Extras Flashcards
How does the decreased functioning of the electron transport chain lead to oxidative stress?
prematurely and incompletely reduced to give the superoxide radical
How does cytochrome c induce apoptosis?
released into the cytosol, activate a caspase cascade
What is ligation?
the joining of two nucleic acid fragments through the action of an enzyme (or ribozyme - think DNA Ligase)
What is parity?
like chirality - which mirror image is it
What is cerebral microvasculature?
system of tiny blood vessels in the brain
Define neurovegetative
Designating or relating to the autonomic nervous system.
What does thymidine kinase 2 catalyse?
phosphorylation of thymidine
What is the cerebral parenchyma?
The functional tissue of the brain (not the support network)
What is an azide group?
N3-
What does 6-mercaptopurine do?
inhibit purine synthesis, inhibiting DNA synthesis.
What is the tripartite synapse model?
- the functional integration and physical proximity of the synaptic components and their intimate association with surrounding glia
- their combined contributions to activity at the chemical synapse
How does inhibition of dihydrofolate reductase induce apoptosis?
Prevents production of folic acid
What is the autonomic nervous system?
a division of the peripheral nervous system that supplies smooth muscle and glands, and thus influences the function of internal organs.
Acts largely unconsciously.
synaptic components
presynaptic membrane and postsynaptic membrane
