Final Exam - Diabetes (Unit 10) Flashcards
Diabetes focuses on what type of cells in the pancreas ?
Beta cells
What does the Endocrine system deal with in general ?
Hormones
What is the Endocrine system comprised of ?
Comprised of organs referred to as glands
What does the Endocrine system produce ?
Hormones that are secreted into the blood to affect specific target tissues
What does Erythropoietin do ?
Stimulates RBC production/growth
What organ secrets Erythropoietin ?
Kidneys
What are 2 examples of a Simple Feedback Loop ?
- Negative feedback
- Positive Feedback
__________ Feedback - reverses the change in the blood level ?
Negative Feedback
What is an example of Negative Feedback ?
Insulin and Glucose
_________ Feedback - Increases the target organ action beyond normal ?
Positive Feedback
What is an example of Positive Feedback ?
Pressure receptors in the vagina stimulate oxytocin release, which increases contractions. (Ex: of Labor)
- were exacerbating the issue going on! we want to see the contractions increase!
The Simple Feedback Loop essentially does what ?
Mechanism that stimulates or inhibits hormone synthesis.
- It signals the body… Hey, we don’t have enough hormone… make more ! OR it might give feedback saying “we have too much”… make less !
_________ Feedback - Is communication among several glands to turn hormones on/off ?
Complex Feedback
Cortisol secretions are typically __________ in the morning and ______ at night ?
High in the morning
Low at night
In the body, if our glucose levels are getting to high, what happens ?
We secret more insulin to combat the high glucose levels
In the body, What happens if our glucose level is too low ?
Our insulin stops secreting ! Our pancreas says “hold -up, we don’t need anymore insulin right now! STOP sending insulin down!
___________ is defined as a chronic multi system disease related to
- Abnormal insulin production
- Impaired insulin utilization
- or both ?
Diabetes
What type of Diabetes does not have insulin to work with ?
Type 1
What type of Diabetes has insulin to work with, but its defective ?
Type 2
What type of Diabetes has to do with blood sugars ?
Diabetes Mellitus
Diabetes is the leading cause of what (3 things) ?
- End Stage Renal Disease (ESRD)
- Adult blindness (Retinopathy)
- Non-traumatic lower limb amputations (can result from wounds not healing properly or just poor blood flow to the extremities)
Most commonly ESRD is the result of what ? in regards to diabetes
Result of unmanaged/poorly managed diabetes
Diabetes is a Major contributing factor (2-4x higher) for what ?
- Heart disease
- Stroke
(this is b/c of the poor circulation that develops from diabetes)
Insulin is produced by what ?
Beta (B) cells, the Islets of Langerhans
Where does Insulin originate ?
the Pancreas !
Insulin is released _____________ into the bloodstream in small increments, with __________ amounts released after food
(*Negative Feedback process –> we release more insulin if we sense that there is more glucose in the bloodstream)
- Continuously
- Larger
Insulin promotes _________ transport from the bloodstream across the cell membrane to the cytoplasm of the cell ?
glucose
What is an example of Secondary Diabetes ?
Cystic Fibrosis induced Diabetes
How does insulin work in the body (what is its job after it gets released from the pancreas) ?
Once released from the pancreas……… it gets secreted into the bloodstream and grabs the glucose molecules and transports it out of the bloodstream and into the cell tissues for it to be used as energy !
What type of Diabetes was Formerly known as “juvenile-onset” or “insulin-dependent” diabetes ?
Type 1
What type of Diabetes most often occurs in people younger than 40 years of age (40% before age 20) ?
Type 1
What are 2 possible causes of Type 1 Diabetes ?
- Genetic
- Viral
what type of diabetes is considered an Autoimmune disorder ?
Type 1
Type 1 Diabetes is the progressive destruction of what ?
Progressive destruction of pancreatic (Beta) cells by the bodies own T cells
(pancreatic cells are getting destroyed by the bodies own immune system)0
When do the Manifestations of Type 1 Diabetes occur ?
They develope when the pancreas can no longer produce insulin
(autoantibodies cause a reduction of 80% to 90% in normal cell function before manifestations occur)
What is the Onset time of symptoms with Type 1 Diabetes ?
Rapid onset !
What are symptoms of Type 1 Diabetes ?
- Recent or sudden weight loss
- Weakness/fatigue
- Polydipsia (excessive thirst)
- Polyuria (excessive thirst)
- Polyphagia (Excessive hunger)
When pt’s have type 1 diabetes, there blood sugars can do what ?
Sky rocket very quickly !
- the reason there blood sugars get sooo high is b/c they have no insulin to work with
When pt’s with type 1 diabetes blood sugars sky rocket, what do they typically present to the ED with ?
