Exam 2 - Ovarian Cancer Weddle Flashcards

1
Q

goal for initial tx for OC

a. cure
b. palliative

A

a. cure

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2
Q

current standard of therapy adjuvant chemo for OC

A

carboplatin + paclitaxel every 3 weeks

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3
Q

what is the Calvert equation for carboplatin dosing?

A

dose = AUC * (GFR + 25)

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4
Q

drug allergic rxn

a. sx persist after stopping infusion
b. sx resolve quickly after stopping infusion

A

a. sx persist after stopping infusion

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5
Q

infusion related rxns

a. sx persist after stopping infusion
b. sx resolve quickly after stopping infusion

A

b. sx resolve quickly after stopping infusion

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6
Q

which drug often causes infusion related rxns due to cremophor EL?

a. carboplatin
b. paclitaxel
c. cisplatin
d. etoposide

A

b. paclitaxel

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7
Q

premedicate paclitaxel 30 minutes prior with what 3 drugs/classes?

A

dexamethasone, benadryl, famotidine

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8
Q

if OC pt has a BRCA mutation, what drug class should be used?

A

PARP inhibitors

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9
Q

most common adverse effect of PARP inhibitors

a. neutropenia
b. anemia
c. fatigue
d. vomiting

A

b. anemia

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10
Q

if “platinum sensitive”, what regimen should be used?

A

initial chemo regimen again (carboplatin + paclitaxel)

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11
Q

if “platinum resistant”, what salvage agents can be used? (there are a lot)

A

cyclophosphamide, docetaxel, gemcitabine, …

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12
Q

T or F: there is no effective screening tool for OC

A

T

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13
Q

What would be the 1st line chemotherapy regimen of choice for someone with stage III ovarian cancer?

A

carboplatin + paclitaxel

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14
Q

What would be the 1st choice for treatment for recurrent, ovarian cancer? What do you need to ask yourself to determine therapy?

A

when did cancer re-occur? if > 6 months can reuse same regimen, if < 6 months do salvage regimen

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15
Q

two maintenance therapy options for ovarian cancer

A

-PARP inhibitors (3 of them ORN)
-bevacizumab (angiogenesis inhibitor)

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16
Q

pt relapses > 6 months following completion of initial platinum containing regimen

a. platinum sensitive
b. platinum resistant
c. platinum progressive

A

a. platinum sensitive

17
Q

pt relapses < 6 months after receiving a platinum containing regimen

a. platinum sensitive
b. platinum resistant
c. platinum progressive

A

b. platinum resistant

18
Q

No response or progression of disease during primary therapy with paclitaxel/carboplatin

a. platinum sensitive
b. platinum resistant
c. platinum progressive

A

c. platinum progressive (aka platinum refractory)

19
Q

optimally debulked

a. < 1 cm of disease
b. > 1 cm of disease

A

a. < 1 cm of disease

20
Q

sub-optimally debulked

a. < 1 cm of disease
b. > 1 cm of disease

A

b. > 1 cm of disease

21
Q

from which stage of ovarian cancer and beyond can we use carboplatin and paclitaxel?

A

stage IC

(1A and 1B only need observation and follow up in 3 months)

22
Q

“incessant ovulation” theory

A

the more ovulation cycles a woman has means the more likely they are to have cancer due to constant repairing of epithelial lining of the ovaries