Fibroadenoma

Question 1

Definition

Answer 1

Benign breast tumours that arise from the proliferation of stromal and epithelial connective tissue cells within the breast tissue.

Question 2

Epidemiology and Risk factors

Answer 2

• 14-35 years
• Pre-menopausal
• Pregnancy
• Use of COCP
• Presence of mediator complex subunit 12 (MED12) gene

Question 3

Signs

Answer 3

Mass:
- Smooth
- Rubbery
- Mobile
- Regular borders

Question 4

Symptoms

Answer 4

Painless breast lump
Usually unilateral

Question 5

Diagnosis

Answer 5

• Mammogram: well-circumscribed, oval hypodense or isodense mass, may contain calcifications
• Breast USS: well-circumscribed, round to ovoid, or macrolobulated mass with generally uniform hypoechogenicity
  Consider: Core needle biopsy: stromal and epithelial cells

Question 6

Treatment

Answer 6

No treatment as often regress spontaneously
Surgery removed for cosmetic reasons if large:
- Lumpectomy: surgical removal of the fibroadenoma
- Cryoablation : cryoprobe used to freeze and destroy the fibroadenoma