EXTRA Flashcards
SE Linezolid
Inhibit MAO-A/B so Serotonine syndromein combination with SSRI’s
Thrombocytopenia
Metronidazole SE
Disulfiram like reaction with alcohol
Metalic taste
רכבת זה דבר שמרגישים בו מסוחררים פלוס זה פשוט גוש של מתכת
Mertonidazole MOA
Makes free radicals which interfears with nucleic acid production
Fidaxomycin MOA
Inhibits RNA pol
C. difficile
Fidaxo for diFFFFicile
Rifaximin
Derivative of Rifampicin
RNA pol
For IBS
For hepatic encephalopathy
זה פשוט יושב במעיים אז כמעט ללא תופעות לוואי
Metronidazole in case of H.Pylori
PPI
Amoxicillin / Metro
Clarythromycin
Nitrofurantoin- Everything
נכנס מהר לשתן אז אין לו אפקט סיסטמתי
לא לפרוטאוס ולא לפסאודומונאס!! הם חמורים יותר
urine acidity enhance activity
Fosfomycin- Everything
Inhibits synthesis of NAG- cell wall (enolpyruvate transferase)
For uncomplicated UTI
GI SE
Direct Thrombin inhibitors
Dabigatran
Bivalirudin
Reversible agent fot Heparin
Protamine
Management of acute bleeding in patients with Hemophilia
Aminocaproic acid
Inhibits plasminogen activation
Myeloid growth factor
Filgrastim stimulate G-CSF
Dopamine D2-R agonist
Bromocriptine
Busipron indication
5HT1A partial agonist
General anxiety
Management of status epalipticus
Lorazepam/Midazolam
Phenytoin/Leveteracetam
RA pharmacology
Acute: NSAID’s
Disease Modifying: Methotrexate
IBD pharmacology
Mild: 5-ASA
Moderate: Glucoroticosteroids, 6-MP
Immunotherapy- Fusion and Ab and MOA
Rituximab- anti CD20. reduce B. Ritux reduce B
Infliximab, Adalimumab- Anti TNFa
Toclizumab- Anti IL6. T+B
Ustekinumab- Anti IL12. inhib TH1
Natalizumab- Inhibit T cell anti integrin נטטטלי
Dupilumab- Anti IL4 די זה האות הרביעית
Abatacept- Fusion protein inhib. CD28 on T cell. אבא תצא! הפיוזון הזה לא טוב לך. אבטצפת הכי לא קשור
Infliximab, Adalimumab- MOA
Anti TNFa
Inhib. of Cytokine gene expression indications
Mostly before bone marrow transp.
Opioids- analgesia
Hydromorphone- strong. analgesia
Fentanyl- strong. analgeisa and anesthetica
Tramadol- weak. analgesia. also inhibits 5HT reuptake
Merphidine- strong. analgesia
Oxycodone- analgesic
Opioids- שלשול
Loperamide, Diphenoxylate
התמכרות וחוט שדרה
Methadone, Buprenorphine
Nalbuphine
Dont give Valproate with
Thiazides and NSAID’s
They decrese the clearance
Anti epileptic which are not broad spectrum
Phenytoin- Inhib. of axonal NaCh
Carbamazapine- -“-
Vigabatrin- Inhibits GABA metab.
Phenobarbital- GABA NaCh open longer
Very Privet Cards Play
Privet bcs it is narrow spectrum
Give Cidofovir with
Probenecid
5th gene cephalo
Ceftolozane+tazobactam
Ceftarolin-fosamil
Acetazolamide indications
Diuretic only if also metabolic alkalosis Glaucoma Mountain sickness Epilepsy Meiners disease
Thiazide diuretics
Hydrochlorothiazide
Indapamide
Thiazides MOA
Na/Cl inhib
Thiazides SE
Hyper GLUC Glycemic Lipidemic Uricemic Calcemic
ADH antag.
Tolvaptan
For SIADH
CCB and other vasodilators
Amlodipine, Nifedipine, Nimodipine, Felodipine Hydralazine release NO Bosenta inhibits Endothelin Sildenafil inhibits PDE5 Verapamil