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Pharma final > C: 14-17 > Flashcards

C: 14-17 Flashcards

1
Q

Quinolone

Fluroquinolone

A

2nd gene: Norfloxacin, ciprofloxacin (pseudomonas), ofloxacin
QuinolCON LM!
3rd gene: Levofloxacin. for monaLiza (Pseudomonas)
4th: Moxifloxacin

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2
Q

Quinolone
Fluroquinolone

MOA

A

Inhiibit Topo 2
תחשבי על מלכה עם שתי צמות כאלו יפות מסביב לראש
Mainly G- and UTI
מונה ליזה בהריון עם רגליים נפוחות SE cartilage and teratogenic
QT prolonged

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3
Q

What is quinolone?

A

1st gene fluoro

Nalidixic acid

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4
Q

Special indication 2nd gene

A

2nd line of therapy fot TB

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5
Q

ciprofloxacin

A

Topical otitis externa

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6
Q

Aminoglycosides MOA

A

inhibit 30S

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7
Q

Macrolides

Ketolides

A

Clarithromycin
Erythromycin/Roxythromycin
Azithromycin
Telythromycin- people on keto want to tell you about it

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8
Q

Telythromycin

A

Give for mcrolides resistant pneumonia

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9
Q

Macrolides
Ketolides

MOA

A

Bind 50S
from P site to A site
Stops CYP450
QT prolongation

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10
Q

Clindamycin
Streptogramin
Oxalidinone

A

Clindamycin
Streptogramin: Quinupristin, Dalfopristin
Oxalidinone: Linezolid

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11
Q

Clindamycin

A 
Clean all the extra weight!
50 S gym
Anaerobic!
Staph, Strep, MRSA
GU/GI
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12
Q

Streptogramin

A

Quinupristin, Dalfopristin
block exit at 50S
איזה מלכה מי שמרימה 50 קילו! מלכה שקוראים לה דלפי

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13
Q

Linezolid

A

Inhibit initiation complex on 50S
MRSA, VRE
Dont give with SSRI’s
Inhibitor of MAO-A/B

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14
Q

Linezolid inhibit

A

MAO-A/B

They put a line on MAO

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15
Q

Glycopeptides

MOA

A

Teicoplanin
Oritavacin
Vancomycin

Bind at D-ala D-ala. Interferes with cross linking
גלייקופפטיידס זה טוב! TOV

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16
Q

Lipopeptides

A

Daptomycin
Depol of the cells membrane
MRSA
VRE

17
Q

Fusidans

A

Fusidic adis
EF-G inhibition
Cellulitis and impetigo

18
Q

Bacitracin

A

Interfers with membrane carrier molecules that transport the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane

19
Q

Bacitracin SE

A

Nephrotoxicity so give topical

20
Q

Muripocin

A

Topical

Inhibit tRNA synthetase

Pharma final (24 decks)

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