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Farma final > Farmacos quimioterapéutico > Flashcards

Farmacos quimioterapéutico Flashcards

1
Q

quimioterapia se utiliza

A

tumor solido adyuvante
hematologicos eje tx
ambos como paliativos

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2
Q

tratamiento cancer

A

cirugía
quimio (frenar la taza de division, es sistemica)
radio
inmunoterapia

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3
Q

MoA

A

inhibe las division celulas neoplasicos y sanos

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4
Q

puede causar toxicidad

A

médula ósea (mielodepresión), en epitelio digestivo (mucositis), en folículos pilosos (alopecia).

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5
Q

EA zona de gatillo

A

nausea, vomito y anorexia

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6
Q

toxicidad en organos

A

corazón (arritmias y miopatias), hígado, pulmón y riñón

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7
Q

SNC

A

Encefalopatias

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8
Q

la mayoria actuan en la fase

A

S o la metafase

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9
Q

quimioterapeuticos inhibidores purinas y pirimidinas

A
  • Mercaptopurina, fludarabina, clofarabina
  • Metotrexato, pemetrexed
  • 5-fluorouracilo, gemcitabina
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10
Q

mercaptopurina MoA

A

inhibe a las purinas

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11
Q

metrotezato MoA

A

inhibe pirimidas y purinas

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12
Q

5-fluorouracilo MoA

A

inhibe pirimidinas

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13
Q

medicamentos que evitan el paso de los nucleotidos al ADN

A

Hidroxiurea, citarabina

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14
Q

melfalan agentes alquilantes o mostazas MoA

A

daña directamente al ADN

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15
Q

ciclofosfamida agentes alquilantes o mostazas MoA

A

daña directamente al ADN

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16
Q

Doxorubicina, daunorubicina, idarubicina,
mitoxantrona, bleomicina, dactinomicina

A

agentes citotoxicos inhiben ARN mensajeros

17
Q

asparaginasa MoA

A

dañan al aminoacido

18
Q

Vincristina MoA

A

inhibidores mitoticos se unen a tubulinas - no hay division celular

19
Q

enzimaticos

A

los que terminan en ib
Imatinib, dasatinib, nilotinib, erlotinib, geftinib, sunitinib, sorafenib, lapatinib, vemurafenib, ibrutinib, bortezomib.

20
Q

anticuerpos nucleares

A

Cetuximab, bevacizumab, nivolumab, rituximab, alemtuzumab, ipilimumab, trastuzumab,

21
Q
A

Farma final (47 decks)

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