Bronchial Carcinoma Flashcards
4 most important clinical features of bronchial carcinoma (WICH)
- weight loss
- lymphadenopathy
- clubbing
- haemoptysis
Three types of non-small cell cancer (80%)
- adenocarcinoma
- squamous cell carcinoma
- large cell carcinoma
What is the pathology of small cell lung cancer
Neurosecretory granules —> neuroendocrine hormones —> paraneoplastic syndrome
Apex affected in pancoast tumour
Upper right
Syndrome associated with pancoast tumour
Horner’s
Pathology of mesothelioma
Pleural thickening + distinct plaques
Asbestos is associated with this cancer
Mesothelioma
Latency period in mesothelioma
Huge
Histology findings in mesothelioma
Psammoma bodies
If not palliative, what Tx for mesothelioma MIGHT work
Chemo
Most common lobar carcinoma
Squamous cell carcinoma
Most common RF for SCC
Smoking (asbestos less so)
Histology findings in SCC
Keratin pearls
Mechanism of hypercalcaemia in SCC
- bone destruction —> ectopic PTH analogues
Hypercalcaemia symptoms in SCC
- constipation
- myopathy
- polydipsia
- behavioural changes
Invasion sites of adenocarcinoma
- mediastinal lymph nodes
- pleura
- brain
- bone
Adenocarcinoma common in
- women
- non-smokers
Syndrome associated with adenocarcinoma that causes clubbing and arthritis
Hypertrophic osteoarthopathy
Stain in adenocarcinoma hist slides
Mucin +ve
GI endocrine cells found in histology of small cell lung cancer
Kulchitsky cells
Endocrine symptoms of adenocarcinoma
Gynaecomastia
Main polypeptide released in small cell lung cancer
ACTH
Hormone causing euvolaemic hyponatraemia in small cell lung cancer
ADH
Endocrine presentations of small cell lung cancer
- Addison’s
- Cushing’s
Immunological presentation of small cell lung cancer
LEMS
1st line Ix lung cancer
CXR
Common findings on CXR (pcph)
- peripheral opacity
- collapse
- pleural effusion
- hilar enlargement
Why is CT used
Identify stage and metastasis
When is surgery (1st line) indicated (NSCLC)
- isolated tumour
- single area affected
When can radiotherapy be curative (NSCLC)
Early intervention
Chemotherapy is used as (NSCLC)
Adjuvant
Prognosis of chemo+radio in small cell lung cancer compared to non-small cell
Worse than non-small cell
Endobrachial tx methods for small cell lung cancer
- stents
- debulking
Indication for endobrachial Tx in small cell lung cancer
- palliative
- remove bronchial obstruction