FA 2016 279-284 Flashcards
Where is ANP released from?
Atrial Myocytes
What is the function of Atrial Naturetic Peptide
constrict the efferent arterioles and dilate affrerent arterioles promoting dieresis in response to increase BP
What contributes to Aldosterone Escape Mechanism?
ANP
what is released from ventricular myocyte in response to increase tension?
BNP
what is used for diagnosing HF?
BNP (Very good negative predictive value)
what is the recombinant form of BNP for treating HF?
Nesiritide.
aortic arch receptors is transmitted via what nerve?
vagus
carotid sinus receptors is transmitted via what nerve?
Glossophrangeal nerve
What take the stimulus from CN9 & CN10 to the medulla?
Sensory Afferent Fibers
what part of the medulla do the sensory afferent fibers take the stimulus to?
solitary nucleus of Tractus
what is the triad of the cushing reaction?
Hypertension, bradycardia and respiratory depression
In a chemoreceptor, what 3 things stimulates aortic arch and carotid sinus?
Inc 02, dec C02 AND dec pH (acidic)
what part of the body does not directly respond to p02?
Brain
Pulmonary Capillary pressure is a good estimator of
LAP
Measured with a right heart Catheter?
PCWP
PCWP>LVDP in what disease?
mitral stenosis
what factors is responsible for Autoregulation in the heart?
Adenosine, NO, Co2 and dec 02
What amino acid makes NO?
arginine
what factor is responsible for auto regulation in the brain?
C02
What factor is responsible for auto regulation in skeletal muscles
CHALK ( c02, H+, Adenosine, Lactate, K+)
auto regulation in the skin
Sympathetic stimulation (most important) temp control
what are the causes of EDEMA?
inc capillary pressure (e.g HF)
dec Plasma protein (e.g Nephrotic syndrome, liver failure & protein malnutrition)
inc capillary permeability (e.g toxins, infection & burns)
increase interstitial fluid colloid pressure (inc lymphatic blockage)
what anomaly is due to the lack of the aorticopulmonary septum formation?
persistant truncus arteriosus
patient with trunks arteriosus usually develop …..
VSD
which of the following is not compatible with life unless a shunt is present?
transposition of the great vessels
what anomaly is formed from the failure of the aorticopulmonary septum to spiral?
Transposition of the great vessels.
Without surgical intervention most infant die within few months of life
Transposition of Great vessels.
Hypoplastic RV and require both ASD and VSD for viability?
Tricuspid atresia
caused by anterior superior displacement of infundibular septum?
TOF
Most common cause of Early Childhood cyanosis?
TOF
what is the tetrad in TOF?
PROV(pulmonary stenosis(most important cause), RVH (boot shaped heart), Overriding of Aorta & VSD
Improved by squatting
TOF
most common cause of “tet Spells” caused by crying, fever and exercise
Pulmonary stenosis in TOF
what anomaly is seen when pulmonary veins drains into right heart circulation and often associated with ASD & PDA to maintain Cardiac output.
Total anomalous pulmonary venous return
displacement of the tricuspid valve downward into the RV is called? and caused by what drug?
Epstein anomaly & Lithium
Epstein Anomaly is associated with 2 things, what are they?
tricuspid regurgitation & RHF
“ATRIALIZING” the ventricle is associated with what disease?
Epstein Anomaly.
Most common congenital Cardiac Defect?
VSD
Associated with fetal alcohol syndrome?
VSD
Wide fixed split S2 and loud S1
ASD
what is the most common type of ASD
Osmium secundumm defect
Ostium Primum defect is associated with what?
Down syndrome
continous machine like murmur
PDA, AV fistula
what maintains the potency in PDA
low 02, prostaglandin
what is Eisenmenger syndrome
uncorrected left to right shunt, inc pulmonary blood flow, RVH occurs to compensate, shunt bcomes R to L causing clubbing, late cyanosis, polycythemia
Aortic Narrowing near insertion of ductus arterioles and turner syndrome
overriding of the aorta (infantile type)
HTN in upper extremity & weak pulses in lower extremity
Coarctation of aorta (adult type)
intercostal arteries enlarge due to collateral circulation & arteries eroding ribs
coarctation of aorta (adult)
what are the complications of coarctation of aorta
HF, inc risk of cerebral hemorrhage (berry aneurysm),
aortic rupture and endocarditis
what are the heart problems associated with alcohol exposure in utero
VSD, PDA, ASD, TOF
what are the heart problem associated with rubella
PDA, pulmonary artery stenosis, septal defect
Infant of diabetic mother
Transposition of great vessels
margarin syndrome
MVP, thoracic aortic aneurysm, aortic dissection, aortic regurgitation
lithium exposure
Epstein anomaly
Williams syndrom
Supravalvular aortic stenosis
22q11 syndrome
trunks arteriousus TOF