Fall Pharm Quiz 1 Flashcards
What is a schedule II drug?
Drugs with high abuse potential and accepted medical use
What is a schedule I drug?
Drugs that have high abuse potential and no accepted medical use
List the four basic properties of pharmecokinetics
- Absorbtion- from administration to the blood stream
- Distribution- from absorption to target tissue
- Metabolism- enzymatic alteration of drugs structure
- Excretion- the removal of drugs and drug metabolites from body
What is an enteric coated preparation?
designed to pass through the stomach and not be absorbed until reaching the intestines
What are the three main factors affecting distribution?
- blood flow to the target tissue.
- the ability of the drug to exit the vasculature.
- the ability of the drug to affect the target cell.
Name two situations that alter the drugs ability to exit the vasculature system
- Protein binding
2. Blood brain barrier
What is a pro drug?
A drug that is not active until after it has been metabolized by the liver.
What is bio-availability?
The ability if a drug to reach the systemic circulation from its site of administration.
What is MEC?
Minimum effective concentration
Plasma drug levels below which therapeutic effects don’t occur
What is toxic concentration?
Plasma drug levels at which toxic drug levels occur
What are the four primary receptor families?
- Cell membrane embedded enzymes
- Ligand gated ion channels
- G-protein receptor systems
- Nuclear receptors
What is maximal response?
The maximum effect the drug can produce.
What is relative potency?
The amount of drug that we must give to elicit an effect as compared to another drug.
What is intrinsic activity?
The ability if a drug to activate a receptor upon binding.
What is a competitive antagonist
Binds to receptor without activating it and blocks the binding of other drugs
