Exam 3 - Visceral fluke - Fasciola hepatica Flashcards
Genera that live in liver
Fasciola, Clonorchis, and Opisthorchis
Genera that live in SI
Fasciolopsis, Heterophyes, Metagonimus, and Echinostoma
Genera that live in lungs
Paragonimus
best studied trematode because of its large size
Fasciola
Fasciola is a common parasite of:
sheep and cattle, rarely found in humans
Adult fasciola reside in the:
gall bladder and bile ducts in the liver
cephalic cone
cone-shaped projection at the anterior end of fasciola
Eggs pass out of the ___ into the _____ & expelled with _______
liver
intestine
the feces
If the eggs reach water after being passed form feces:
unembryonated eggs complete their development into miracidium and hatch in 9-10 days in warmer weather
After hatching, the miracidium has about ___ in which to find a suitable _____ for further development; if not, _____
24 hr
snail host
they die
Upon penetrating a snail, miracidium metamorphoses into:
a sporocyst that gives rise to mother rediae which may give rise to daughter rediae
_____ in the brood chambers of the redia develop into _______
Germ balls
cercaria
____ emerge from the snail ____ after infection
Cercaria
5-7 wk
______ attaches to any _______ object, ______ and encyst as ______ on plants upon which sheep and cattle feed
Cercaria
aquatic
drop its tail
metacercaria
Humans become infected by eating:
contaminated plants, esp. salads
Juveniles excyst in the _____, penetrate the ______, and travel to _____ where they feed and attain ______________
duodenum
intestinal wall
liver
sexual maturity
What are responsible for the pathology associated with fascioliasis
Migration of young worms to host liver and presence of worms in the bile ducts
As larvae migrate to the bile ducts:
they cause traumatic damage as well as intense eosinophilic inflammation to the hepatic tissue
In the bile ducts, the larvae cause ______ of the biliary epithelium, and ______ of the biliary wall ducts.
hyperplasia
hardening
Acute fascioliasis
often seen in sheep
Due to ingestion of more than 10,000 metacercariae at once
Symptoms in humans
head/backache, nausea, coughing, vomiting, fever, abdominal pain, obstructive jaundice
Life span of adult flukes in humans may be:
5 to 10 years
Diagnostoc tools:
Eggs in feces
Treatment:
bithionol and praziquantel for 2 weeks
Human infection occurs ______ but is confined to _______ regions
World wide
Sheep/cattle-raising
Control/prevention
sheep & cattle feces should not be allowed near aquatic regions. Snail population should also be carefully monitored
Oral sucker vs ventral sucker
Similar in size