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Y3 Respiratory Conditions > Bronchial Carcinoma > Flashcards

Bronchial Carcinoma Flashcards

1
Q

4 most important clinical features of bronchial carcinoma (WICH)

A
  • weight loss
  • lymphadenopathy
  • clubbing
  • haemoptysis
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2
Q

Three types of non-small cell cancer (80%)

A
  • adenocarcinoma
  • squamous cell carcinoma
  • large cell carcinoma
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3
Q

What is the pathology of small cell lung cancer

A

Neurosecretory granules —> neuroendocrine hormones —> paraneoplastic syndrome

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4
Q

Apex affected in pancoast tumour

A

Upper right

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5
Q

Syndrome associated with pancoast tumour

A

Horner’s

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6
Q

Pathology of mesothelioma

A

Pleural thickening + distinct plaques

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7
Q

Asbestos is associated with this cancer

A

Mesothelioma

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8
Q

Latency period in mesothelioma

A

Huge

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9
Q

Histology findings in mesothelioma

A

Psammoma bodies

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10
Q

If not palliative, what Tx for mesothelioma MIGHT work

A

Chemo

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11
Q

Most common lobar carcinoma

A

Squamous cell carcinoma

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12
Q

Most common RF for SCC

A

Smoking (asbestos less so)

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13
Q

Histology findings in SCC

A

Keratin pearls

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14
Q

Mechanism of hypercalcaemia in SCC

A
  • bone destruction —> ectopic PTH analogues
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15
Q

Hypercalcaemia symptoms in SCC

A
  • constipation
  • myopathy
  • polydipsia
  • behavioural changes
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16
Q

Invasion sites of adenocarcinoma

A
  • mediastinal lymph nodes
  • pleura
  • brain
  • bone
17
Q

Adenocarcinoma common in

A
  • women

- non-smokers

18
Q

Syndrome associated with adenocarcinoma that causes clubbing and arthritis

A

Hypertrophic osteoarthopathy

19
Q

Stain in adenocarcinoma hist slides

A

Mucin +ve

20
Q

GI endocrine cells found in histology of small cell lung cancer

A

Kulchitsky cells

21
Q

Endocrine symptoms of adenocarcinoma

A

Gynaecomastia

22
Q

Main polypeptide released in small cell lung cancer

A

ACTH

23
Q

Hormone causing euvolaemic hyponatraemia in small cell lung cancer

A

ADH

24
Q

Endocrine presentations of small cell lung cancer

A
  • Addison’s

- Cushing’s

25
Q

Immunological presentation of small cell lung cancer

A

LEMS

26
Q

1st line Ix lung cancer

A

CXR

27
Q

Common findings on CXR (pcph)

A
  • peripheral opacity
  • collapse
  • pleural effusion
  • hilar enlargement
28
Q

Why is CT used

A

Identify stage and metastasis

29
Q

When is surgery (1st line) indicated (NSCLC)

A
  • isolated tumour

- single area affected

30
Q

When can radiotherapy be curative (NSCLC)

A

Early intervention

31
Q

Chemotherapy is used as (NSCLC)

A

Adjuvant

32
Q

Prognosis of chemo+radio in small cell lung cancer compared to non-small cell

A

Worse than non-small cell

33
Q

Endobrachial tx methods for small cell lung cancer

A
  • stents

- debulking

34
Q

Indication for endobrachial Tx in small cell lung cancer

A
  • palliative

- remove bronchial obstruction

Y3 Respiratory Conditions (9 decks)

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