FINAL - Larval Tapeworms Flashcards
Extraintestinal Larval Tapeworms
Diphyllobothrium
Taenia solium
E. granulosus and E. multilocularis
Human Sparganosis
is caused by plerocercoid larvae of the genus Spirometra
In human sparganosis the infective stage is:
Which are found in:
Procercoid
the cyclops
Human sparganosis is widespread in _____, also found in _______
the Orient
all other continents
Spirometra is synonymous with
Diphyllobthrium
Sparganosis infection after ingestion of copepod
Inside the copepod’s gut, procercoids enter the gut wall of the host and migrate to various tissues, where they become large plerocercoids
Most common route of infection of sparganosis:
Humans also become infected with sparganosis by ingesting:
drinking water contaminated with cyclops copepods
raw or undercooked fish, amphibians, reptiles, birds, or even mammals
Most cases of sparganosis in the Orient are caused by _____, a tapeworm of _____
D. erinacei
carnivores
In N. America, the most common causative plerocercoid is that of _______, a tapeworm of ____
D. mansonoides
cats
In Human sparganosis, Once an infected animal is eaten,
the spargana wander in the deep tissues and migrate to the eyes, muscles, thorax, abdomen, thighs and cause many pathological conditions
Cerebral sparganosis
Some sparganosis infections of subdermal tissues can result in
painful “lumps” that might be misdiagnosed as cancer
diagnosis of sparganosis
Detection of the parasite in the host’s tissue
_______ removal of the larva is the most dependable treatment in ______
Surgical
Sparganosis
Drug of choice treating sparganosis
Praziquantel
____and ____ may accompany sparganosis infections
Chills and Fever
Prevention and Control of sparganosis
Proper cooking of freshwater fishes or other animals prior to eating is strongly recommended
Water should be consumed after boiling or filtering
Application of animal flesh to human skin should be avoided
Human Cysticercosis caused by
Taenia Solium
Common sites of human cysticercosis:
subcutaneous connective tissues, eyes, brain, muscles, heart, liver, lungs, and coelom.
Infection with cysticercosis occurs when
embryonated eggs pass through the stomach and hatch in the intestine
Gravid proglottid may migrate from the lower intestine to the stomach or duodenum, or it may be carried by reverse peristalsis (internal autoinfection).
Release and hatching of many eggs at the same time results in a massive infection by cysticercus.
Reverse peristalsis referred to as
Internal auto-infection
Common symptoms of human cysticercosis:
Muscle spasms and weakness, generalized fatigue, headache, paralysis, vomiting
When a cysticercus dies, it elicits
a severe inflammatory response
_______ of the cyst may occur after 1 year, after which time the disease may become _______.
Calcification
asymptomatic
When cysticerci infect the brain:
Neurocysticercosis
Often fatal
Dx of cysticercosis:
observing & feeling subcutaneous nodules and diagnosis confirmed by biopsy
X-rays can detect cysts that are calcified
CT scan determines any brain damage
recommended treatment for cysticerci infection
Surgery
Praziquantel or Albendazole
Developing cysticercus in the ____ may be mistaken for a _______, resulting in the unnecessary surgical removal of the eye
retina
malignant tumor
Care must be taken during treatment for adult worms to avoid causing severe ______, b/c:
Vomiting
it may induce internal auto-infection
Prevention of cysticercosis:
thoroughly wash salad vegetables
pay attention to personal hygiene and sexual habits and environmental sanitation
Drinking boiled or filtered water
avoidance of salads and raw fruits and vegetables in endemic areas
Control of cysticercosis:
sanitary disposal of feces
inspection of pork
_______ is probably the most common parasitic infestation of the human nervous system
Cysticercosis
Tapeworm infestation can occur only in _______, but cysticercosis may also occur in _______
nonvegetarians
vegetarians
Tapeworm infestation occurs via consumption of ______ where as cysticercosis occurs by consumption of _____
Infected meat
Eggs
Hydatid Disease caused by 2 spp:
Echinococcus granulosus
E. multilocularis
Echinococcus granulosus causes:
cystic echinococcosis in humans, with few large cysts
E. multilocularis causes:
alveolar echinococcosis with many small cysts, causing liver cancer
Defintive hosts for Echinococcus
Foxes, coyotes, dogs, cats
Intermediate hosts for Echinococcus
rodents, sheep, cattle, swine
smallest tapeworms
Echinococcus
Strobila contains only ____ proglottids: ____ ____ and ____
3
immature, mature and gravid
Scolex of Echinococcus:
Armed rostellum with 4 suckers
In Echinococcus, humans are an _______ host
Accidental
Humans are often infected with Echinococcus as a result of:
fondling dogs, via ingesting eggs by putting contaminated fingers into the mouth, or by eating raw plants contaminated with feces from infected cats, dogs, and other carnivores
Echinococcus life cycle
Eggs consumed by humans or intermediate host
Hatch into oncosphere in SI
Oncosphere penetrates intestinal wall and travels to other parts of the body becoming lodged in capillary beds of many organs where hydatid cysts begin to develop
Organs that are impacted by Echinococcus
liver, lung, kidney, spleen, heart, muscles, brain, bone marrow
Hydatid cysts contain
protoscolices
Infective stage in definitive host
Protoscolices
Infective stage in humans
Eggs
After _______, Protoscolices attach to _________ and develops into _____
Ingestion
small intestine
Adults
________ formation represent a _______ for the parasite
hydatid cyst’s
dead end
Hydatid cyst infection
If these intermediate animals are consumed, infection may occur.
