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PHRM 864 Therapeutics > Final Exam Random Things to Know > Flashcards

Final Exam Random Things to Know Flashcards

1
Q

MIVF fluids per day range

A

30-40 mL/kg/day

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2
Q

protein per day range if NOT in ICU

A

1-1.5 g/kg/day

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3
Q

protein per day range if pt is in the ICU/surgery

A

1.5-2 g/kg/day

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4
Q

one gram protein = ___ kcal

A

4

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5
Q

kcal per day range for surgery/ICU pt

A

25-30 kcal/kg/day

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6
Q

IBW male equation

A

50 kg + (2.3 * inches over 60”)

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7
Q

IBW female equation

A

45.5 kg + (2.3 * inches over 60”)

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8
Q

nutritional body weight formula

A

NBW = IBW + 0.25(wt - IBW)

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9
Q

CRP is used to assess accuracy of ________

A

prealbumin

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10
Q

prealbumin decreases as CRP increases -> _______

a. inflammation
b. malnutrition

A

a. inflammation

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11
Q

prealbumin decreases as CRP normal -> _______

a. inflammation
b. malnutrition

A

b. malnutrition

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12
Q

nitrogen balance formula

A

(N in) - (N out)

N in = 24-hr protein intake/6.25
N out = UUN + 4

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13
Q

REE = 1950; RQ 0.74
calculate TEE

A

1950 * 1.2 = 2340 kcal/day

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14
Q

standard distribution on non-protein calories

A

70/30 (70% carbs, 30% fat)

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15
Q

3 central venous catheter insertion sites

A

subclavian (SC)
internal jugular (IJ)
femoral

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16
Q

one gram dextrose = ____ kcal

A

3.4

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17
Q

one gram lipids = ____ kcal

A

~10

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18
Q

SMOF lipid components

A

-soybean oil 30%
-medium-chained TGs 30%
-olive oil 25%
-fish oil 15% (allergies)

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19
Q

intralipid 10% components

A

soybean oil 10%
glycerin 2.25% (allergies)
egg yolk phospholipid 1.2% (allergies)
water for injection

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20
Q

which is avoided if you have an egg allergy?

a. intralipid
b. SMOFlipid

A

a. intralipid

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21
Q

which should be avoided with a fish allergy?

a. intralipid
b. SMOFlipid

A

b. SMOFlipid

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22
Q

___ micron filter can be used for all total nutrient admixtures (TNAs) or 3-in-1 (w/lipids)

a. 0.22
b. 1.2
c. 2.0

A

b. 1.2

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23
Q

___ micron filter is only used for 2-in-1 formulations (no lipids)

a. 0.22
b. 1.2
c. 2.0

A

a. 0.22

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24
Q

CrCl < 50

a. Clinimix no electrolytes
b. Clinimix with electrolytes

A

a. Clinimix no electrolytes

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25
Q

CrCl > 50

a. Clinimix no electrolytes
b. Clinimix with electrolytes

A

b. Clinimix with electrolytes

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26
Q

trace element adjustments in liver dysfunction (2 things)

A

-d/c trace elements
-supplement individually zinc 5 mg (1 mL), selenium 60 mcg (1 mL)

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27
Q

Which of the following is TRUE about trace element adjustments in renal disease?

a. consider checking serum levels if use expected beyond 7 days
b. use selenium and chromium with caution
c. same rules apply for CRRT

A

b. use selenium and chromium with caution

28
Q

T or F: iron is recommended to be added to PNs

A

F

29
Q

TPN calcium and magnesium starting levels if normal

A

Ca 10 mEq/day
Mg 8 mEq/day

30
Q

3 main electrolyte issues in refeeding syndrome

A

hypophosphatemia
hypomagnesemia
hypokalemia

31
Q

prevention of refeeding syndrome:
-limit carbs to ___-___ gm
-limit fluids to ___ mL/day
-provide adequate amounts of ________
-provide approx ___% of total caloric needs

A

100-150
800
electrolytes
50%

32
Q

PEG location of the distal end of feeding tube

A

stomach

33
Q

PEJ location of distal end of feeding tube

A

small intestine (jejunum)

34
Q

T or F: it is ok to crush sustained-release or enteric coated formulations via enteral feeding tubes

A

F (can crush other tablets tho)

35
Q

Hodgkin’s Lymphoma is characterized by which cells?

