Fexofenadine

Question 1

What is the generic name of fexofenadine?

Answer 1

Fexofenadine hydrochloride

Question 2

What type of medication is fexofenadine?

Answer 2

An anti-histamine

Question 3

What is the mechanism of action of fexofenadine?

Answer 3

Fexofenadine is a selectively peripheral H1-Antagonist. It binds to and stabilizes the inactive form of the receptor, preventing its activation.

The H1 histamine receptor is responsible for mediating hypersensitivity and allergic reactions. Exposure to an allergen results in degranulation of mast cells and basophils, which then release histamine and other inflammatory mediators. Histamine binds to, and activates, H1 receptors, which results in further release of pro-inflammatory cytokines, such as interleukins, from basophils and mast cells.

Question 4

What is the NSW Ambulance use of fexofenadine?

Answer 4

Anaphylaxis and allergic reaction (localised, mild allergic reaction only)

Question 5

What are the adverse effects of fexofenadine?

Answer 5

• Headache
• Nausea
• Dizziness
• Dry mouth

Question 6

What are the contraindications of fexofenadine?

Answer 6

• Previous administration of fexofenadine within 24hrs
• Allergy or hypersensitivity to fexofenadine
• Patients < 12yrs old

Question 7

What is the preparation and dosage of fexofenadine?

Answer 7

• Preparation: 180mg tablet
• Dosage:
  
  • 12yrs old or more: 180mg
  • Repeat: Nil
  • Max Total Dose: 180mg