24/03

Question 1

What are prostaglandins synthesised from and how do they work?

Answer 1

Synthesised from aracnidonic acid (FA)
Work by G protein coupoled receptors on cell surfaces (F2a) - on uterine - phospholipase C - Ca2= and activation of myosin –> myometrial contractions

Question 2

Drugs that prolong Qt

Answer 2

T - Thiazides
O - Olanzapine
O - Opioids
Q - Quinidine (Class IA antiarrhythmics)
Q - Quinolones (Fluoroquinolones antibiotics)
R - Risperidone (Typical and atypical antipsychotics)
S - Sotalol (Class III antiarrhythmic)
A - Antihistaminics
D - antiDepressants like TCAs
E - Erythromycin (Macrolide antibiotics)
S - SSRI antidepressants

Question 3

When does RPR become positive after Sts infection

Answer 3

6 weeks
(peaks at 1-2 years)

Question 4

Precicious puberty causes

Answer 4

1. GnRH dependant
   » Idiopathic
   » Kisspeptin mutation
   » Hypothalamic hamartoma (triad: PP, laugh seziures, developmental delay)
2. GnRH indep
   » CAH
   » Granulosa cell tumour
   » Adenocort tumour
   » Mccune albright synd

Question 5

Key Enzyme inducers
Enzyme inhibitors
+/- teratogen

Answer 5

Erythromycin = inhibitor
Sodium valproate = inhibitor plus teratogen

Lithium = teratogen

Phenytoin = inducer + teratogen
Rifamicin = inducer

Question 6

Vasc disease UKMEC

Answer 6

Including TIA

CHC 4
DMPA 3
PO-only 2
Cu 1

Question 7

MRKH

Answer 7

WNT 4 chromosome 1
Normal FSH LH E2

Question 8

Oligomenorrhea

Answer 8

Any time >90 d
Year 1-3 post menarch <31 or >45
Year 3+ post menarch <21 >35

Question 9

SS RNA

Answer 9

Hep a, c, d, e
Rubella,
Zika
HIV

Question 10

DS RNA

Answer 10

Rota

Question 11

SS DNA

Answer 11

Parovirus B19

Question 12

DS DNA

Answer 12

Hep B
CMV
HPV
VZV
HSV1/2
EB