Exam 3 - CAD, Inflammatory and Structural Heart Disorders, & Vascular Disorders Flashcards
What is the most common type of CVD ?
CAD
Coronary Artery Disease is also known as what ?
Athersclerosis
What is Athersclerosis ?
Hardening of the arteries
Athersclerosis can occur in any _________ in the body ?
artery
CAD can be what ?
- Asymptomatic
- Stable angina
- Unstable angina and MI (Acute Coronary Syndrome)
What is the Earliest stage of CAD/Athersclerosis ?
Fatty streaks
Earliest lesions, potentially reversible
What is the 2nd stage of CAD/Athersclerosis ?
Fibrous plaque
(The fatty streak is covered by collagen, forming a fibrous plaque that appears grayish or whitish.
Results = Narrowing of the vessel lumen)
What stage of CAD/Atherosclerosis is defined as: Continued inflammation which can result in plaque instability, ulceration, and rupture ?
Complicated Lesion (3rd stage)
What is the term for when The body forms new vessel connections to bypass blockages ?
Collateral circulation
When occlusion of the coronary arteries occurs slowly over a long period, the chance that adequate collateral circulation will develop is __________ ?
greater !
What are Non-modifiable risk factors for CAD ?
- Age
- Gender (> in men until age 65, then an increase in deaths of women)
- Ethnicity
- Family History
- Genetics
What are Modifiable (try to manage these risks) risk factors for CAD ?
- Elevated serum lipids
- Hypertension
- Tobacco use
- Physical inactivity
- Obesity
- Diabetes
What is the #1 side effect of the drug Niacin ?
Flushing/Reddining of the face
What is a Drug that decreases cholesterol absorption ?
Ezetimibe (Zetia)
What drugs increase Lipoprotein removal ?
Bile acid sequestrates
What are dugs that restrict lipoprotein production ?
Statins & Niacin
Whats an example of Antiplatelet therapy ?
Low dose aspirin. (decreases thrombus formation)
What type of Angina is Reversible (temporary) myocardial ischemia ?
Chronic Stable Angina
*NOT an MI, they just aren’t getting good perfusion to the heart, causing chest pain
What is Chronic Stable Angina characterized by ?
Intermittent chest pain (pressure/squeezing) that occurs over a long period with the SAME PATTERN OF ONSET, DURATION, AND INTENSITY OF SYMPTOMS
What type of Angina is usually caused by something ?
Chronic Stable Angina
What is an ST depression very indicative of ?
Ischemia being present
What are precipitating factors of Chronic Stable Angina ?
- physical activity
- strong emotions
- temperature extremes
- cigarette smoking
- sexual activity (extra physical activity)
- stimulants
- circadian rhythm pattern
What type /classifications of people may not present with the typical symptoms of angina or MI ?
Women & Older adults
In regards to angina or MI’s, women and Older adults may present with what ?
- Dyspnea
- Fatigue
- N/V
What type of Ischemia occurs in the absence of any subjective symptoms ?
Silent Ischemia
What type of ischemia is associated with diabetic neuropathy ?
Silent Ischemia
damaged nerves can’t alert to pain
How is Silent Ischemia confirmed ?
confirmed by ECG changes
Nitroglycerin should NOT be taken when a pt. is taking meds for what ?
Meds for Erectile Dysfunction
Why should you not take Nitroglycerin if you are taking meds for erectile dysfunction ?
The combination of both will Tank the BP !
Total cholesterol should be under what # ?
under 200
After cardiac cath’s what do you need to monitor for ?
signs of re-occulusion
Ex: - chest pain
- ST elevation - etc.,
in regard to cardiac catheterizations and stents being placed…there is a need for what for a few months to a year or more due to risk of restenosis ?
Need for:
- Aspirin (ASA) & Plavix
What are acute interventions for Anginal attacks ?
- Administration of supplemental oxygen
- Assess VS & PoX
- 12-lead ECG
- Auscultation of heart sounds
- Prompt relief with Sublingual Nitro
In regards to an Acute Anginal Attack, how many Nitro can you take and how far apart ?
can take a total of 3 Nitro, 5min apart
If your having an Acute anginal attack, take 1 Nitro, and have no relief of symptoms or the symptoms worsen, what is the likely cause ?
Likely Acute Coronary Syndrome
What Syndrome develops when ischemia is prolonged and is not immediately reversible ?
Acute Coronary Syndrome (ACS)
What does ACS encompass ?
- Unstable angina
- Non-ST-segment-elevation myocardial infarction (NSTEMI)
- ST-segment-elevation MI (STEMI)
What do NSTEMIs have ?
- ST elevation
& - Positive cardiac enzymes !
What type of STEMI requires prompt treatment ?
NSTEMI !
