extra physiology Q's (endterm) Flashcards
What’s the main component of tight junctions?
a. claudin
b. occludin
a. claudin
How does glucose enter the intestinal cells?
a. primary transport
b. secondary transport
c. tertiary transport
d. facilitated diffusion
b. secondary transport
Na driven glucose symports
How does glucose leave intestinal cells and go into the blood?
a. primary transport
b. secondary transport
c. tertiary transport
d. facilitated diffusion
d. facilitated diffusion
Which is found in the basolateral surface?
a. heregulin
b. heregulin receptors
b. heregulin receptors
a= apical surface
What do desmosomes use to anchor cells?
a. actin filaments
b. cytoskeletal filaments
b. cytoskeletal filaments
hemidesmosomes use actin filaments AKA microfilaments
Which connects cells to ECM?
a. anchoring proteins
b. Integrin proteins
b. Integrin proteins
What helps convert integrins from an inactive bent form to an extended primed state?
a. IPP
b. Src
c. Talin
c. talin
Which is a monomer?
a. F-actin
b. G-actin
b. G-actin
Which is added to bound protein to produce microfilaments?
a. F-actin
b. G-actin
a. F-actin
Which is located on cell edges?
a. actin
b. tubulin
c. nucleus
d. myosin I
a. actin
Which is responsible for cell shape and locomotion?
a. actin
b. tubulin
c. nucleus
a. actin
Which is responsible for mitosis?
a. actin
b. tubulin
c. nucleus
b. tubulin
tubulin forms microtubules which are responsible for mitosis
Which of the following is responsible for major cell movement?
a. membrane shuttle movement
b. Integrin shuttle movement
b. Integrin shuttle movement
What stops actin polymerization?
a. cytochalasins
b. phalloidin
a. cytochalasins
phalloidin inhibits depolymerization
Which is NOT a function of myosin I?
a. regulate tension
b. maintain cell shape
c. aid in cell movement
d. bind actin filaments and cellular membranes
e. aid in endo- and exocytosis
c. aid in cell movement
Where do lipids bind myosin I?
a. TH1 domain
b. Motor domain
c. Neck region
a. TH1 domain
Where does ATP bind myosin I?
a. TH1 domain
b. Motor domain
c. Neck region
d. THA domain
b. Motor domain
Which cannot work alone?
a. myosin I
b. myosin II
c. myosin V
c. myosin V
it’s a dimeric motor protein
When does myosin V dissociate from actin?
a. when ATP binds
b. when ADP is released
c. when the phosphate is released
a. when ATP binds
Which initiates the waiting stage of myosin V?
a. when ATP binds
b. when ADP is released
c. when the phosphate is released
c. when the phosphate is released
What protein makes a thick filament?
a. actin
b. myosin
b. myosin
actin = thin filament
Where are the microtubules located?
a. in the nucleus
b. edges of cell
c. in the middle of the cell
c. in the middle of the cell
Which side of microtubules does polymerization take place (which side is the positive side)?
a. α-tubulin
b. β-tubulin
b. β-tubulin
Which of the following microtubules will rapidly dissociate?
a. one with mostly GTP bound tubulin
b. one with mostly GDP bound tubulin
c. one with completely GDP bound tubulin
c. one with completely GDP bound tubulin
it always needs to be active
In mitosis, which microtubule end is facing the microtubule organizing center?
a. α-tubulin
b. β-tubulin
a. α-tubulin
the negative side
In mitosis, which microtubule end is facing the cell edge?
a. α-tubulin
b. β-tubulin
b. β-tubulin
the positive side
Which is responsible for retrograde transport?
a. Kinesin
b. Dynein
b. Dynein
Kinesin & Dynein proteins travel on
a. Microfilaments
b. Microtubules
b. Microtubules
myosin proteins travel on
a. Microfilaments
b. Microtubules
a. Microfilaments
actin microfilaments
Keratin is classifies as a
a. Microfilament
b. Intermediate Filament
c. Microtubule
b. Intermediate Filaments
Flagella and cilia are both made of
a. Microfilaments
b. Microtubules
b. Microtubules
How many polypeptides does it take to produce one Intermediate Filament?
a. 8
b. 10
c. 13
d. 4
a. 8
Desmosomes use what to anchor cells together?
a. Microfilaments
b. Intermediate Filaments
c. Microtubules
b. Intermediate Filaments
aka cytoskeletal filaments
Which of the following is anisotropic to light?
a. A band
b. I band
c. H zone
d. Z disc
a. A band
it’s dark
Which of the following only has myosin?
a. A band
b. I band
c. H zone
d. Z disc
c. H zone
Sarcomere is the area between two ____
a. A bands
b. I bands
c. H zones
d. Z discs
d. Z discs
What attaches actin filaments together?
