dislipidemias estatinas Flashcards

1
Q

cuales son las estatinas

A

Atorvastatina. Rosuvastatina. Simvastatina. Pravastatina. Pitavastatina.

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2
Q

mecanismo de accion de las estatinas

A

Inhibe a la HMG-CoA reductasa (enzima limitante de la síntesis de colesterol)a disminuye síntesis de colesterol.

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3
Q

estimula la formacion de

A

receptores del LDL y VLDL

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4
Q

estimula la formación de

A

HDL

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5
Q

tienen multiples efectos

A

pleitropicos (antitrombotico, antioxidativo, antiinflamatorio y disminuye lipidos)

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6
Q

indicaciones

A

dislipidemias
prevencion primaria: disminuye ECV

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7
Q

grupo 1 indicaciones estatinas

A

Pacientes ECV

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8
Q

grupo 2 indicaciones estatinas

A

pacientes >190 LDL

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9
Q

grupo 3 indicaciones de estatinas

A

pacientes con diabetes LDL >70

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10
Q

grupo 4 indicaciones de estatinas

A

Px con SCORE > 7.5% y LDL > 70 mg/dl.

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11
Q

Pitavastatina no se metaboliza por

A

citocromo P450

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12
Q

Atorvastatina, simvastatina son metabolizadas por

A

CYP3A4

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13
Q

EA

A

estreñimiento, diarrea, pirosis, hepatitis, aumenta el risgo de diabetes,

mialgia –> mioitis —> rabdomiolisis (uso de fibratos y dosis altas)

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14
Q

categoria

A

D

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