What medical condition is defined as –> An infection of the inner layer of the heart that usually affects the cardiac valves ?
Infective Endocarditis
In what kind of medical condition does Vegetation (fibrin, leukocytes, platelets, and microbes) adhere to the valve or endocardium, and can embolize into circulation ?
Infective Endocarditis
Clinical manifestations such as: - Nonspecific - fever in 90% of patients - chills - weakness - fatigue - arthralgia (joint pain) Are present with what type of medical condition ?
Infective Endocarditis
additional Vascular/Respiratory manifestations such as:
- Splinter hemorrhages in nail beds (black longitudinal streaks)
- Petechiae
- Osler’s nodes on fingers or toes (painful red lesions)
- Janeway’s lesions on palms or soles
- Roth’s spots (hemorrhagic retinal lesions)
- Murmurs in most patients
Are seen with what medical condition ?
Infective Endocarditis
What medical condition is seen in up to 80% of patients with aortic valve endocarditis ?
HF
With Infective Endocarditis, what should you screen patients for a history of ?
- Recent dental, urologic, surgical, or gynecologic procedures
- Recent cardiac catheterization or surgery
- Intravascular device placement
- Renal dialysis
- Skin, respiratory, or urinary tract infection
- History of previous Infective Endocarditis
Pt’s with a history of Infective Endocarditis are more at risk for what ?
Re-occurence
Patients with Infective Endocarditis may need what in terms of collaborative care ?
May need open-heart surgery to replace the valve all together
In terms of Collaborative Care for Infective Endocarditis, Prophylactic antibiotic treatment may be needed for patients having what ?
- Certain dental procedures (especially if the pt has a replacement heart valve or valve disease)
- Respiratory tract incisions
- GI wound infections
- Congenital heart disease or heart transplant
What type of treatment is there for Infective Endocarditis ?
Antibiotics many times IV
Sometimes for 4-6 weeks
(Intensive treatment plan !)
What is Acute Pericarditis ?
Inflammation of the pericardial sac (pericardium)
Acute Pericarditis results from what ?
- Virus (coxsackie B virus)
- Bacteria
- Trauma
- Radiation therapy
- MI
etc. ,
What is the most common Virus that causes Acute Pericarditis ?
Coxsackie B virus
What are clinical manifestations of Acute Pericarditis ?
- Severe sharp chest pain
- pleuritic chest pain (worse with inspiration) and when lying down
- Relieved by sitting up and leaning forward
- Pericardial friction rub (heard best at the L sternal boarder w/ pt. leaning forward)
What relieves Acute Pericarditis ?
Relieved by sitting up and leaning forward
What does Pericardial friction rub sound like ?
Scratching/grating high pitched sound
What are complications of Acute Pericarditis ?
- Pericardial effusion
- Cardiac Tamponade
What are types of Diagnostic studies used for Acute Pericarditis ?
- ECG (to rule out MI)
- Echo
- WBC
- CRP
- May have elevated troponin
When treating Acute Pericarditis, what medication(s) will give the best pain relief ?
**NSAIDS
What are s/s of Cardiac Tamponade ?
- Muffled heart sounds
- Tachypnea
- Tachycardia
- May need pericardiocentesis
Rheumatic Fever and Rheumatic Heart Disease are complications from what ?
Group A streptococcal pharyngitis
Type III Hypersensitivity
What are clinical manifestations of Rheumatic Fever and Rheumatic Heart Disease ?
- Carditis
- Arthritis
- Sydenhams’s chorea (involuntary movements)
- Erythema marginatum (red lesions on skin. On the trunk of the pt’s body or limbs)
What is the Tx for Rheumatic Fever and Rheumatic Heart Disease ?
- Antibiotics to prevent spread
- Anti-inflammatories
What happens if Rheumatic Fever (or strep throat) isn’t taken care of right away ?
Leads to Rheumatic Heart Disease (which is a life long disease)
__________ is where the Valve orifice is restricted ?
Stenosis
With _________ forward blood flow is impeded ?
Stenosis
______________ results in the incomplete closure of valve leaflets ?
Regurgitation
_____________ results in the backward flow of blood ?
Regurgitation
S1 is the closure of the __________ and ___________ valves ?
Tricuspid and Mitral valves
Which one, S1 or S2 is the beginning of systole ?
S1
S2 is the closure of the __________ and __________ valves ?
aortic and pulmonic valves
True or False: Mitral Valve Prolapse has an unknown cause ?
True
If a pt. has a Hx of a murmur(s) and is reporting new onset chest pain, dizziness, SOB, etc., what is the likely cause ?
Pt. may not have enough cardiac output. –> Could lead to an MI, Stroke, etc., so notify the MD !
Porcine valves are also known as what ?
Biologic valves