Cancer Drugs Flashcards
When giving Azathioprine and 6-MP what do you have to be careful with?
What drugs to avoid with it?
XO inhibitors bc they will greatly increase its dose
Allopurinol, Febuxostat
What drug used to treat stage 4 colorectal cancer (KRAS) and SEs include rash w/elevated LFTS?
MOA?
Cetuximab
Mab against EGFR
What drugs are in ABVD?
Adriamycin (doxorubicin)
Bleomycin
Vincristine
Dacarbazine
Cisplatin MOA?
SE?
Cross-links DNA
Nephrotoxic, ototoxic, peripheral neuropathy
MOA of trastuzumab (herceptin)?
SE?
Mab against HER2 (c-erbB2), Tyr Kinase, tx for breast cancer
Heart damage
What drug is used to treat RCC and colorectal cancer?
MOA?
Bevacizumab
Mab against VEGF
High doses of what drug requires rescue with leucovorin?
Methotrexate
What drugs treat multiple myeloma and mantle cell lymphoma w/side effects of peripheral neuropathy and reactivation of herpes zoster?
MOA?
Arrest cell cycle when?
Bortezomib, carfilzomib
26S proteosome inhibitors
G2-M
What drug inhibits microtubule polymerization?
SE?
Vinca alkaloids - vincristine binds B-tubular
peripheral neuropathy, neurotoxicity
What drug regimen treatment for NHL?
CHOP Cyclophosphamide Hydroxy-danurubicin (Doxorubicin) Oncovorin - Vincristine Prednisone
Busulfan treats what?
SE?
CML
Myelosuppression
Etoposide and teniposide have what MOA?
Tx what?
Act in what cell cycle phase?
SE?
Inhibit topo II –> double strand DNA breaks
Testicular, small cell lung
G2 and S
Myelosuppression, alopecia
MOA of Rasburicase?
tx for what?
Catalyzes uric acid —> allantoin
Tumor lysis syndrome
MOA of bleomycin?
Cell cycle?
induces free radicals, breaks in DNA
G2
Hydroxyurea MOA?
Acts in what cell cycle phase?
Tx what?
Inhibits ribonucleotide reductase, Dec DNA synthesis
S phase
CML, PV, sickle cell
What drug inhibits BRAF oncogene for treatment of melanoma?
What BRAF mutation specifically?
Vemurafenib
V600E
How do alkylating agents work (MOA)?
Name some drugs (4)
Cross-link DNA
Busulfan
Cyclophosphamide, ifosfamide
Nitrosoureas
MOA for cytarabine?
Tx what?
SE?
Inhibits DNA polymerase, S phase
AML
Pancytopenia
MOA of 5-FU?
What is a prodrug with similar activity?
SE?
Inhibits thymidylate synthase
Capecitabine
Myelosuppression, HAND-FOOT syndrome
Which SERM has no risk for endometrial carcinoma?
Which SERM is mainly used for breast cancer treatment?
Raloxifene
Tamoxifen
What drug competitively inhibits DHF reductase and is a folic acid analog?
Must give what when used in high doses?
Cell cycle?
Methotrexate
Leucovorin
S phase
MOA of doxorubicin?
Generates free radicals
Intercalated DNA –> breaks in DNA
What can imatinib treat?
With what gene mutations?
CML, GIST
Tyr kinase, c-kit
What drugs hyperstabilize microtubules?
Tx what?
SE?
Paclitaxel
Ovarian/breast CA
Myelosuppression
Nitrosoureas treat what?
MOA?
What is special about them?
Brain tumors - GBM
Cross-link DNA
Cross BBB into CNS
Irinotecan, topotecan MOA?
Act in what cell cycle phase?
Tx what?
Inhibit topo I –> single strand DNA breaks
S phase and G2
Colon (Irino) and small cell lung (topot)
Cyclophosphamide (ifosfamide) is considered what?
Acts how?
Major SE?
Nitrogen mustard
Cross-links DNA at guanine N-7
Hemorrhagic cystitis, give MESNA
Which 2 drugs are purine analogs that decrease purine syntheses and are activated by HGPRT?
What cell cycle phase?
SEs?
Azathioprine, 6-MP
S phase
Myelosuppression, GI, liver
SE of methotrexate?
Myelosuppression - give leucovorin
Hepatotoxicity
What are the 2 cancer regimens to treat HL?
BEACOPP
ABVD
What drug treats topical BCC?
5-FU
What drugs are in BEACOPP?
Bleomycin, etoposide, doxorubicin (Adriamycin), Cyclophosphamide, Vincristine (Oncovin), Procarbazine, Prednisone