Diabetic Ketoacidosis (DKA)
Type 2 Diabetes usually occurs in what age range ?
People over 35 years of age
Type 2 Diabetes is greater in some ethnic populations such as what ?
- African Americans
- Hispanic Americans
- Native Americans
- Alaskan Natives
In type 2 Diabetes the pancreas continues to do what ?
Continues to produce some endogenous insulin HOWEVER, the insulin produced is either insufficient or is poorly utilized by tissues
What type of onset is seen with Type 2 Diabetes ?
Gradual onset
In regards to Type 2 Diabetes, persons may god _______ with undetected hyperglycemia ?
years
What are the Symptoms of Type 2 Diabetes ?
- Nonspecific symptoms
- May have classic symptoms of type 1
- Fatigue
- Recurrent infection
- Recurrent vaginal yeast or monilia infection
- Prolonged wound healing (due to poor circulation)
- Visual changes
If a person has recurrent infections, what might we consider doing ?
getting a Blood Sugar to determine if Diabetes is the cause
With type 2 diabetes, pt will run into ____ & ____ vascular complications ?
Micro & Macro vascular complications
in regards to type 2 diabetes, what are examples of Macro vascular complications ?
- Cerebral vascular accidents (like stroke)
- Cardiovascular complications
(poor circulation of the cardiovascular system OR peripheral vascular disease)
In regards to type 2 diabetes, what are examples of Micro vascular complications ?
- Retinopathy (retina working overtime b/c of poor circulation)
- Neuropathy (the nerves don’t have good blood supple either, resulting in less sensation to the extremities)
- Nephropathy (kidneys are working overtime, b/c of the poor blood flow)
What are 4 methods to diagnose Diabetes ?
- Hemoglobin A1C _> 6.5
- Fasting plasma glucose level >126mg/dL (on 2 occasions )
- Random or casual plasma glucose measurement _>200mg/dL plus symptoms (DONT need to fast for this )
- 2 hr oral glucose tolerance test level _>200mg/dL when a glucose load of 75g is used
Where do we want A1C levels to be ?
as low as possible
Hemoglobin A1C levels are useful in determing what ?
Glycemic levels over time (3-4 months)
What diagnostic test for diabetes, shows the amount of glucose attached to hemoglobin molecules over RBCs life span ?
Hemoglobin A1C
True or False: Hemoglobin A1C requires regular assessments ?
True
Having a normal A1C reduces the risks of what ?
- retinopathy
- nephropathy
- neuropathy
True or False: when screening for type 2 DM, you should provide routine screening for overweight adults over the age of 45yrs ?
True
When screening for type 2 DM, what is the preferred screening method in the clinical setting for individuals > 45yrs of age ?
Fasting plasma glucose
With the 2 diabetes, what do we really want to emphasize ?
Weight Loss !
Type 2 Diabetes, is tied very directly to what ?
being overweight
What is Metabolic Syndrome defined as ?
A cluster of abnormalities that increases the risk for cardiovascular disease and diabetes
Metabolic Syndrome can be a risk factor for what ?
Diabetes
What is Metabolic Syndrome characterized by ?
Insulin resistance
Metabolic Syndrome is diagnosed by the 3 or more of the following (5 in total) ?
- Waist circumference of _> 40 inches in men or _> 35 inches in women
- Triglycerides > 150mg/dL or being treated
- HDL cholesterol <40 for men, <50 for women, or being treated
- BP _> 130mHg systolic or _> 85mmHg diastolic, or being treated
- Fasting glucose is _>100mg/dL, or being treated
What type of Diabetes is defined as the Blood glucose being high, but not high enough to be diagnosed as having diabetes ?
Prediabetes
Most people with Prediabetes are at increased risk for developing what type of diabetes ?
Type 2
if no preventative measures are taken, the condition usually will develop within 10 years
What is a Fasting Glucose range for prediabetics ?
100 - 125
What is the Hemoglobin A1C range for Prediabetics ?
5.7% - 6.4%
What is the 2 Hour plasma glucose range for Prediabetics ?
140-199mg/dL
after drinking a drink high in glucose
What is a Normal Blood Glucose ?
70 - 100
For a individual to be diagnosed with diabetes, they have to have a fasting glucose of what ?
> 126 on 2 separate occasions
Prediabetes is characterized by what ?
- Impaired Fasting Glucose (IFG)
- Impaired glucose tolerance (IGT)
If a individual is considered pre-diabetic and has a fasting blood glucose of 100 - 125, what will we Encourage ?
LIFESTYLE MODIFICATIONS !
- we DON’T skip to meds right away
With pre-diabetes, _____-______ damage is already occurring to the heart and blood vessels ?
