Final Exam - IBS Flashcards
1
Q
4 different types of IBS
A
IBS-U (undefined)
IBS-M (mixed)
IBS-C (constipation predominant)
IBS-D (diarrhea predominant)
2
Q
last line of therapy for IBS-C
A
SSRIs
3
Q
SSRIs MOA for IBS-C
A
reduce visceral sensitivity
4
Q
tegaserod MOA
A
5-HT4 agonist (stimulates peristalsis and GI secretions)
5
Q
first step for IBS-D
A
dietary modifications
6
Q
2nd step for IBS-D
A
add loperamide or anti-spasmodic agent (dicyclomine)
7
Q
eluxadoline brand name
A
viberzi
(opioid receptor antagonist)
8
Q
antidepressants (TCA) are most beneficial in patients with ?
A
IBS-D
9
Q
max daily dose for Lomotil
A
20 mg
10
Q
true or false: alosetron (Lotronex) is a 5-HT4 receptor antagonist
A
false (it is a 5-HT3 receptor antagonist)
11
Q
rifaximin MOA for IBS-D
A
poorly absorbed non-systemic broad-spectrum antibiotic that targets the gut
