Fertility control Flashcards

1
Q

COCP that does not follow the 7d additional precautions rule?

A

Qlaira® requires 9 days of additional contraceptive precautions

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1
Q

COCP that does not follow the d1-5 with no additional precautions rule?

A

Estradiol-containing combined oral contraceptives (Qlaira and Zoley) require additional precautions if started after Day 1

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2
Q

Problematic bleeding on hormonal contraception: investigations

A

STI test
Cervical screening
UPT

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3
Q

Problematic bleeding on hormonal contraception: when not to examine

A

no risk factors for STIs,

no concurrent symptoms suggestive of underlying causes,

they are participating in an NHSCSP,

and have had no more than 3 months of problematic bleeding.

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4
Q

Problematic bleeding on hormonal contraception: when to endometrial biopsy

A

in women aged ≥45 years or in women aged <45 years with risk factors for endometrial cancer who have persistent problematic bleeding after the first 3 months of use of a method or who present with a
change in bleeding pattern

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5
Q

Bleeding on COC

A

For women using a COC the lowest dose of ethinylestradiol (EE) to provide good cycle
control should be used. However, the dose of EE can be increased to a maximum of 35 µg to provide good cycle control.

Although DONT change within the first 3 months.

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6
Q

Bleeding on POP

A

There is no evidence that changing the type and dose of POP will improve problematic bleeding; bleeding patterns may vary with different POP
preparations and this may help some individuals.

PO-injectable: mefenamic acid 500 mg twice daily (or as licensed up to three times daily) for 5 days.

PO-injectable, implant or
IUS: COC may be tried for 3 months (this can be used in the usual cyclic manner
or continuously without a pill-free interval and is outside the product licence).

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7
Q

Upper arm anatomy

A

Separated into anterior (flexor) and posterior (extensor) compartments by fascia, bones and ligaments.

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8
Q

Arm: Anterior compartment

A

contains 3 muscles:

(1) Biceps brachii:
*Flexor of the forearm at the elbow joint
*Supinator of the forearm
*Accessory flexor of arm at glenohumeral joint
*Biceps tendon reflex tests C6

(2) Brachialis:
*Flexor of the forearm at the elbow joint

(3) Coracobrachialis:
*Flexor of arm at glenohumeral joint

All predominantly innervated by musculocutaneous nerve

Brachialis has small component laterally which is innervated by the radial nerve

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9
Q

Posterior compartment

A

contains only the triceps brachii

Innervated by the radial nerve

Extensor action on the forearm at the elbow

Triceps tendon reflex tests C7

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10
Q

Arteries in the arm

A

Aortic arch -> gives rise to Brachiocephalic trunk on the right -> right subclavian and common carotid

On the left, the subclavian and common carotid arise directly from the aortic arch

**Remember ABCs – Aorta: Brachiocephalic, Common carotid, Subclavian **

The subclavian artery -> (gives rise to ) axillary artery -> (becomes the) brachial artery when passes beyond the lower border of teres major -> (becomes the) radial and ulnar arteries distal to the elbow

Brachial artery gives off profunda brachii, which passes into and supplies the posterior compartment of the arm (which it enters alongside the radial nerve)
(Profunda brachii passes along the radial groove and anastomoses with the posterior circumflex humeral artery)

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11
Q

Veins in the arm

A

Includes the superficial veins (cephalic and basilic) and deep veins (brachial and axillary)

Veins of the arm -> (become the) subclavian vein -> (joins with the jugular veins) brachiocephalic vein -> (right and left brachiocephalic veins merge) superior vena cava -> (empties into) right atria

The basilic vein passes vertically in the medial distal half of the arm
*Penetrates the deep fascia
*Becomes the axillary vein at the border of the teres major

The cephalic vein passes on the anterolateral aspect of the arm
*Proximally, it joins with the axillary vein

The paired brachial veins pass along the medial and lateral sides of the brachial artery

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12
Q

Nerves of the arm

A

Musculocutaneous (C5 - C7)
Axillary (C5, C6)
Median (C5-T1)
Radial (C6-T1)
Ulnar (C8, T1)

