bone tumors-biposy diagnosus-practical

Question 1

boen forming; being and malignant

Answer 1

bening: osteoma, osteroid osteoma, osteblastoma

malingnat: primary and secondary osteosarcoma

Question 2

cartilagginous forming: b and m

Answer 2

being; osteochondroma and enchondroma

m: chondrosarcoma

Question 3

miscellaneous forming

Answer 3

giant cell tumor(usually beingn)
erwing sarcoma (medulla)

Question 4

location of bone tumors

Answer 4

Diaphysis: osteoid osteoma (cortex), fibrosarcoma, ewing sarcoma, bone cyst, enchondroma

Metaphysis: osteosarcoma, chondrobalstmona, aneurysmal bone cyst

Epiphysis: chondrobalstoma

Question 5

osteoma

Answer 5

• new piece of bone growing on another-skull
• being tumors
• homoplastic osteoma(heteroplast osteomagrowe on other TISSUE))
  -Uncertain: maybe by embryonic, taumatic or infection
• see in Gardners syndorme

Question 6

osteoid osteoma

Answer 6

• benign
  -often in leg, spine(painful scolialis)
• teenagers or young afults, males
• produciton of excess bone and secrete paincauseing prostaglandings–>pain at night
• may spontaboulsy resolve

Question 7

osteoblastoma

Answer 7

-bening, larger than osteoid osteoma
-medulla-VC and spinoys processes, ribs, ilium, long bones, absence of reactive bone formaiton,
-young indiviudals, 10-30y
- centrala rea-nidus: mineralixed, sclerotic or calcified, rim of scleroti cbone at edges
- may spontant regress

Question 8

Osteosarcoma

Answer 8

-primary malignant
-primitive bone forming mesenchyma
-most comon of malignant bone neoplasm-35%
-metapysela region of tubular long bone, 50% aroundknee, hip, shoulder, facial bone

• solid, hard, irrehular
• rises periosteum away from the bone and form Codmans triangle, surronding tissue are infiltarted
• cells are pleopmorphic(anaplastic), some ginat, nr atypical mitoses
• pathological osteoid matric
  -surgery, amptutation, chemo, radiation

Question 9

chondroma

Answer 9

-bening cartilaginous, encapsulated with lobular growing patern
- vascular axes in tumor
Location
- enchodroma: in bone and expand it, solitary or multiple, metaphysreal location inf short
-periosteal chondorma: on bone surface beneath periosteum

Morpholgy:
1, central necorsis and dystrophic calcification, lobular seperaed bby firbovascular storma
2. affected cells: congdrocytes and cartilagionus cels–>

Question 10

chondrosarcoma

Answer 10

-malignant
-cartilage based tumor
-25% of primary bone vcancer aka second most commen
- older people
-from chondroblasts
- MTS to lung and skeleton

Question 11

giant cell tumor(osteoclastoma)

Answer 11

-end of long bones in knee region, also wrist, arm, pelvis
- feamle, 20-40y
-mostly bening
-MTS–>lungs

Question 12

ewing sarcom

Answer 12

-malignant, small, blue, round cell tumor
- pelvis, femur, humerus, ribs
-common genetic locus responsible for ewing saercoma and primitive neuroectodermal tumors
-male teenagers
-characteristic of both mesodermal and ectodermal origin

Question 13

aneurysmal bone cuts

Answer 13

-second-third deaced
-trauma
- lesions of surface of bone and also in metaphysis and epiphysis
- leasions with inetrnal sepate and longitudinal striations
- ABC micrscopically: cystsic spaces with blood, fibrous septa have immature woven bone trabeucula as well as macrophges filled with hemosidern, fibroblast , cappilaries and giant cells