Extrapulmonary manifestations of lobar carcinoma Flashcards
Presentation of recurrent laryngeal palsy
Hoarse voice
Presentation of phrenic nerve palsy
SOB
Which muscle is weakened in phrenic nerve palsy
Diaphragm
Presentations of SVC obstruction
- facial swelling
- difficulty breathing
- dissented veins in neck & upper chest
Pemberton’s sign (emergency)
Raising hands over head —> facial congestion & cyanosis
Sings of Horner’s
- potsis
- amhidrosis
- miosis
What structures are pressed by tumour in the following conditions
- recurrent laryngeal nerve palsy
- phrenic nerve palsy
- SVC obstruction
- Horner’s
- RL nerve
- P nerve
- SVC
- sympathetic glaglion
Presentation of SIADH
Hyponatraemia
Cancer type that releases ectopic ADH in SIADH
Small cell lung cancer
Cancer type that releases ectopic ACTH in Cushing’s syndrome
Small cell lung cancer
Cancer type that releases PTH in hypercalcaemia
SCC
Symptoms of limbic encephalitis
- short-term memory impairment
- hallucinations
- confusion
- seizures
Offending tumour in limbic encephalitis
Small cell lung cancer
Underlying pathology in limbic encephalitis
Immune response against tumour caused by cancer —> inflammation
Antibodies produced in limbic encephalitis
Anti-Hu antibodies
Manifestations if muscle weakness (esp proximal & intraocular) in LEMS
- diplopia
- ptosis (levator muscles)
- slurred speech & dysphagia ( pharyngeal muscles)
Manifestations of autonomic dysfunction in LEMS
- dry mouth
- impotence
- dizziness
A LEMS manifestation best described as synaptic plasticity and characterised by reduced tendon reflexes
Post-tetanic potentiation
Tendon reflexes in PTP following a strong muscle contraction
Temporarily normal
Offending tumour in LEMS
Small cell lung cancer
Channels targeted by Abs in LEMS (& their location)
Voltage-gated Ca channels on presynaptic terminals
