Exam 2 - Colorectal Cancer Weddle (not done) Flashcards
colorectal cancer is the ____ leading cancer in incidence and death in men and women
3rd
what is familial adenomatous polyposis (FAP)?
disorder where there is mutation of adenomatous polyposis coli (APC) located on chromosome 5; it is a risk factor for colorectal cancer
> ___ % of colorectal cancers are adenocarcinomas
> 95%
additional testing for CRC: we can test for __________ __________ or test for loss of genes involved in DNA mismatch repair
microsatellite instability (MSI)
dMMR or MSI-H tumor predicts a __________ benefit from adjuvant 5-FU based therapy for stage ___ disease
a. decreased; stage III
b. decreased; stage II
c. increased; stage III
d. increased; stage II
b. decreased; stage II
stage ___ CRC pts with dMMR or MSI-H disease _____ _____ from adjuvant 5-FU
a. III; can benefit
b. III; can’t benefit
c. IV; can benefit
d. IV; can’t benefit
a. III; can benefit
T or F: all pts with a colon cancer diagnosis should be tested for mismatch repair or microsatellite instability
T
is radiation therapy used mainly for colon or rectal cancer?
rectal
localized therapy for stage I and II CRC
-surgery alone (partial or total colectomy + lymph nodes)
-stage II high risk can consider chemo
T or F: stage II CRC with MSI-H or dMMR will benefit from chemotherapy
F
what drugs are in FOLFOX? (3)
5-FU
leucovorin
oxaliplatin
what drugs are in CapeOX? (2)
capecitabine
oxaliplatin
is chemotherapy indicated for stage III CRC?
yes
T or F: FOLFOX is indicated in average risk stage II CRC pts
F (for intermediate/high risk stage II)
T or F: bevacizumab, cetuximab, panitumumab, and irinotecan play a role in chemotherapy for stage III disease
F
stage III colon cancer: what are the two regimens for “low risk” pts from the IDEA trial?
a. CapeOx for 3 months
b. FOLFOX for 3-6 months
c. CapeOx for 3-6 months
d. FOLFOX for 6 months
a. CapeOx for 3 months
b. FOLFOX for 3-6 months
stage III colon cancer: what are the two regimens for “high risk” pts from the IDEA trial?
a. CapeOx for 3 months
b. FOLFOX for 3-6 months
c. CapeOx for 3-6 months
d. FOLFOX for 6 months
c. CapeOx for 3-6 months
d. FOLFOX for 6 months
which of the following is FALSE about FOLFOX?
a. requires port
b. 2-day pump
c. increased hand foot syndrome and diarrhea
d. more infusions overall
c. increased hand foot syndrome and diarrhea
(this is CapeOx)
which of the following is TRUE about CapeOx?
a. requires port
b. 2-day pump
c. increased myelosuppression and mouth sores
d. less infusions overall
d. less infusions overall
which regimen increases myelosuppression and mouth sores?
a. FOLFOX
b. CapeOx
a. FOLFOX
which regimen increases risk of hand foot syndrome and diarrhea?
a. FOLFOX
b. CapeOx
b. CapeOx
which regimen requires an infusion pump that you take home?
a. FOLFOX
b. CapeOx
a. FOLFOX
T or F: pembrolizumab and nivolumab have shown benefit in the metastatic colon cancer setting
T
T or F: KRAS mutations predict lack of response to anti-EGFR mAbs
T
if someone received FOLFOX chemotherapy, what would be the 2nd line tx option if they progress?
FOLFIRI
which pts is FOLFIRINOX usually for?
young, robust pts
FOLFIRINOX drugs (4)
5-FU
leucovorin
irinotecan
oxaliplatin
