Final pearls Flashcards
Antidepressants w evidence for superior efficacy
CANMAT 2016:
2nd gen antidepressant superiority:
- Escitalopram (level 1)
- Mirtazapine (level 1)
- Sertraline (level 1)
- Venlafaxine (level 1)
- Agomelatine (level 2) Citalopram (level 2)
susceptibility vs heritability
susceptibility = risk of presenting the phenotype when having the gene (genotype)
Heritability = part of responsibility of genes in a disease
Regina vs Taylor (Ontario 1992)
for fitness to stand trial
“limited cognitive capacity test”
- understand nature
-understand consequences of charges
-able to communicate w lawyer
-able to distinguish possible pleas (guilty vs non guilty)
-able to identify court protagonists
Article 16
Definition of “on criminally responsible”
M’Naghten criteria (1843)
for NCR
3 criteria:
1- having a mental disorder
AND
2- Capacity to appreciate nature/quality of act committed
OR
3- capacity to differentiate right from wrong (morally and legally)
What are the NCR Criteria
What are they called and what article of the criminal code
Article 16
M’Naghten criteria (1843)
3 criteria:
1- having a mental disorder
AND
2- Capacity to appreciate nature/quality of act committed
OR
3- capacity to differentiate right from wrong (morally and legally)
DBS target site
subcallosal cingulate cortex
- Aka Brodmann area 25, subgenual cingulate cortex, or Cg25
Pillars of existential psychotherapy
Mnemonic FIDM
Givens:
1- Freedom
2- Isolation
3- Death
Meaninglessness
Broca - neuroanat location
Left inferior frontal gyrus (of PFC)
Wernicke - neuroanat location
Superior temporal gyrus of left hemisphere
Elderly suicide methods
completed vs attempts
Suicide methods in elderly:
Completed suicides:
1- hanging
2- Firearms
3- Rx intox
Failed attempts
1- Rx intox
Lacerations
Schizophrenia genetic transmission
MZ twin
2 parents affected
DZ twin
One parent affected
1st degree relative (siblings)
2nd degree relative
3rd degree relative
- MZ twin: 47%
- 2 parents affected: 40%
- DZ twins: 12%
- One parent affected: 12%
- 1st degree relative (siblings): 8% (RR 9-18)
- 2nd degree relative - RR 3-6
3rd degree relative - RR 2-3
most frequent site of DBS
subcallosal cingulate cortex
other targets: ventral capsule/striatum, nucleus accumbens, anterior limb of internal capsule, medial forebrain bundle
