Final Exam: Disorders of the Thyroid Gland (Unit 11) Flashcards
The Thyroid produces what 3 hormones ?
- Thyroxine (T4)
- Triiodothyrone (T3)
- Calcitonin
90% of hormone secreted by the Thyroid is what ?
Thyroxine (T4)
Which Thyroid hormone is more potent, T3 or T4 ?
T3
The Thyroid gland works in what type of feedback loop ?
Negative
When circulating levels of thyroid hormone are low, _______ (_________ _______________ __________) is released by the hypothalamus ?
TRH (Thyrotropin releasing hormone)
When TRH is released by the hypothalamus, it causes what ?
causes TSH (thyroid stimulating hormone) to be released by the anterior pituitary gland)
TSH stimulates the production and release of what ?
T3 and T4 in the thyroid
Where is TSH produced ?
Anterior pituitary gland
Thyroid cells are stimulated to grow, which may result in what ?
Overactive (hyperthyroidism) or Underactive (hypothyroidism) thyroid
The most common cause of Thyroid issues worldwide is what ?
Lack of iodine in the diet
In the US what is the most common cause of thyroid issues ?
Over or under production of thyroid hormones or nodules that develop
What is a Goiter ?
Enlargement of the Thyroid
_____ & ____ levels are measured to determine whether a goiter is associated with hyperthyroidism, hypothyroidism, or normal thyroid function ?
TSH & T4
Thyroid __________ are measured to assess for thyroiditis (inflammation of the thyroid) ?
Antibodies
What is the Tx for Goiters to prevent further enlargement ?
Tx with thyroid hormones
What is the Tx for large Goiters ?
Surgery
What is Levothyroxine ?
Synthetic thyroid hormone
Thyroid nodules may be _______ (95%) or __________ ?
Benign (95%) or Malignant
Most thyroid cancers are what ?
Treatable
What is a Sign of Thyroid Cancer ?
Presences of painless, palpable nodule(s) in an enlarged thyroid gland
Thyroid cancer can metastasize to what ?
cervical nodes, and obstruct trachea
What are s/s of an enlarged thyroid gland ?
- Changes in voice (increased Hoarseness)
- Difficulty swallowing
What is the best diagnostic test to test for Malignant Thyroid cancer ?
Ultrasound-guided fine-needle aspiration
What is the Tx for Thyroid nodules and cancer ?
- Radiation
- Partial or total thyroidectomy
What Is Thyroiditis ?
Inflammation of the thyroid gland
Acute thyroiditis is due to what type of infections ?
Bacterial or Fungal infections
Subacute granulomatous thyroiditis is thought to be cause by what type of infection ?
Viral infection
What is another name for Chronic autoimmune thyroiditis ?
Hashimoto’s thyroiditis
What is Hashimoto’s thyroiditis ?
Thyroid tissue is replaced by lymphocytes and fibrous (scar) tissue
Recovery from thyroiditis (viral, bacterial, fungal) usually occurs when ?
within weeks to months
Acute thyroiditis caused by bacteria can be treated how ?
with Antibiotics
How can subacute thyroiditis (viral) be treated ?
NSAIDS
Myxedema coma falls under what type thyroid dysfunction ?
Hypothyroidism
Thyroid storm falls under what thyroid dysfunction ?
Hyperthyroidism
________________: A sustained increase in synthesis and release of thyroid hormones by the thyroid gland ?
Hyperthyroidism
Hyperthyroidism occurs most frequently in who ?
Women
highest frequency in 20 to 40 year olds
What is the most common form of Hyperthyroidism ?
Grave’s disease
What are other causes of Hyperthyroidism ?
- Thyroiditis
- Toxic nodular goiter
- Exogenous iodine excess
- pituitary tumors
- Thyroid cancer
What is another name for Thyrotoxicosis ?
Thyroid storm
What does Thyrotoxicosis (AKA: thyroid storm) result from ?
excess circulating levels of T3, T4, or both
_______________ and ________________ occur together in Grave’s disease ?
Hyperthyroidism and thyrotoxicosis
Grave’s disease is characterized by what ?
- Diffuse thyroid enlargement
- Excessive thyroid hormone secretion
Grave’s disease accounts for ____% of cases of hyperthyroidism ?
75%
Graves disease may progress to what ?
Destruction of thyroid tissue, causing hypothyroidism
What is the patho/etiology of Graves disease ?
Overproduction of T3 and T4
What are the clinical manifestations of Graves’ disease/Hyperthyroidism ?
- Increased metabolism
- Increased tissue sensitivity to stimulation by sympathetic nervous system
- Abnormal eye appearance or function
- Exophthalmos
What is Exophthalmos ?
Protrusion of eyeballs from the orbits
Cardiovascular manifestations such as…
- Bruit over thyroid gland
- Systolic hypertension
- increased cardiac output
- Dysrhythmias
are seen with what type of Thyroid dysfunction ?
Graves’ disease (Hyperthyroidism)
GI manifestations such as…
- increased appetite
- thirst
- weight loss
- diarrhea
- Hepatosplenomegaly
are seen with what type of Thyroid dysfunction ?
Graves’ disease (hyperthyroidism)