After consumption, cyst wall disintegrates and protoscolices are freed
Protos. attach to SI and develop into adults
3 types of Hydatid cysts
Cystic
Osseous
Alveolar
Cystic
aka unilocular
Caused by E. granulosus
Osseous
Caused by E. granulosus
Alveolar
Caused by E. multilocularis
The _______ is the most common and least harmful, and the _______ is most pathogenic
unilocular cyst
alveolar cyst
3 layers of matured unilocular cyst:
(1) Pericyst
(2) Ectocyst
(3) Endocyst
Pericyst
Outermost layer (“host origin”) containing connective tissue and fibers
Ectocyst
outer, thick-layered, non-cellular wall which produces the protoscolices
Endocyst
inner thin layer
pedicel
stalk that attaches brood capsules to cyst wall
Brood capsules
are small sacks with in the cyst with numerous protoscolices
Osseous cysts are _______ but are common in the ________________
Rare
Ribs, vertebrae, and bones
Effect of Osseous cyst
Sometimes spongy bones are destroyed and collapse without warning
Alveolar cysts are found most commonly in ______ and causes ___________
the liver
Alveolar Liver Echinococcosis
In Alveolar liver Echinococcus symptoms:
jaundice and portal hypertension
sylvatic echinococcosis
Involves carnivore-herbivore relationship
Ample opportunities exist for human infection in situations in which:
domestic herbivores are raised with dogs
Dogs are infected when:
they feed on an infected butchered animal
Herbivores are infected when:
they eat herbage contaminated with dog feces
Humans are infected via:
intimate contact with dogs by accidently ingesting Echinococcus eggs
Human hydatidosis is _______
zoonotic
Echinococcus infection is common in:
NZ, AU because of sheep-dog relationship
_____ traditions further propagate Echinococcus by:
Kenyan
Consuming under cooked roasted dog intestine
Using nursing dogs- clean up feces and vomit by licking both areas
Lack of burial of the dead
Infection in _______, where _____ are used as an ingredient of the tanning solution
tanners in Lebanon
dog feces
It can take up to ______ for HD symptoms to develop
20 years
General symptoms of HD
slowly increasing pressure in the area of the cyst, resembling a slowly developing tumor
Cysts in the lungs can cause:
Coughing up of blood, difficulty in breathing (dyspnea) and chest pain
Cysts in the brain or spinal cord:
Provoke acute inflammatory response, usually in the white matter
Once the cysts rupture:
Protoscolices become free, enter circulation & travel to tissues where they produce secondary Echinococcosis
If Hydatid cyst bursts:
anaphylactic shock can occur via host immune response to proteinaceous fluid
Dx HD:
Calcified hydatid cysts revealed by XR
Hollow cysts revealed by CT
Hooks of protoscolices may be found in the sputum
Immunological tests
Teatment of HD
Surgical removal of cysts with MUCH caution to not burst the cyst open
Mebendazole/albendazole after surgery
Prevention HD
contact between dogs and intermediate hosts reduced
Personal hygiene regarding interaction with dogs
Control HD
Regular treatment of dogs with praziquantel
Sanitary disposal of waste of slaughtered animals
Public education