C: 1-4

Question 1

Disinfection vs Sterilization

Answer 1

Disinfection; reduce amount of potential pathogenes
Sterilization: Removal. complete elimination

Disinfectant is on non living surface
Antidecptic on living surface

Question 2

חומרים לאנטיספטיקה וכו

Answer 2

Ethanol+isopropanol: Denature proteins השני יותר אפקטיבי אבל גם יותר מסוכן
Povidone iodine is Halogen: on skin
H2O2: Mouth wash, wounds
Chlorhexidone: Hospital scrub rutine. Ototoxicity!!
Octenidin
Invert soaps

Question 3

TB drugs and CYP450

Answer 3

IIIIsoniazid inhibits

Rifampin enhances

Question 4

RIPE SE

Answer 4

זה חרא של מחלה אז התרופות סופר חזקות! חרא לכבד
hepatotoxicity

Rifampin- orange! nephro
Isoniazid- B6 defici. –> neuropathy, lupus, G6PD, metabolic acidosis
Pyrazinamide- dont give in pregnancy
Ethambutol- visual. E for Eye

Question 5

More mycobacteria drugs

Answer 5

Streotomycin
Kanamycin

Cycloserine D-ala…

Question 6

Leprosy Tx.
MOA
SE

Answer 6

Dapsone
Inhibit folic acid synthesis
Can also be given to AIDS pneumonia

G6PD
Methemoglobinemia

Question 7

Acyclovir/val-
MOA
Usage
SE

Answer 7

Guanine analog
Lacks -OH group at 3' end
Monophosph. by viral enzyme
Acyc- HSV
Val- VZV V for V

Nephro and CNS

Question 8

Gancyclovir
MOA
Usage
SE

Answer 8

Guanosine. 3Xphosp. by Kinase (UL97)
CMV

Bone marrow

Question 9

Cidofovir
MOA
Usage
SE

Answer 9

Cytidine analog
CMV, HSV, HPV
CCCC

Nephro. Give with probenecid

Question 10

Foscernat
MOA
Usage
SE

Answer 10

DNA/RNA pol inhib.
CMV for Gancyclovir resistant

Nephro and CNS

Question 11

Pneumocyctic jirovecy tx.

Answer 11

Foscernat with Pentamidine

Question 12

Influenza drug
MOA
Usage
SE

Answer 12

Oseltamivire
Neuroamenidase inhib.

GI

Question 13

Anti RSV

Answer 13

Palivizumab- Anti fusion protein

Ribavirin- Like Guanisine. Can cause hemolytic anemia

Question 14

General info on Direct acting antivirals

Answer 14

2-3 agents for 12-16 weeks for Hep. C

Question 15

DAA

Answer 15

Protease inhib: Paritaprevir, Grazoprevir
Nucleoside polym. inhib: Sofosbuvir
NNPI: Dasabuvir
NS5A ibhib: Velpatsavir, Elbasavir

Question 16

Traditional hepatitis Tx.

Answer 16

INFa- JAK STAT. Pegylated. CNS, Flu, Lupus
Entacavir- Guanosine analog
Tenofovir- Nucleotide. Nephrotoxicity

Question 17

Malaria drugs

Answer 17

Chloroquine
Mefloquine is prophylaxis. vivid dreams
Quinine and Artesunate for severe infections
Lumefantrine causes QT prolongation
Atovaquone/Proguanil
Primaquinetreats liver phase of vivax/ovale and causes hemolysis in G6PD

Question 18

Parazites and Helminths drugs

Answer 18

Metronidazole for parazites
Rest for helminths
Mebendazole inhibit microtubule and is teratogenic
Ivermactin (GABA)
Niclosamide is oxidative phosph. for Taenia

Question 19

Antifungi

Answer 19

Ampho.B and Nystatin interacts with Ergosterol cause hypotension, Phlebitis, nephro, CNS
Azoles inhibit Ergosterol synthesis

Question 20

Azole

Answer 20

C-FIV

Clotrimazole- topical! clothing is on top!
Fluconazole- BBB! meningitis…
Itraconazole- for dimorphic
Voriconazole- aspergillus. vortex! visual bad!!

Question 21

More antifungi

Answer 21

Flucytosine –> 5FU inhibit Thymedilate synthase. give in meningitis with Ampho.B
Capsofungin- for cell wall. Candida.
Terbinafine- inhibits Squelane epoxidase. topical. for onychomycosis

Question 22

Anti HIV drugs

NRTI

Answer 22

Ziduvodine
Lamivudine
Abacavir
Tenofovir

Question 23

Which NRTI is the most toxic and why?

Answer 23

Ziduvodine

Bone marrow suppression

Question 24

NNRTI

Answer 24

Etravirine
אתרע מזלו לא להיות NRTI

Do not require activation via phosphorylation

Question 25

Protease inhibitors

Answer 25

Ritonavir
Darunavir
Lopinavir

Question 26

Integrase inhib

Answer 26

Elvitegravir

Elvis is not integrated

Question 27

Fusion inhibitors

Answer 27

Maraviroc

Question 28

Tx regiemen for HIV

Answer 28

2+1 role

Tenofovir, Emtricitabine, Ritonavir