarone Ketoconazole macrolides Sulfonamides Cimetidine Ritonavir
What are the sulfa Drugs? 8
Proobenecid Furosemide Acetazolamide celecoxib Thiazide Sulfonamide AB Sulfasalazine Sulfonylureas
What are the symptoms of sulfa allergies? 7
Fever UTI Stevens Johnson syndrome Hemolytic Anemia Thrombocytopenia Agranulocytosis Urticaria (Hives)
Atropine-like side effects
Tricyclics
Coronary vasospasm
Cocaine, sumatriptan
Cutaneous flushing
Niacin, Ca2+ channel blockers, adenosine, vancomycin
Dilated cardiomyopathy
Doxorubicin (Adriamycin), daunorubicin
Torsades des pointes
Class III (sotalol), class IA (quinidine) antiarrhythmics, cisapride
Agranulocytosis
Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole
Aplastic anemia
Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
Direct Coombs-positive hemolytic anemia
Methyldopa
Gray baby syndrome
Chloramphenicol
Hemolysis in G6PD-deficient patients
Isoniazid (INH), Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Thrombotic complications
OCPs (e.g., estrogens and progestins)
Cough
ACE inhibitors (note: ARBs like losartan–no ???)
Pulmonary fibrosis
Bleomycin, busulfan, amiodarone
Acute cholestatic hepatitis
Macrolides
Focal to massive hepatic necrosis
Halothane, valproic acid, acetaminophen, Amanita phalloides
Hepatitis
INH
Pseudomembranous colitis
Clindamycin, ampicillin
Adrenocortical insufficiency
Glucocorticoid withdrawal (HPA suppression)
Gynecomastia
Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole
Hot flashes
Tamoxifen, clomiphene
Gingival hyperplasia
Phenytoin
Gout
Furosemide, thiazides
Osteoporosis
Corticosteroids, heparin
Photosensitivity
Sulfonamides, Amiodarone, Tetracycline
SLE-like syndrome
Hydralazine, INH, Procainamide, Phenytoin
Tendonitis, tendon rupture, and cartilage damage (kids)
Fluoroquinolones
Fanconi’s syndrome
Expired tetracycline
Interstitial nephritis
Methicillin, NSAIDs
Hemorrhagic cystitis
Cyclophosphamide, ifosfamide (prevent by coadministrating with mesna)
Cinchonism
Quinidine, quinine
Diabetes insipidus
Lithium, demeclocycline
Seizures
Bupropion, imipenem/cilastatin
Tardive dyskinesia
Antipsychotics
Disulfiram-like reaction
Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas reaction
Nephrotoxicity/neurotoxicity
Polymyxins
Nephrotoxicity/ototoxicity
Aminoglycosides, loop diuretics, cisplatin
Which drugs cause gynecomastia? 7
Spironolactone Ketoconazole Chronic alcohol use Cimetidine Estrogen Digoxine Marijuana