Long-term
In regards to symptoms, pre-diabetics present how ?
usually with no symptoms
With pre-diabetics, we must watch for diabetes symptoms such as ? to see if their crossing over the threshold into diabetes ?
3 P’s
- polyuria
- polyphagia
- polydipsia
- fatigue
- frequent infections
- slow/poor wound healing
With pre-diabetics what do we want to encourage ?
- a healthy weight
- exercise
- engage in/practice carb counting
With pre-diabetics what do we want to be checking regularly ?
- Blood sugars
- A1C
Gestational Diabetes develops when ?
During pregnancy
When is Gestational Diabetes detected ?
24 to 28 weeks of gestation
When do normal glucose levels usually return with gestational diabetes ?
6 weeks post partum
With gestational diabetes, there is an increased risk of what ?
- cesarean delivery
- perinatal death
- neonata complications
Women who develop gestational diabetes, are at increased risk for developing what 5 to 10 years down the road ?
Type 2 diabetes
*we need to monitor because it can develop over time
What is first line treatment/therapy for women with gestational diabetes ?
- nutrition
- lifestyle modifications
- frequent blood sugar checks
If first line treatment for women with gestational diabetes isn’t effective, what is the next line of treatment ?
Temporary INJECTABLE insulin
True or False: A lot of the times, women with gestational diabetes or regular diabetes have very large infants, which is called Macrosomia ?
True
Secondary Diabetes results from what ?
another medical condition
What are examples of medical conditions that cause Secondary Diabetes ?
- Cushing syndrome (Hypercortisolism)
- Hyperthyroidism
- Pancreatitis
- Parenteral nutrition (TPN)
- Cystic fibrosis
What is the treatment for Secondary Diabetes ?
Treatment of the medical condition that is causing the abnormal glucose level
- Usually when the medical condition is treated, the diabetes resolves
What are goals for diabetes management ?
- Patient teaching (self monitoring of blood glucose)
- Nutritional therapy
- Drug therapy
- Exercise
- Promote well-being
- Prevent acute complications
- Delay onset and progression of long-term complications
- A lot of lifestyle modifications
Why can’t pregnant women with gestational diabetes be placed on oral anti-glycemic medications like metformin
they are considered Teratogens ! which are very harmful for fetal development !
Women with gestational diabetes need to be on what type of insulin ?
INJECTABLE insulin
What does level 1 of patient teaching for DM involve ?
Survival skills
- glucose monitoring
- insulin administration
- hypoglycemia prevention and administration
What does level 2 of patient teaching for type 2 DM involve ?
- Goals for control
- Diet management
- sick-day guidelines
True or false: its important to teach pt’s with diabetes that they must carry identification indicating there diagnosis of diabetes ?
True
True or False: When providing patient teaching for type 2 diabetes, we want to enable the patient to become the most active participant in his/her care ?
True
What type of diabetes requires insulin ?
Type 1
When is insulin required for patients with type 2 diabetes ?
Required for those who cannot control their blood glucose by other means (ex: if a pt. has made lifestyle modifications with no improvement)
What is the only type of insulin used today ?
Human insulin
True or False: insulins differ in regards to there onset, peak, action, and duration ?
True
What are the different types of insulin ?
- Rapid acting
- Short acting
- Intermediate acting
- Long acting
What types of insulin are typically given before meals ?
- Rapid acting
- Short acting
What are 3 examples of Rapid acting insulin ?
- Lispro (Humalog)
- Aspart ( NovoLog)
- Glulisine (Apidral)
What is an examples of Short acting insulin ?
- Regular insulin (Humulin R, Novolin R, ReliOn R)
What is an example of intermediate acting insulin ?
- NPH insulin (Humulin N, Novolin N, ReliOn N)
What are 2 examples of Long acting insulin ?
- Glargine (Lantus)
- Detemir (Levemir)
How many times a day is long acting insulin given ?
Once a day
Long acting insulin is given a lot of times when ?
@ night
What type of insulin is “clody insulin” ?
NPH insulin
What is the Onset time of Rapid acting insulin ?
15 min
5-15min
What is the peak time for Rapid acting insulin ?
60 - 90 min
What is the Duration of Rapid acting insulin ?
3-4 hrs
What is the onset time of short acting insulin ?
30min - 1hr
What is the peak time for Short acting insulin ?
2-3hrs
What is the Duration of Short acting insulin ?
3-6hrs
What is the Onset time of intermediate acting insulin ?
2-4hrs
What is the peak time for intermediate acting insulin ?
4-10hrs
What is the Duration for Intermediate acting insulin ?
10-16hrs
What is the Onset time for Long acting insulin ?
1-2hrs
What is the peak time for Long acting insulin ?
No pronounced peak