Citric Acid Cycle

Question 1

pyruvate dehydrogenase complex

Answer 1

3 enzymes( transacetylase and 2 dehydrogenase)

Question 2

Thiamine (vitamin) deficiency leads to

Answer 2

low TPP(cofactor) & PDH activity and high pyruvate( Beriberi,acidosis)

Question 3

Arsenic & mercury nitrate inhibits

Answer 3

PDH

Question 4

Whenever a substrate gets oxidized by removal of e-(pyruvate),

Answer 4

a product of intermediate gets reduced(NADH)

Question 5

How many carbons does Acetyl-CoA have?

Answer 5

2

Question 6

How many Carbons does Citrate have?

Answer 6

6

Question 7

Citrate Synthase catalyzes…

Answer 7

the first step in the CAC

Question 8

What type of fit does Citrate Synthase have?

Answer 8

induced fit

Question 9

Citrate is isomerized to

Answer 9

Isocitrate via Aconitase

Question 10

Isomerization reactions do not involve

Answer 10

a change in carbon number

Question 11

Isocitrate is converted to alpha-ketoglutarate by

Answer 11

isocitrate dehydrogenase

Question 12

oxidative decarboxylation

Answer 12

isocitrate os first oxidized then decarboxylated by isocitrate DH (Just like pyruvate and acetyl Co-A)

Question 13

alphaKG is oxidatively decarboxylated by

Answer 13

alphaKG DH

Question 14

a-ketogluturate & isocitrate dehydrogenases are huge complexes

Answer 14

similar to pyruvate dehydrogenase

Question 15

Succinyl-CoA has an Energy …

Answer 15

of Hydrolysis slightly higher than ATP

Question 16

Succinate is Acted on by

Answer 16

Succinate DH and Fumarase

Question 17

Malate dehydrogenase regenerates

Answer 17

Oxaloacetate