A: 25-28 Flashcards
Benzo’s MOA
Increase affinity of endogenous GABA to GABA-R
Increase frequency of Cl- Ch. opening
Benzos and DOA
super MaN is super fast DC movies are super long A is in the middle of mAn Midazolam, Nitrazepam Alprazolam Diazepam, Clonazepam
Diazepam indicationns
Anesthetic Sedation Muscle relaxant Panic Withdrawal
Clonazepam indic.
Bipolar
Seizures
Benzo’s drug interaction
Antihistamines gen 1
Alcohol
Barb’s
…
Benzo’s antag.
Flumazenil
Non Benzo’s
Zaleplon, Zolpidem- GABA-A agonist
Your BMR is up when you sleep well
Busiprone- 5HT partial agonist. Busi is prone to allergies
Melatonin-
Rameltone- Melatonine agonist. ram sleeps and dream on Elton
1st gene antipsych. and SE
Also MOA
CHF is a chronic old Disease (CHFD)
Chlorpromazine- low potency! Corneal deposits
Haloperidol- Neuroleptic malignant Synd.
Droperidol
Flupentixol- wheb you have FLU you PENT IX on ALL
Promise me there is no Chlor!
Halo! Drop to the Floor
All block D2-R
1st gene antipsych. SE
Tardive dyskinesia Hyperprolactinemia Weight gain Autonomic Thermo
Primary indication for antipsych.
Schizofrenia
1st gene antipsych. are for positive or negative symp?
Positive
2nd gene antipsych.
Quiet pls! Only Whispering is Appropriate
Quetiapine and Clozapine. CLOZAP! Quit tipping
Olnazapine- CLOZ the door with your OLNA
Risperidone- RiIS got married to mathew PERI and now they are DONE
Aripiprazole- ARI PIPed to RAZ
**Cariprazine
2nd gene antipsych. dominant MOA
5-HT blockade
Benzo’s indication
Status epilepticus
Psychosis
Sleep problems
Not for major depression
Antagonism for Benzo’s
Flumazenil
Depot injection
Injection formulation of a medication which releases slowly over time
Antipsychotics antag D2-R MOA
D2-R are Gi coupled
So if we inhibit –> Increased cAMP (Bcs usually if Gi is active the cAMP will decrease)
Increased cAMP cases NF on the Dopamine release
D2-R are where?
Mesolimbic system
Striatal Frontal System
1st gene Antipsych. SE
Extra Pyramidal
ADAPT
Acute Dystonia, Acathesia, Parkinsonism, Tyrid diskinesia
