Additional Agents Dykhuizen

Question 1

Which of the following drugs acts by binding to HER2? (review)

a. Trastuzumab
b. Pertuzumab
c. Margetuximab
d. All of the above

Answer 1

d. All of the above

Question 2

Which of the following drugs exerts antitumor effects by inhibiting the interaction between PD1 and PDL1? (review)

a. Cetuximab
b. Ipilimumab
c. Atezolizumab
d. All of the above

Answer 2

c. Atezolizumab

Question 3

What concept of immunity must be overcome for the immune system to successfully eliminate cancer cells? (review)

a. Antibody-dependent cellular cytotoxicity
b. Central tolerance
c. T-cell activity
d. B-cell activity

Answer 3

b. Central tolerance

Question 4

What is the function of the cetuximab? (review)

a. To block EGFR ligand binding
b. The same as panitumumab
c. To binding VEGF
d. The same at Pertuzumab
e. A and B

Answer 4

e. A and B

Question 5

SW is a 66 yo postmenopausal woman with newly diagnosed metastatic BC to the lung (ER/PR positive; HER2-negative). This was found on a chest X-ray and was confirmed by CT scan and biopsy. She is otherwise asymptomatic from her cancer and feels well. Which of the following regimens would be best to treat her cancer at this time? (review)

a. Letrozole plus palbociclib
b. Lapatinib plus capecitabine
c. Trastuzumab
d. Paclitaxel
e. Irinotecan

Answer 5

a. Letrozole plus palbociclib

Question 6

2 DNA methylation inhibitors (slide 12)

Answer 6

-azacitidine
-decitabine

Question 7

T or F: acetylation of histones can decrease the transcription of tumor suppressor genes

Answer 7

F (increase)

Question 8

azacitibine and decitabine indication

Answer 8

tx of pts with myelodysplastic syndrome (MDS)

Question 9

Multiple myeloma is a ___-cell cancer

Answer 9

B

Question 10

drug that is inhibitor of proteasome activity

Answer 10

bortezomib (“-zomibs”)

Question 11

thalidomide binds to a ubiquitin ligase protein called _______ and increases protein degradation of new substrates

a. acrolein
b. celebrex
c. cereblon

Answer 11

c. cereblon

Question 12

thalidomide leads to degradation of which transcription factor that is important for limb development?

Answer 12

SALL4

Question 13

Pomalidomide is approved for tx of what two cancers?

Answer 13

-multiple myeloma
-Kaposi sarcoma

Question 14

T or F: pomalidomide is regulated by REMS

Answer 14

T

Question 15

what drug is a BCL-2 inhibitor that drives cell death via apoptosis?

a. vortioxetine
b. venetoclax
c. thalidomide
d. pomalidomide

Answer 15

b. venetoclax

Question 16

T or F: BCL-2 is an apoptotic protein

Answer 16

F (anti-apoptotic; so we want to inhibit this)

Question 17

venetoclax was approved in 2020 in combo with __________ for AML

a. bortezomib
b. azacitidine
c. decitabine
d. thalidomide

Answer 17

b. azacitidine

Question 18

1st FDA approved small molecule that inhibits a protein-protein interaction

a. bortezomib
b. azacitidine
c. decitabine
d. thalidomide
e. venetoclax

Answer 18

e. venetoclax