FA beta-oxydation

Question 1

What happens when glucose is not available?

Answer 1

b-oxidation
(fatty acid oxidation)

Question 2

Why do we need b-oxidation of FA?

Answer 2

-Major source of energy for exercise and fasting (e.g. sleep and starvation)

-Homeostasis (sustained normal cellular functions)

Question 3

Why is it called b-Oxidation?

Answer 3

bond between alpha and beta carbon is cut

Question 4

Step 1 of b-Oxidation

Answer 4

Storage: TAG hydrolysis (adipocyte)

Question 5

Step 1 of b-Oxidation

Answer 5

Diet: FA entry into cells/activation

Question 6

Step 3 of b-oxidation

Answer 6

FA transport into the matrix

Question 7

Step 4

Answer 7

FA b-oxidation to generate Acetyl-CoA

Question 8

FA Activation Occurs via

Answer 8

FA Thiokinase

Question 9

The exergonic hydrolysis of PPi makes reversible reactions using AMP-intermediates

Answer 9

IRREVERSIBLE via the Law of Mass Action (Le Chatelier’s Principle)!!!

Question 10

Reversible Reactions in Glycolysis and CAC are made Irreversible by Law of Mass Action

Answer 10

1) Hydrolysis of PPi (-19.3 kJ/mol)
2) Depletion of products in coupled reactions

Question 11

One Round of b-Oxidation Occurs

Answer 11

in 4 Reactions

Question 12

Peroxisomes functions

Answer 12

-b- oxidation: shorten long chain FA (~ C26:0) to C8:0
-Ether lipids (e.g. plasmalogens)

Question 13

Products of First 3 Cycles of b-Oxidation of Palmitate (per round except last round )

Answer 13

a) 1 acetyl CoA
b) 1 NADH
c) 1 FADH2