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Block 6 > Extracellular Matrix Interactions > Flashcards

Extracellular Matrix Interactions Flashcards

1
Q

This family of proteins recognizes the ECM around cells and tells them if they belong where they are:

A

Integrins

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2
Q

What property of elastin provides its elasticity when a heart beat pumps blood into an elastic blood vessel?

A

Hydrophobicity and relaxed state beta-spirals & cross-linked network conformation.

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3
Q

Elastin cross-links derive from _______ and the aldehydes of lysine produced by lysyl osidase.

A

Lysines

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4
Q

Cross-links of elastin are called ________ and are derived from 4 _________ on up to 4 polypeptide chains.

A

Desmosines

Lysines

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5
Q

Desmosine requires _______ _______ to form.

A

lysyl oxidase

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6
Q

Fibronectin is a glycoprotein, T/F?

A

True

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7
Q

Fibronectin has an affinity for collagen, T/F?

A

True

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8
Q

Does fibronectin have an affinity for itself?

A

Yes

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9
Q

What does fibronectin do?

A

Mediates attachment of connective tissue proteins to each other.

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10
Q

Extracellular fibronectin is closely associated to which intracellular protein?

A

Actin

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11
Q

Does fibronectin bind heparin and heparin sulfate GAGs?

A

Yes

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12
Q

What three proteins/glycoproteins work together to anchor intracellular actin to extracellular collagen? Which one spans the plasma membrane of the cell?

A

Integrin, an adaptor protein (such as talin & vinculin) & fibronectin.
Integrin spans the PM of the cell.

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13
Q

Fibronectin binds to integrin, T/F?

A

True

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14
Q

Does fibronectin mediate ALL ECM attachments?

A

No. Laminin has similar functions

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15
Q

Describe the structure of integrin.

A

It is a dimer, made of two polypeptides: an alpha & beta subunit.

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16
Q

Integrins have a dual role. Describe this.

A

Anchoring ECM to intracellular framework and intracellular signaling.

17
Q

How do the integrins know they are helping the cell attach to the proper ECM components?

A

There are different subgroups of integrins, specific for certain ligands.

18
Q

Are integrins always active and ready to bind ligands in the ECM?

A

No. Extracellular signals can trigger integrin activation.

19
Q

Leukocyte adhesion deficiency is caused by a lack of functional _______ on leukocyte cell surfaces.

A

Integrin

20
Q

Glanzman’s Thrombasthenia is due to a lack of _______ on platelet cell surfaces that makes platelets unable to bind fibrin/collagen to form clots.

A

Integrin

21
Q

In the case of the lamina propria, Type IV collagen binds to _______ , an integrin binding adaptor similar in function to fibronectin.

A

Laminin

22
Q

The porosity (filtering capacity) of the lamina propria can be altered by increasing the number of out of phase (misaligned), stacked sheets of this network protein:

A

Collagen

23
Q

Laminin has a distinct shape. Describe it.

A

Cruciform

Block 6 (19 decks)

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