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(Other) Board Prep > FA Path Section > Flashcards

FA Path Section Flashcards

1
Q

P-glycoprotein seen in what cancer?

A

Adrenocortical carcinoma

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3
Q

Polycythemia can indicated what neoplastic cancers?

A

RCC, HCC
Hemangioblastoma
Pheo
Leiomyoma

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4
Q

50% of brain tumors are from metastasis, what are the MC sites?

Tumors located where in brain?

A

Lung > breast > melanoma > colon

Gray-white matter junction

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6
Q

1-3 Cancer incidence in women

A

Breast, lung, colon

Lung, breast, colon

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7
Q

What substances cause angiocarcinoma?

A

VAT
Vinyl chloride
Arsenic
Thorotrast

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10
Q

What tumors in MEN1?

What ch. and gene?

A

ALL the Pā€™s
Pituitary adenoma
Pancreatic endocrine tumor (ZE, insulinoma, VIPoma, glucagonma)
Parathyroid adenoma

11, Menin

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11
Q

What carcinogen is the #2 cause of lung cancer after smoke?

A

Radon

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12
Q

What cancers route hematogenously?

A 
Four Carcinomas Route Hematogenously
Follicular thyroid cancer
Choriocarcinoma
RCC
HCC
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14
Q

1-3 Cancer incidence in men

A

Prostate, lung, colon

Lung, prostate, colon

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15
Q

CA-15-3 or CA27-29 marker for what?

A

Breast cancer

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18
Q

Age-related (senile) amyloid due to what?

Predominantly where?

A

Transthyretin

Cardiac ventricles

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19
Q

What tumors in MEN2A?

What gene mutation?

A

Parathyroid herplasia
Medullary thyroid cancer (C cells)
Pheochromacytoma

RET

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22
Q

CA19-9 marker for what?

A

Pancreatic adenocarcinoma

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23
Q

Opsoclonus-myoclonus ataxia syndrome present w/what tumor in children?

Adults?

A

Neuroblastoma

Small cell lung cancer

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24
Q

AFP seen in what cancers?

A

HCC, hepatoblastoma
Yolk sac
Mixed germ cell tumor

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25
Q

What do you need to check for before starting anti-TNF therapy?

Why?

A

Latent Tb

TNF-a maintains granulomas, killing them will cause disseminated Tb infection

27
Q

CEA major associations?

A

Colorectal cancer

Pancreatic cancer

28
Q

High levels of AFP seen in what?

Low?

A

NTD and abdominal wall defect

Down syndrome

30
Q

What causes cholangiocarcinoma?

A

Liver fluke (clonorchis sinesis)

31
Q

What is the only blastic form of metastatic cancer to bone?

A

Prostate cancer

32
Q

CA125 marker for what?

A

Ovarian cancer

35
Q

What tumors in MEN2B?

What gene mutation?

A

Medullary thyroid cancer
Pheochromacytoma
Mucosal neuromas
Marfanoid habitus

RET

36
Q

Fibrils composed of B2-microglobulin is amyloid seen in what patients?

May present how?

A

Dialysis, ESRD pts

Carpal Tunnel syndrome

37
Q

Psammoma bodies found in what tumors?

A 
PSaMM
Papillary carcinoma of thyroid
Serous papillary cystadenocarcinoma of ovary
Meningioma 
Mesothelioma
38
Q

Calcitonin deposition in tumor cells seen where?

A

Medullary carcinoma of the thyroid

39
Q

The heritable form of amyloid is due to what?

A

Transthyretin gene mutation

48
Q

AL amyloid is due to what?

Occurs in what?

Affects what organs?

A

Ig Light chains

Any plasma cell disorder, Multiple myeloma

Many - renal, cardiac, GI, neuro, etc

50
Q

Amyloid deposition to ventricular endomyocardium causes what?

A

Restrictive cardiomyopathy

51
Q

Alzheimer amyloid is described how?

A

B-amyloid protein cleaved from APP

55
Q

What is CD31?

For what stage?

A

PECAM-1

Diapedesis then Migration

56
Q

AA amyloid seen in what?

Fibrils composed of what?

What class?

A

Chronic inflammatory conditions ā€“> R.A., IBD, spondyloarthropathy, familial Mediterranean fever

Amyloid A

Secondary

57
Q

What kind of amyloid is seen in T2DM?

Due to what?

A

Islet amyloid polypeptide (IAPP)

Deposition of amlyin in pancreatic islets

64
Q

What neurons in brain are most susceptible to hypoxia-ischemia?

A

Purkinje cells of cerebellum and pyramidal cells of the hippocampus and neocortex (zones 3, 5, 6)

65
Q

2?

M.G. MC pathology seen with it?

A

B cell hyperplasia

thymoma

(Other) Board Prep (19 decks)

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