a. A band
b. I band
c. H zone
d. Z disc
d. Z disc
What causes conformational changes in myosin causing it to bind to actin?
a. ATP hydrolyzed
b. new ATP binds
c. ADP is released
d. Pi is released
d. Pi is released
What allows myosin to release from actin?
a. ATP hydrolyzed
b. new ATP binds
c. ADP is released
d. Pi is released
b. new ATP binds
Which of the following blocks actin from attaching to myosin?
a. Tropomyosin
b. Troponin
a. Tropomyosin
What doesn’t get smaller during a muscle contraction?
a. A band
b. I band
c. H zone
a. A band
the staircase mechanism of muscle contraction is also called
a. Summation
b. Twitch
c. Graded contraction
d. Tetanus
c. Graded contraction
or treppe
What occurs when the load is greater than the tension?
a. Concentric contraction
b. Eccentric contraction
c. Isometric contraction
c. Isometric contraction
What causes Phospholamban Protein (PLB) to open the ER and let the calcium go in?
a. Phosphorylation
b. Dephosphorylation
a. Phosphorylation
Which of the following have vertically arranged myosin filaments?
a. cardiac muscle
b. skeletal muscle
c. smooth muscle
c. smooth muscle
Which of the following causes more smooth muscle contraction?
a. more calmodulin-calcium complex
b. low MLCK to MLCP ratio
c. myosin phosphatase activation
a. more calmodulin-calcium complex
this complex activates MLCK, which activates MLC causing contractions
Which is a source of intracellular calcium?
a. L-type calcium channels
b. Receptor-operated channels
c. Mechanosensitive channels
d. Inositol trisphosphate receptor channels
d. Inositol trisphosphate receptor channels
Which of the following causes depolarization?
a. opening Ca-regulated chloride channels
b. opening potassium channels
c. Na/K-ATPase channels
a. opening Ca-regulated chloride channels
b & c cause repolarization
Which of the following opens by depolarization?
a. receptor operated channels
b. store operates channels
c. L type calcium channels
d. ryanodine receptor channels
c. L type calcium channels
How does Rho-kinase activation lead to muscle contraction?
a. Rho-kinase activates MLCK
b. Rho-kinase activates MLCP
c. Rho-kinase inactivates MLCP
c. Rho-kinase inactivates MLCP (by phosphorylating it)
in VSMC, cAMP & cGMP promote
a. contraction
b. relaxation
b. relaxation
What hydrolysis cAMP & cGMP, thus causing VSMC contraction?
a. Acetylcholine
b. Epinephrine
c. Phosphodiesterases
c. Phosphodiesterases (PDE)
inhibit PDE to relax VSMC
What do cAMP & cGMP do?
a. activate protein-kinases PKA and PKG
b. inactivate protein-kinases PKA and PKG
a. activate protein-kinases PKA and PKG
Which of the following does pars nervosa secrete?
a. Thyroid-stimulating hormone (TSH)
b. Adrenocorticotropic hormone (ACTH)
c. Antidiuretic hormone (ADH)
d. Luteinizing hormone (LH)
c. Antidiuretic hormone (ADH)
ADH and oxytocin = produced in Posterior Pituitary aka pars nervosa
Which of the following is inhibited by dopamine?
a. Thyroid-stimulating hormone (TSH)
b. Adrenocorticotropic hormone (ACTH)
c. Follicle-stimulating hormone (FSH)
d. Luteinizing hormone (LH)
e. Prolactin (PRL)
f. Growth hormone (GH)
e. Prolactin (PRL)
dopamine is also known as prolactin inhibiting hormone
Which of the following works to decrease calcium levels?
a. Parathyroid hormone (PTH)
b. Calcitriol (D3)
c. Calcitonin
c. Calcitonin
What type of cell in islets of Langerhan makes glucagon?
a. α-cells
b. β-cells
a. α-cells
What type of cell in islets of Langerhan makes insulin?
a. α-cells
b. β-cells
b. β-cells
An access of which of the following causes high calcium levels?
a. Calcitriol
b. Calcitonin
a. Calcitriol
What is the relationship between Arterial blood volume & pressure?
a. directly proportional
b. indirectly proportional
a. directly proportional
How does the cross-sectional area of a vessel effect velocity?
a. directly proportional
b. indirectly proportional
b. indirectly proportional
In which of the following is blood velocity higher?
a. capillaries
b. aorta
b. aorta
What reduces the risk of turbulent flow?
a. narrowed vessels
b. higher velocity
c. higher viscosity
d. anemia
c. higher viscosity
What has the highest volume of blood?
a. arteries
b. veins
b. veins
more compliant