Feb 19th Flashcards

(26 cards)

1
Q

What causes the pseudomembranous colitis found in C. Difficile?

A
  • Actin depolymerization by exotoxin B.
  • leads to necrosis and death and eventually the yellow gray exudate that is the membrane.
  • AKA cytotoxin
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2
Q

What are Meissener Corpuscles?

A
- Sensory receptors found in HAIRLESS areas of body 
Light touch 
fine touch
Dynamic 
Positional sense
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3
Q

Where Are Meissner corpuscles found?

A

Immediately below the epidermis

  • Genitalia
  • Palms of hands
  • Soles of feet
  • Eyelids
  • Lips
  • Fingertips
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4
Q

What is the mnemonic for the epidermal layers of skin?

A

Californians Like girls in String Bikinis

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5
Q

What layer of the common 5 is typically only found in the palms and soles of feet?

A

Lucidum

- Luke has thick skin and thus he has an extra layer

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6
Q

Where do testes drain their lymph? What else drains here?

A

Para-aortic

- Kidneys, uterus, ovaries

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7
Q

Where does the scrotum drain its lymph? What else goes here?

A

Superficial inguinal

  • Skin below umbilicus (except popliteal)
  • Anus below pectinate line
  • vulva
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8
Q

Where does lymph in the popliteal LN get its drainage from?

A

Dorsolateral foot

Posterior calf

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9
Q

If we were to have a venous ulcer that got infected where would the enlarged LN’s be? how about arterial?

A

Venous would be Superficial inguinal

Arterial would be popliteal

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10
Q

What is the MOA of Bacitracin?

A

Peptidoglycan synthesis inhibitor

- inhibits the carrier of peptidoglycan building blocks

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11
Q

Why is Bacitracin only used topically?

A

Extremely nephrotoxic

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12
Q

What is the MOA of Daptomycin?

A

Lipopeptide that disrupts cell membrane of Gram + organisms

  • loss of membrane potential
  • this causes them to be unable to continue with nucleotide synthesis
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13
Q

What are the uses of Daptomycin? Not used for?

A

MRSA, bacteremia, Endocarditis and VRE

- Not used for Pneumonia because it is inhibited by surfactant

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14
Q

What is the treatment for RSV?

A

Ribavirin

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15
Q

What is the MOA of Ribavirin?

A

Inhibits Inosine Monophosphate dehydrogenase

  • IMP–> GMP
  • Thus inhibits the production of Guanine
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16
Q

What are the SE of Ribavirin?

A

Hemolytic anemia

Severe teratogen

17
Q

What is the MOA of acyclovir? Famciclovir and valacyclovir?

A

Guanosine analog

  • Activated (phosphorylated by viral Thymidine kinase)
  • Thus few adverse affects
  • Causes chain termination and inhibitors viral DNA synthesis
18
Q

What is the disease called from S. mansoni?

A

Katayama fever

19
Q

When should you suspect Katayama fever?

A

Healthy person who traveled to South A, Sub Saharan Africa, Middle east who presents with:
Fever
Hepatosplenomegaly
Peripheral eosinophilia

20
Q

What is the classic triad for Job syndrome?

A
  1. Staph infections abscesses
  2. Elevated IgE
  3. Pruritic Eczema
21
Q

What is the mutation and inheritance of Job syndrome?

A

Deficient Th17 cells due to STAT3 TF mutation

- Autosomal dominant

22
Q

What is decreased in Job syndrome? What is another name for it?

A

INF-y decrease
IgE increased
- Autosomal dominant hyper-IgE syndrome

23
Q

What are the inferior leads?

A

II, III and avF

24
Q

What does the posterior descending artery supply?

A

Posterior 1/3 of interventricular septum

Inferior and posterior ventricles

25
What supplies the SA and AV node?
RCA
26
How do Jahovah's witnesses children rule in terms of needed blood?
Religious reasons for blood transfusions can be denied by the parents for themselves - However they cannot deny the child of a needed blood transfusion - Medical ethics state and local courts will rule in this manner