Breast cancer types Flashcards
1
Q
In situ carcinomas
A
- Ductal carcinoma in situ
- Lobular carcinoma in situ
2
Q
Ductal carcinoma in situ
A
- Does not produce a mass but is often detected by calcification on mammography
- Histology: Malignant proliferation of ductal cells without invasion of the basement membrane.
- Subtypes: comedo and non-comedo subtypes with the former involving high-grade cells with central necrosis
3
Q
Lobular carcinoma in situ
A
- Mammography normal - due to lack of E-Catherin it grows profusely in sheets not into a lump
- Often discovered incidentally when the breast is biopsied for alternate reasons
- Histology: Malignant proliferation of cells in lobules without invasion of the basement membrane
- Characterised by loss of E-cadherin
4
Q
Types of invasive carcinoma
A
- Invasive carcinoma of no special type (NST)
- Tubular carcinoma
- Mucinous carcinoma
- Medullary carcinoma
- Inflammatory carcinoma
- Invasive lobular carcinoma
5
Q
Invasive carcinoma of no special type (NST)
A
- MC invasive cancer
- Presents with mass on screening
- Unilateral and unifocal
- Histology = Malignant duct-like structures without any other features.
6
Q
Tubular carcinoma
A
- No palpable lump but identified on screening
- Well-differentiated tubules
Traditionally considered to be a subtype of invasive ductal carcinoma
7
Q
Mucinous carcinoma
A
- May present with palpable mass
- Histology: Tumour cells in a ‘lake’ of mucin
- Traditionally considered to be a subtype of invasive ductal carcinoma
8
Q
Inflammatory carcinoma
A
- Mimics mastitis: inflamed, swollen breast, Peau d’orange
- Histology: Characteristic by infiltration of dermal lymphatics
- Can arise from any subtype, but most typically arsies from invasive ductal carcinoma
9
Q
Invasive lobular carcinoma
A
- More difficult to detect on mammography due to linear growth compared to NST
- Bilateral and multifocal
- Histology: Cells grow in a single-file
- Lack of E-cadherin
