Asthma Flashcards
Asthma is
Chronic inflammatory disease
Is asthma reversible or non reversible
Reversible
Distinguishing characteristics of symptoms found in asthma
- episodic
- diurnal
- atopic conditions
(- bilateral widespread polyphonic wheeze)
Is asthma cough dry or productive
Dry
What stage of a male’s life is a RF for asthma
Prepubescent
1st line diagnostic tests for asthma
- fractional exhaled NO
- spirometry
2nd line diagnostic tests for asthma
- peak flow variability
- direct bronchial challenge with histamine
Preventative meds for asthma
ICS
Example of SABA
Salbutamol
Example of ICS
Beclometasone
Example of LABA
Salmeterol
Example of long acting muscarinic antagonist (LAMA)
Tiotropium
Example of leukotriene receptor antagonists
Montelukast
Why should you be careful with theophylline
Narrow therapeutic window
1st step of asthma Tx
SAB2A + low dose ICS
2nd step of asthma Tx
Oral leukotriene receptor antagonist
3rd step of asthma Tx
LABA inhaler
When do you continue LABA inhaler
If good response
Meds given for MART in 4th step of asthma Tx
4th step (after LABA) Low dose ICS + fast acting LABA
5th & 6th steps of asthma Tx
+++ ICS to med & high dose
what is the 7th step of asthma Tx
- oral theophylline
- inhaled LAMA
MSK indicator of asthma exacerbation
Accessory muscle use
Why is there resp alkalosis in the initial stages of asthma exacerbation
Tachypnoea —> CO2 drop
Why is there resp acidosis in life-threatening asthma exacerbation
T2RF: hypercapnia + hypoxia
PEFR % in moderate asthma
50-75%
PEFR % in severe asthma
33-50%
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RR in severe asthma
> 25
HR in severe asthma
> 110
PEFR in life-threatening asthma
<33%
O2 stats in life-threatening asthma
<92%
Why is the chest silent in life-threatening asthma
No air entry —> no wheeze
HD instability
Why does K+ need to be monitored when on salbutamol to avoid tachycardia
Drug causes K+ absorption into cells
What is given in moderate asthma and in what form
SABA & ipratropium; nebulised
Choice of steroids given in moderate exacerbation
- oral prednisolone
- IV hydrocortisone
3 drugs given in severe asthma
- O2
- aminophilline infusion
- IV salbutamol
When is IV Mg sulphate infusion given
Life-threatening