Exsudative inflammation Flashcards
role of exsudative inflamamtion
- dilute causative agent
- bring cells and mediattors to damaged tissye for healing
criteria of classification
- according to character(type) of inflammatory exsudate:serous, fibrinos, pururlent, gangrenous
- accoridgn to localization
a). superficial: mcosa, serous
membranes(pleura, pericardium, peritoneum, synovia), skin
mucosal surfaces, luminous organsa+cavities covered by mucosa
b) profound(interstitial)
whcihc types of exsudate heal without defect(no tissue loss)
serous(catharall) and lymphoplasmacytic(non-purulent) which is a subtype
which exsudate heal with defect
fibrinous, purulent(purulent catar/abscess/phlegmona), gangrenous(putrescent)
what is typical for serous inflmation
- in mucosa: open dilated vvesles, hyperemic, increased leukocytes inside them (leuckostasis)
-submucosa: see fluid–>swelling–>edema, inflmmatory infiltrate–>traveling upper part, low inflammatory cells
-epi: preserved, goblet, serous glnads stimulated to produce mucin–>mucin+edema–>seromucinous exsudate on surface of mucosa
FLUID +PROD OF FLUID WIHT EXSUDATION WITH LOW PROPORTION OF PROTEIN AND LOW NR OF INFLAMMATORY CELLS, EPI IS PRESERVED
purulent(suppurative )inflammation
^nr of leukocytes-neutrophil infiltarte–>traveling thorugh epi–>surface–>mixed with mucin–>mucopurulent exsudate=PUS(destroy tissue by epitheium–>spred of cells thorugh
PUS : dead neutrophils and tissue detritus
- yellow/green color
-viral infection then bacterial superinfeciton
fibrinous inflammation/psudomembranous
submucoasa: vascular chnages, edema, infiltarte, cell are low nr
mucosa: destroyed, on surface:leaking fibrillar proteinous eosinophilic material+destroyed cells+inflmmatory cells+erythrocytes–>fibrin act as glue–>pseudomembrane
- may be seen in diptheria:
necrotizinf brinchitis (pseudomembranoys necrotizing) Gnagrenous inflammation
- secondarly chnagesd necrosis
- necroiss: damage deeoer parts like submucosa
- developing lesions, ulcers with are covered by pseudomembranes at the bottom
-around edema, neutrophils
-antibiotics
nectrotic tissue:infiltarted by exsudate with fibrin
serous inflammation:
superficial
1: mucosa: catharral inflammation
- serous membranes: serous, serofibrinous, serohemorrhagic
- skin: blisters (vesicle)
serous infkammation: interstitila
- only early stage
- skin: urticaria-inflammatory edema of skin interstitum
- allergic reaction
-
outcomes of serous inflammaiton
- healing without defecet, regenration of mucosa
- transformation (progression) into another type of exsudative infallamtion, often into PURULENT
- tranformation into chronicity
difference btw serous and lymphoplasmacytic inflammation
lymphoplasmacytic has marked cell proliferation and we typically find it in viral infections and immunopathological processes
lymphoplasmacytic (non purulent) inflammation:superficial
- mucosa: infleunza
- viral infectiom - serous membranes:lymphocytic meningitis
- skin: chronic dermatoses
-inflammaton of skin as hypersensitivity
lymphoplasmacytic (non purulent) inflammation: interstitial
- myocardium: viral myocarditis-coxackia B
- salivary glnds: epidemic parotitis (mumps), autoimmune siaoadentitia(sjogrens)
- lungs: interstital pneumonias, lung fibroses
- transplantatiom immunity: GvHD
fibrinous inflammation: superficial
1: serous membranes
a) dry form(fibrinous): only fibrin
b)humid form(sero-fibrinous): fibrin +H20
2: mucoses and skin
a)Croupous: croupus pneumonia
- fibrotization(carnification)
- fibrin not strongly anchored–>undergo organixation–>fibrotization
-looks like meat
b) diphteric(diphteroid)
- real pseudomembranous
-diphteria, dysentery, pseudomembranous colitis
-exfolation of pseudomembrane-reepithelization+ productive inflammation with fibrotisation
c) Escharotic: influenxa tracheitis, hemorrhagic cystitis, buring healing with defect-scar strictures
- worst tupe
-highest grade of damage:
- like burning–>scar