A

Reed-Sternberg cells

36
Q

what are the 3 B symptoms?

A

fever > 38 C
drenching night sweats
weight loss greater than 10% in 6 months

37
Q

which of the following describes Hodgkin Lymphoma?

a. more frequent involvement of multiple peripheral nodes
b. noncontiguous spread
c. waldeyer ring and mesenteric nodes rarely involved
d. extranodal presentation common

A

c. waldeyer ring and mesenteric nodes rarely involved

38
Q

Hodgkin’s lymphoma 2 chemo regimens

A

ABVD
AAVD

39
Q

which one drug is different between the ABVD and AAVD regimen for HL?

A

ABVD has bleomycin, AAVD has brentuximab vedotin

40
Q

maintenance tx for relapsed HL

A

brentuximab vedotin

41
Q

tx for relapsed HL

A

high dose chemo with autologous stem cell transplant

42
Q

T or F: follicular lymphoma can transform into an aggressive NHL (non-Hodgkin lymphoma)

A

T

43
Q

NHL chemo regimen

A

R-CHOP

44
Q

what drugs are in R-CHOP?

A

-rituximab
-cyclophosphamide
-doxorubicin
-vincristine
-prednisone

45
Q

which virus can be reactivated in pts with NHL and rituximab?

A

Hep B

46
Q

two third line BiTEs for NHL

A

epcoritamab
glofitamab

47
Q

BiTEs 2 unique toxicities

A

-cytokine release syndrome (CRS)
-immune effector cell-associated neurotoxicity syndrome (ICANS)

48
Q

Multiple Myeloma CRAB criteria

A

-hypercalcemia (Ca > 11.5)
-renal dysfunction (SCr > 2 or CrCl < 40)
-anemia (Hgb < 10 or 2 below normal)
-bone lesions (one or more lesions or fractures)

49
Q

which drug class is indicated for all pts receiving primary myeloma therapy?

A

bisphosphonates

50
Q

multiple myeloma: there is an inc risk of infection with what 2 drug classes?

A

proteasome inhibitor
monoclonal antibodies

51
Q

cornerstone of Multiple Myeloma therapy

A

autologous stem cell rescue

52
Q

first line drug class for tx of CML

A

TKI inhibitors (imatinib)

53
Q

3 2nd gen TKIs

A

dasatinib
nilotinib
bosutinib

54
Q

for TKI discontinuation, which value is a deep molecular response?

a. BCR-ABL < 0.01
b. BCR-ABL < 0.05
c. BCR-ABL < 0.10
d. BCR-ABL < 0.5

A

a. BCR-ABL < 0.01

55
Q

CLL: transient lymphocytosis may occur with which inhibitors?

A

BTK inhibitors

56
Q

first line tx for CLL

A

BTK inhibitor +/- venetoclax

57
Q

which drug is NOT used 2nd line for FLT3 mutations in pts with AML?

a. imatinib
b. midostaurin
c. quizartinib
d. gilteritinib

A

a. imatinib

58
Q

the 7+3 intensive chemo regimen is for which disease state?

a. CML
b. CLL
c. AML
d. ALL

A

c. AML

59
Q

what is the 7+3 regimen for AML?

A

7 days cytarabine, 3 days of anthracycline

60
Q

important mutation for AML

A

t(15;17) = PML:RARA

61
Q

two drugs to treat APL

A

ATRA (all trans retinoic acid)
ATO (arsenic trioxide)

62
Q

SE of all trans retinoic acid (ATRA)

a. QT prolongation
b. diarrhea
c. differentiation syndrome
d. neurotoxicity

A

c. differentiation syndrome

63
Q

SE of arsenic trioxide (ATO)

a. QT prolongation
b. diarrhea
c. differentiation syndrome
d. neurotoxicity

A

a. QT prolongation

64
Q

main chemo regimen for ALL

a. CRAB
b. HyperCVAD
c. R-CHOP
d. AAVD

A

b. HyperCVAD

65
Q

what is the importance of pegaspargase in ALL?

A

pegaspargase breaks down asparagine, which cancer cells cannot make their own, so will undergo cellular death

66
Q

for ALL, if a pt is Philadelphia Chromosome positive, what drug class can we add?

A

tyrosine kinase inhibitor

PHRM 864 Therapeutics (28 decks)

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