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USMLE-rx > feb 21st > Flashcards

feb 21st Flashcards

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USMLE® Step 1 flashcards
1
Q

What is the mnemonic for SSRI’s?

A 
Flashback Paralyze Senior Citizens 
Fluoxetine 
Paroxetine
Sertraline
Citalopram
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2
Q

TCA’s can cause Tri C’s which means what?

A

Convulsions
Cardiotoxicity
Coma

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3
Q

How do TCA cause cardiotoxicity?

A

due to Na+ channel inhibition

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4
Q

how do you treat arrhythmias associated with TCA?

A

Sodium bicarb

NaHCo3

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5
Q

What has more affects of anticholinergics? TCA’s or SSRI’s?

A

TCA’s

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6
Q

Pt has CF and they are 6 years old what is the most likely cause of their recurrent pneumonia?

A

Staph

- after 21 is pseudomonas

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7
Q

What are the recommended treatments for pseudomonas infections?

A

Aminoglycosides
Flouroquinolones
Piperacillin

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8
Q

What are the aminoglycosides?

A 
Neomycin
Streptomycin
Gentimicin
Tobramycin
Amikacin
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9
Q

What is a common cause of hyperventilation in respiratory alkalosis?

A

Panic attacks

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10
Q

What is respiratory and metabolic alkalosis in terms of numbers?

A

<36 mmHg Co2 for respiratory

>28 bicarb For metabolic

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11
Q

Pts has dementia and loads of loose stools. Where should the rash be? DX

A

Casal necklace
Gloving/sun exposed limbs
-Pellegra
-

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12
Q

What is Hartnup disease?

A

Defect in neutral AA transporters in PCT and Enterocytes

  • Leads to def in tryptophan
  • Leads to unhappiness and pellegra
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13
Q

How does one treat harnup disease?

A

high protein diet and nicotinic acid

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14
Q

What sort of foods is niacin found/

A 
Beef
Chicken
Nuts
Legumes 
Fish
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15
Q

What are the amides local anesthetics?

A

They have two I’s
Lidocaine
Bupivacaine
Mepivicaine

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16
Q

What are the esters?

A 
They dont have two I's
Cocaine 
Procaine
Tetracaine
Benzocaine
17
Q

Which one the amine local anesthetics causes severe cardiotoxicity?

A

Bupivacaine

18
Q

In first order kinetics how many half lives does it take to reach steady state?

A

4-5

19
Q

How many half lives does it take to reach 90% steady state?

A

3.3

20
Q

How does one calculate t1/2?

A

.7*Vd/Clearance

21
Q

What is steady state of a drug?

A

When rate of excretion is equal to the rate of input

22
Q

What cancers does methotrexate treat?

A

Leukemias
Choriocarcinoma
Lymphomas
Sarcomas

23
Q

Pt presents with mouth sores. She has a liposarcoma. She has myelosuppression, icterus and sores in her mouth. What drug is she on and what is the treatment for her sx’s?

A

Methotrexate

- Leucovorin

24
Q

What is leucovorin?

A

Reduced folic acid

- Folinic acid

USMLE-rx (9 decks)

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