Female Reproductive Hormones Flashcards
Female Sex Hormones
Progesterones
Estrogens
Most common Female Reproductive Hormones
17β-estradiol
Progesterone
Secondary effects of the Female Reproductive Hormones
Breast Development
Wider Hips
Rounder Facial Features
Fill out the key features of a follicle
Fill out the process of Estrogen Synthesis
Estrogen Synthesis
Enzyme ____ converts cholesterol to prognenolone
desmolase
Estrogen Synthesis
Enzyme ____ converts androstenedione to 17β-estradiol
aromatase
Where may Androstenodione be produced in women?
Adrenal Gland
Refer to Male Reproductive Hormones Flashcard 4
Besides Ovarian Cells, where may aromatase be found?
Adipose Tissue
Liver
Pancreas
Bone
Adrenal Glands
Skin
Brain
Breasts
Fill out the process of Progesterone Synthesis
The pulsatile release of ____ from the ____ is responsible for reproductive changes
__GnRH__
__Hypothalamus__
What factors affect pulsatile release of GnRH?
Environment
Age
Time of month
What body functions may be affected by Estrogen and Progesterone?
Transcription
Translation
Similar pathway to other Steroid Hormones
How may Estrogen and Progesterone exert their action?
Internalization → Binding to Intracellular Receptors → Nuclear Binding
How are progesterone and estrogen transported around the body?
Bound to Sex-Binding Hormone Globulins
Produced in liver
What are ER and PR-positive breast cancers?
Means Estrogen and Progesterone stimulate cancer cell division
How can ER and PR-positive breast cancers treated?
Tamoxifen blocks hormone receptors
Functions of Estrogen
Initiates and promotes female characteristics
Developing and maintaining female reproductive tracts
Develops and maintains female secondary characteristics
Induces Progesterone receptors in several tissue (uterus, brain, breast)
Preparation for and maintaining pregnancy
Increasing HDL and decreasing LDL cholesterol
Increasing bone mass
What changes may estrogen promote to enable preparation for pregnancy?
Endometrial Proliferation
Breast Ductal System for Lactation
How may estradiol deficiency cause osteoporosis?
Decreases apoptosis of osteoclasts
Increases activity of osteoclasts
Functions of Progesterone
Endometrium to Secretory Endometrium
Prepares Uterus for pregnancy
Increases body temperature
What is the Ovulatory cycle?
Cycle of events in preparation for ovulation
What is the Menstrual Cycle?
Cyclical Changes in the Uterine Endometrium
Aligns with Ovulatory Cycle
What is atresia of the ova?
Steady degeneration of ova reducing their number
What are Ovarian Follicles?
Oval structures where oocytes reside and develop
What are the hormones of the Menstrual Cycle?
Estradiol
Estrogen
Progesterone
What is the effect of Estradiol in the Menstrual Cycle?
Endometrium Thickening
Formation of Tubular Glands
What is the effect of Estrogen in the Menstrual Cycle?
Progesterone Receptors on Endometrial Cells
What is the effect of Progesterone in the Menstrual Cycle?
Glands become Tortuous
Decreased Mitotic Activity
Increased Glandular Secretions
What are the phases of the Ovulatory Cycle?
Follicular Phase
Luteal Phase
What are the phases of the Menstrual Cycle?
Menses
Proliferative
Secretory
Fill out the following diagram on Estradiol Negative Feedback
Fill out the following diagram on Progesterone Negative Feedback
Which hormone from the ovary inhibits the anterior pituitary release of FSH?
Inhibin
How are FSH and LH involved in the Ovulatory and Menstrual Cycle?
FSH+LH involved in Estrogen Synthesis
FSH = Stimulate Follicle Maturation before Ovulation
LH = Surge of LH incites ovulation
What produces the Human Chorionic Gonadotropin (hCG)?
Developing embryo
Function of hCG
Prevents degradation of Corpus Luteum which stimulates Progesterone Production to maintain Endometrium
Ovulatory Cycle
Timings of each phase
Follicular Phase (Days 1-14)
Ovulation (Day 14)
Luteal Phase (Days 15-28)
Ovulatory Cycle
Follicular Phase Events
Ovulatory Cycle
Ovulation marks the end of the ____ and the beginning of the ____
__follicular phase__
__luteal phase__
Ovulatory Cycle
Ovulation Events
Ovulatory Cycle
Luteal Phase Events
Menstrual Cycle
Timings of each phase
Menstrual Phase (Days 1-4)
Proliferative Phase (Days 4-14)
Secretory Phase (Days 15-28)
Menstrual Cycle
What happens during the Menstrual Phase?
Menses
Menstrual Cycle
What causes the Menstrual Phase?
Drop in Estrogen and Progesterone
Menstrual Cycle
What causes the menses?
Fragmentation of Endometrial Glands
Thrombosis
Inflammatory Cell Infiltration
Degeneration of Endometrial Stroma
Menstrual Cycle
Proliferative Phase Events
Menstrual Events
Secretory Phase Events