Exam 2 - Ovarian Cancer Weddle Flashcards
goal for initial tx for OC
a. cure
b. palliative
a. cure
current standard of therapy adjuvant chemo for OC
carboplatin + paclitaxel every 3 weeks
what is the Calvert equation for carboplatin dosing?
dose = AUC * (GFR + 25)
drug allergic rxn
a. sx persist after stopping infusion
b. sx resolve quickly after stopping infusion
a. sx persist after stopping infusion
infusion related rxns
a. sx persist after stopping infusion
b. sx resolve quickly after stopping infusion
b. sx resolve quickly after stopping infusion
which drug often causes infusion related rxns due to cremophor EL?
a. carboplatin
b. paclitaxel
c. cisplatin
d. etoposide
b. paclitaxel
premedicate paclitaxel 30 minutes prior with what 3 drugs/classes?
dexamethasone, benadryl, famotidine
if OC pt has a BRCA mutation, what drug class should be used?
PARP inhibitors
most common adverse effect of PARP inhibitors
a. neutropenia
b. anemia
c. fatigue
d. vomiting
b. anemia
if “platinum sensitive”, what regimen should be used?
initial chemo regimen again (carboplatin + paclitaxel)
if “platinum resistant”, what salvage agents can be used? (there are a lot)
cyclophosphamide, docetaxel, gemcitabine, …
T or F: there is no effective screening tool for OC
T
What would be the 1st line chemotherapy regimen of choice for someone with stage III ovarian cancer?
carboplatin + paclitaxel
What would be the 1st choice for treatment for recurrent, ovarian cancer? What do you need to ask yourself to determine therapy?
when did cancer re-occur? if > 6 months can reuse same regimen, if < 6 months do salvage regimen
two maintenance therapy options for ovarian cancer
-PARP inhibitors (3 of them ORN)
-bevacizumab (angiogenesis inhibitor)