Exotics 1 Flashcards

1
Q

What are 6 differences between reptile and mammal eyes

A
- Straited muscles of the iris, not smooth 
○ Conscious control over pupil size 
○ Need to use different drugs 
- Cartilaginous septum between eyes 
- Conus papillaris 
- Pupil shape variations 
- Parietal eye 
- Harderian gland (in all reptiles)
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2
Q

Lizard eyes what are the 2 different structures can have, function and 2 other structures in the eye

A
  1. The spectacle (eye cap, skin or scale that covers the eyes - fused eyelids) in most geckos
    § Sheds with the skin - important
    § Protects the cornea
  2. Upper eyelids immobile and short, lower eyelids close the eye (in those that have eyelids)
    - Rigid third eyelid
    - Scleral ossicles
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3
Q

Snake eye what structure present, function, shedding, is there a lacrimal gland

A
  • Spectacle
    ○ The glands excrete into the space between the cornea and the spectacle and fluid drains down through nasolacrimal ducts
    ○ It becomes cloudy just before ecdysis (shedding of the skin in reptiles) (Harderian gland)
  • no lacrimal glands - don’t need as have a spectacle
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4
Q

What are 9 important environmental considerations for skin in reptiles

A
  1. Sharp or abrasive furnishings and substrates
  2. Water quality
  3. Humidity
  4. Companions
  5. UVB
  6. Mites
  7. Escape attempts
  8. Hygiene
  9. Biosecurity
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5
Q

List 8 specific clinical signs for eye issues in reptiles

A
  1. Swelling of eyelids
  2. Blepharitis
  3. Conjunctivitis
  4. Ocular discharges
  5. Discolouration of globe
  6. Epiphora
  7. Nasal discharge
  8. