Final Exam Flashcards
homeostasis
maintaining a stable internal environment despite external conditions
components of feedback systems
stimulus, receptor, afferent pathway, control center, efferent pathway, effector
negative feedback
most common
keep the system near its set point
change in one direction causes a response opposite that direction
temperature, blood Ca+2 levels, BP
positive feedback system
not homeostatic
response reinforced the stimulus
requires an outside stimulus to stop the response
labor and childbirth, blood clotting
ventral body cavities
thoracic and abdominopelvic cavity
dorsal body cavity
cranial and vertebral cavity
thoracic cavity
pleural cavity
mediastinum (pericardial)
abdominopelvic cavity
abdominal and pelvic cavity
frontal plane
front and back
sagittal plane
right and left
midsagittal
symmetrical right and left
transverse plane
top and bottom
superior
toward the head
inferior
away from the head
ventral/anterior
toward the front
dorsal/posterior
toward the back
medial
toward the midline
lateral
away from the midline
proximal
close to the point of attachment
distal
further from the point of attachment
superficial
towards the body surface
deep
away from the body surface
3 elements of biomolecules
carbon, hydrogen, oxygen
4 biomolecules
carbohydrates, lipids, proteins, nucleotides
carbohydrates
most abundant
glucose C6H12O6
monosaccharides-simple sugars; 5-6 carbons
-ribose, deoxyribose, glucose, galactose, fructose
disaccharides-double sugars via dehydration synthesis
-sucrose (glucose + fructose), lactose (glucose + galactose), maltose (glucose + glucose)
polysaccharide- glycogen, starch, cellulose
fuels ATP production
cell-cell recognition
structural
lipids
non-polar and not water-soluble
triglycerides, phospholipids, steroids, eicosanoids
triglycerides
glycerol backbone with 3 fatty acid tails
saturate-contain only single covalent bonds, fats are solids at room temp
unsaturated-1+ double covalent bonds, liquids at room temp
energy storage, insulation, cushioning
phospholipids
modified triglycerides with phosphate and 2 fatty acid tails
amphipathic, heads are hydrophilic and tails are hydrophobic
create phospholipids bilayer
steroids
4-linked carbon rings cholesterol-most important stabilize cell membranes required for vitamin D synthesis steroid hormones required for the production of bile salts
eicosanoids
modified 20-carbon fatty acids
thromboxanes-blood clotting
leukotrienes-inflammation
prostaglandins-smooth muscle contractions
proteins
polymers of amino acids primary-strands secondary-alpha helix or beta-sheet tertiary-3D shape quarternary-several chains together structural-mechanical support enzymes transport, contractile, communication, defensive
enzymes
biological catalysts
speed up reactions without themselves being altered
decreases activation energy of a system
substrate (ligand) binds to the active site, catalyzes, and forms products
nucleotides
phosphate group, 5-carbon, base
ATP, ADP, cAMP, DNA, RNA
DNA
deoxyribose double-stranded A, T, C, G genetic information in the nucleus
RNA
ribose single-stranded A, U, G, C codes for protein synthesis in the nucleus and cytoplasm
diffusion
movement of molecules from an area of high concentration to an area of low concentration
does not require ATP
occurs along a concentration gradient
continues until equilibrium
takes place across a semi-permeable membrane
factors affecting diffusion
molecules lipid solubility
molecules size
lipid composition of the membrane
rate of diffusion is faster if
membrane surface area is larger membrane is thinner concentration gradient is larger the membrane is permeable to the molecule temperature is increase molecular size is smaller
osmosis
net diffusion of a solvent (water) through a selectively permeable membrane
water will move to the side with the most OAPs
-osmotically active particles-nonpenetrating solutes
-does not diffuse thru the membrane
tonicity
a measure of solutions ability to change cell shape by promoting osmosis
isotonic-same concentration of OAPs in solution and in the cell, no shape change
hypertonic-more OAPs in solution than the cell, water leaves the cell, the cell will shrink
hypotonic-less OAPs in solution than the cell, water enters the cell, the cell will swell and lyse
active transport processes
requires ATP
molecules being moved against a concentration gradient
primary active, secondary active, vesicular transport
primary active transport
sodium-potassium pump
3 Na move out and 2 K move in
secondary active transport (cotransport)
gradients created by primary pumps store energy
as particles leak back into their original position they drag other substances with them
symport-move in the same direction (Na and glucose)
antiport-opposite direction (Na and K pump)
vesicular transport
use membrane-bound vesicles to move bulk substances into or out of the cell
endocytosis-movement of material into the cell
-phagocytosis-cell eating
-pinocytosis-cell drinking
exocytosis-movement of material out of the cell
phospholipid bilayer anatomy
polar heads
non-polar tails
cholesterol in between makes the membrane impermeable
-stiffens the molecule
semi-permeable
allows only certain substance to pass
non-polar moves via simple diffusion
polar move with proteins
mitosis
parent cell divides into 2 identical daughter cells
prophase-chromatin condenses nucleus fragments, spindle apparatus forms
metaphase-chromosomes line up in the middle
anaphase-sister chromatids are pulled to opposite sides, cytokinesis begins
telophase-chromatin uncoils, nucleus reforms, spindle apparatus disappears
epithelia
line free surface of the body any substance entering or leaving the body must cross this cellular, little matrix, avascular anchored via basement membrane leaky and tight
simple squamous location
blood vessel,s heart
simple cuboidal location
kidney tubules, glands and their ducts, thyroid
simple columnar location
lines GI tract
pseudostratified ciliated columnar location
respiratory passageway
stratified squamous keratinized location
epidermis of skin
stratified squamous non-keratinized location
mouth, esophagus, vagina, anus
transitional location
bladder, uterus, urethra
stratified cuboidal location
sweat, mammary, and ovarian follicles
connective tissue
extensive extracellular matrix with widely scattered cells that secrete and modify the matrix
collagen
most abundant CT
flexible but inelastic
elastin
allows stretching and recoil
reticular
thin, short, branching collagen fibers
areolar CT
loose CT
lots of matrices
fibroblasts, macrophages
forms lamina propria, packages organs, surrounds capillaries
adipose CT
loose CT
little matrix, lots of cells, highly vascular
triglyceride storage, insulation, supports and protects organs
reticular CT
loose CT
network of reticular fibers and reticulocytes
forms stroma for soft organs
lymph nodes, spleen, red bone marrow
dense regular CT
parallel bundles of collagen with little ground substance
resists pulling forces
ligaments and tendons
dense irregular CT
fibers run in many places
the dermis of the skin and joint capsules
hyaline cartilage
most abundant
supportive, reduce friction, compression forces
ends of long bones, costal cartilages, nose, trachea, larynx
elastic cartilage
allows flexibility while maintaining shape
external ear and epiglottis
fibrocartilage
lots of collagen
shock absorber
pubic symphysis, intervertebral discs, the meniscus of the knee
skeletal muscle
attached to the skeleton, generate movement and heat
striated, multinucleated, voluntary
cardiac muscle tissue
heart propels blood
striated, branched, uninucleate, intercalated discs, involuntary
smooth muscle tissue
walls of hollow organs
fusiform, uninucleate, lack striations, involuntary
nervous tissue
brain, spinal cord, nerves
transmit electrical impulses
neurons and glial cells
layers of the epidermis
stratum basale-actively mitotic stem cells on top of the basement membrane contain melanocytes
stratum spinosum-keratinocytes, dendritic cells
stratum granulosum-3-5 layers of flattened cells, keratinization takes place, granules
stratum lucidum-thick skin only in palms and feet, dead keratinocytes
stratum corneum-20-30 layers of dead cells, protect
layers of dermis
papillary layer-superficial, areolar CT
-dermal papillae-projections into the epidermis, blood vessels, and Meisner’s corpuscles, fingerprints, create friction
reticular layer-dense irregular CT, tension lines
sweat glands
eccrine-most numerous, empty through a pore, palms, soles of feet, forehead, thermoregulation
apocrine-empty into a hair follicle, axilla, and anogenital region
sebaceous glands
located in the head, face, neck, chest
secrete sebum into a hair follicle
hair
shaft-part we see, keratinized
root-embedded, undergoing keratinization
follicle-invagination of the epidermis into the dermis
melanocytes for color
nails
protection and tools
free edge, body, root
long bone
longer than wide
humerus, femur, radius, ulna
diaphysis-shaft, compact bone, yellow bone marrow
epiphysis-ends of the long bone
spongy bone-houses red bone marrow
periosteum-CT surrounding outside of the bone
endosteum-CT lining medullary cavity
histology of compact bone
osteons
the center contains nerves and blood vessels connected via Volkman’s canals
osteocytes in lacunae that communicate via canaliculi
concentric lamellae-rings of osteons
vascularized
intramembranous ossification
formation of flat bones from mesenchymal tissue forms ossification center -cluster of mesenchymal cells = osteoblasts osteoid secreted and calcified -osteocytes spongy bone and periosteum form -create trabeculae compact bone replaces the spongy bone -redbone marrow forms
endochondral ossification
forms bone from hyaline cartilage
bony collar around the hyaline model
-osteoblasts secrete osteoid
central cartilage calcified
-chondrocytes die
-cartilage that’s healthy elongates
periosteal bud invades the internal cavity and spongy bone forms
-osteoclasts erode calcified matrix
-osteoblasts secrete osteoid = trabeculae
diaphysis elongates and the medullary cavity forms
secondary ossification center at the epiphysis
-no medullary cavity formed
-cartilage remains between epiphysis and diaphysis forming epiphyseal plate
maintaining blood calcium homeostasis
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Wolff’s Law
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fibrous joint
joined by fibrous CT no movement sutures of the skull syndesmosis or radius/ulna and tibia/fibula gomphosis-teeth
cartilaginous joint
joined by cartilage synchondrosis-connected via hyaline -between diaphysis and epiphysis, no movement symphysis-connected via fibrocartilage -pubic symphysis, little movement
synovial joint
freely movable
shoulder, knee, hip
flexion
decrese angle
extension
increase the angle
hyperextension
increasing angle beyond 180