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Crrab 1 > Extra micro > Flashcards

Extra micro Flashcards

1
Q

What are some virulence factors of strep viridans?

A 
Alpha hemolytic 
Bile resistant
Optochin resistant (can live close to the chin) 
Gram + 
Adheres to fibrin platelet aggregates
Forms dextrans
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2
Q

What are some virulence factors of staph epidermidis?

A

Gram +
Catalase +
Urase +
Coagulase -
Novobiocin sensitive
Normal flora that contaminates blood cultures
Infects prothetics by producing adherent biofilms

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3
Q

What is the most common bacteria causing intravascular catheter infections? Sx’s?

A

S. Aureus due to biofilm production

chills, fevers, Tenderness, purulent discharge and swelling

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4
Q

What is the timeline for infectious agents for prothetics valve placement infections?

A

Up to 1 year= Staph epidermidis 50% ad 20% staph Aureus

After 1 year= Strep Virdans

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5
Q

What about the timeline for pacemaker and defibrillator infectious agents? Sx’s?

A

Up to 2 weeks= S Aureus
2weeks to 1 year= S Epidermidis
after 1 year= Strep Viridans

Fevers chills bacteremia as well as swelling, erythema and pain at implant site

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6
Q

If you have endocarditis sx’s but negative cultures what is the most likely cause?

A

Coxiella burnetii
HACEK
Bartonella spp

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7
Q

What is significant about Coxiella burnetii on hx?

A

If you have parrots as pets

+ IgG Ab and on cultures

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8
Q

What are the virulence factors of HACEK organisms?

A

Must use blood argar
Fastidious gram - bacteria
Normal human biome– around mouth

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9
Q

What criteria of Jones needs to be met for Dx? What does it dx/

A

Rheumatic Fever

  1. 2 major and strep A infection evidence
  2. 1 major and 2 minor and strep A infection evidence
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10
Q

What are the major Jones criteria?

A 
J- Joints--> migrating polyarthrits 
O- Heart problems (panscarditis) 
N- Nodules Subcue 
E- Erythema Marginatum
S- Sydenham's Chorea
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11
Q

What are the minor Jones criteria?

A
  • Fever
  • Arthralgia
  • Increase CRP and ESR
  • Prolong PR interval
  • Previous rheumatic HD or rheumatic Fever
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12
Q

What is needed for evidence of prior Strep A infection?

A

Elevated ASO

Anti-DNase B titers

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13
Q

What is ASO?

A

Anti-streptolysin O

- Oxygen labile streptococcal hemolytic exotoxin

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14
Q

What are Janeway lesions and their cause?

A

Arterial emboli

  • NON-tender hemorrhagic lesions on palms and soles
  • Bacteria found in lesion
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15
Q

What are the immunologic phenomena that meet Dukes criteria?

A

Rheumatoid factor
Roth’s spots
Osler’s nodes

Type III hypersensitivity

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16
Q

What are Osler’s nodes?

A

red purple slightly raised lumps on the pads of fingers and toes

17
Q

What are some virulence factors of strep viridans?

A
  • Dextran production/Glycocalyx formation

- surface adhesion proteins (FimA, GspB)

18
Q

What are some virulence factors of Strep pneumonia?

A

capsules

19
Q

What are some virulence factors of strep pyogenes?

A

Capsule

M protein

20
Q

What are some virulence factors of neisseria meningitidis?

A

Capsule

21
Q

What are some virulence factors of Enterococcus species?

A

Biofilm formation

22
Q

What are some virulence factors of Staph Aureus?

A
  • Capsule
  • Biofilm formation
  • Elastin, Collagen, Fibronetin (FnbpA) binding proteins
  • Coagulase
  • Leukocidin
23
Q

What are some virulence factors of staph epidermidis?

A
  • Sd repeat containing protein- G (SdrG)

- Biofilm formation (various proteins)

24
Q

What are some virulence factors of Coxsackie A and B, Adenovirus?

A

Coxsackie-Adenovirus cellular receptor (CAR) binding proteins

25
Q

What are some virulence factors of rickettsia rickettsia?

A
  • OmpA and OmpB (attachment)

- Type 4 secretion system (T4SS) host cell entry

26
Q

What do strep and staph use for attachment?

A

MSCRAMMs

- Microbial surface components recognizing adhesive matrix molecules

Crrab 1 (27 decks)

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