CYP 2 Flashcards by Rouan Gaffar

Q

Buspirone substrate

A

CYP 3A4 (grapefruit)

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Q

Beta blockers

Propanolol

A

2D6 substrate

Propanolol: substrate 2D6, 1A2, 2C19

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Q

Warfarin

A

1A2 substrate
2C19 substrate
2C9 substrate

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Q

Methadone

A

substrate: 3A4, 2B6 mostly, 2D6 minor

PPN - substrate: 2D6, 1A2

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Q

Oral contraceptives

A

Substrate: 3A4

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Q

Carbamazepine

A

Substrate 3A4
UNIVERSAL inducer (esp 3A4, 2D6, 2C19)

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Q

Phenytoin

A

Universal inducer
Substrate: 2C9

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Q

Rifampin

A

Universal Inducer

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Q

Phenobarbital

A

Inducer: 2D6, 1A1, 2C9

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Q

Grapefruit juice

A

CYP3A4 inhibitor

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Q

Antifungals (ketoconazole, itraconazole, fluconazole)

A

3A4 inhibitor

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Q

Clarithromycin, erythromycin

A

Inhibitor of 3A4

all macrolides except azithromycin

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Q

Amiodarone

A

Inhibitor: 1A2, 2D6, 3A4, 2C9

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Q

St John’s Wort

A

Inducer CYP3A4

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Q

Haldol

A

Substrate: 2D6, 1A2, 3A4

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Q

Olanzapine

A

Substrate: 1A2, 2D6

Q

Risperidone

A

Substrate: 1A2, 2D6

Q

Clozapine

A

Substrate: 3A4, 1A2

Q

Aripiprazole

A

Substrate 2D6, 3A4

Q

Duloxetine

A

Substrate: 2D6
Inhibitor: 2D6

Q

Topiramate

A

Inhibitor: 2C19
Substrate: 2C19