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RC Pearls > CYP interactions > Flashcards

CYP interactions Flashcards

1
Q

Fluvoxamine

A

Strong inhibitor *1A2 /2C19
Mod inhibitor 2C9/ 2D6 / *3A4

Substrate: 2D6, 1A2

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2
Q

Fluoxetine
Norfluoxetine

A

FLUOXETINE:
Strong inhibitor 2D6
substrate: 2D6

NORFLUOXETINE (active metabolite)
Mod inhibitor 3A4

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3
Q

Paroxetine

A

Strong inhibitor *2D6
Weak inhibitor *2C9 and 2C19
Substrate: 2D6

note* carbamazepine reduces paroxetine levels by 28%

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4
Q

Sertraline

A

Mod inhibitor 2D6
Substrate: 3A4, 2D6, 2C19, 2C9

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5
Q

Citalopram, Escitalopram

A

Substrate: 2C19

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6
Q

Venlafaxine
Desvenlafaxine

A

Venlafaxine:
Mild inhibitor 2D6
Substrate: 3A4, 2D6

Desvenlafaxine: active metabolite, not metabolized by 2D6

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7
Q

Duloxetine

A

moderate inhibitor 2D6
Substrate: 2D6

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8
Q

Buproprion

A

Mod inhibitor 2D6

Substrate: 2B6 (not D)

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9
Q

Mirtazapine

A

Substrate: 2D6, 3A4, and (lesser extent) 1A2

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RC Pearls (2 decks)

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