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13
Q

Nerve injury from Implant INSERTION

A

Ulnar nerve damage: If damaged proximally (as we would from implants) - when try to make a fist hand resembles an ‘OK sign’ as cannot bend the medial 2 digits

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14
Q

Nerve injury from Implant removal

A

median, cutaneous and ulnar nerves

Ulnar nerve damage: If damaged proximally (as we would from implants) - when try to make a fist hand resembles an ‘OK sign’ as cannot bend the medial 2 digits

Median nerve: If damaged proximally (as could occur with implant removal) when asked to make a fist - hand of benediction (unable to bend lateral 3 digits)

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15
Q

Study which led FSRH to change their guidance used cadaveric dissection of 40 cadavers.

A

In elbow flexion the ulnar nerve moves towards the sulcal line (correct position for insertion/ removal – ulnar nerve out of the way)

At 2-3cm posterior to the sulcal line basilic vein (40%), ulnar nerve (40% - though deep), MEDIAL BRACHIAL CUTANEOUS NERVE of the arm (57.5%) and medial antebrachial cutaneous nerve of forearm (17.5%) were localised with only 25% of the arms dissected being free from neurovascular structures at this location.

At the 3-5cm window no cadavers had significant neurovascular structures (only triceps muscle more deeply)

16
Q

Upper limb arteries

A

ABCs
Ascending aorta/ aortic arch
Brachiocephalic (r) (– R common carotid and R subclavian)
Left Common carotid
L subclavian

Then another ABC
(Axillary, Brachial, Post circumflex)

Subclavian branches into 4, one of which is the…
Axillary which (after giving off 3 branches) becomes the…
Brachial which becomes the Ulnar and Radial aa, and the Profunda Brachii.

Another branch of the Axillary is the posterior circumflex humeral. This forms an anastamosis with the Profunda Brachii.

17
Q

Upper limb veins

A

Superficial veins are the cephalic v (radial, anterolat) and the basilic (ulnar, medial BUM).

There is an anastomosis through these at the AC region called the median antecubital vein.

Deep veins are radial and ulnar veins, which come together to form the
Brachial veins (paired).

The basilar vein becomes the axillary vein. The brachial vein empties into this.

The cephalic and axillary veins feed into / form the subclavian veins.

The subclavian veins merge with the jugulars to form the brachiocephalic.

R and L brachiocephalic come together to form the SVC which feeds into the RA.

18
Q

Testosterone based progestins

A

Levonorgestrel

Ethynodiol diacetate

Gestodene

E
Norethindrone / acetate
Norethisterone

N
Nomegestrol acetate (in Zoely)
Norgestimate à Norelgestromin

D
Dienogest* (hybrid, in Qlaira)
Desogestrel à etonogestrel

19
Q

Progesterone based progestins

A

Medroxyprogesterone acetate

Chlormadinone acetate

Cyproterone acetate

Nestorone (segesterone acetate – male contraceptive!)

20
Q

Spironolactone based progestins

A

Drosperinone

21
Q

1st generation progestins

A

Norethisterone

Cyproterone acetate

Medroxyprogesterone

22
Q

2nd generation progestins

A

Levonorgestrel (Microgynon/ other first like COCP options)

Norgestrel

23
Q
A
24
Q

3rd generation progestins

A

Desogestrel (Mercilon, Marvelon)

Gestodene (Femodette, Femodene)

Norgestimate (Cilest)

25
Q

4th generation progestins

A

Drosperinone (Yasmin)
Dienogest (Qlaira)

26
Q
A
27
Q

Semen Normal values:

A

Ejaculate volume >=1.5ml (average 2-5ml)
>=15 millions spermatozoa/ml

> =39 million sperm/ ejaculate

pH >=7.2

Motility of 40% + (progressive motility 32%+)

58%+ live sperm (vitality)

4%+ normal sperm morphology

Fenton Millard (15 mil, 1.5/ml) was running down the motorway.

It was the M40 progressed from M32 last year (Motility of 40%+, progressive motility 32%)

Vitality peaked at 58mph (58%+ live sperm)

His running style was unpredictable, had 4+ morphologies depending on the wind! (4%+ normal sperm morphology)

He stopped at 7/1+1 for a P (pH > equal 7.2)

28
Q
A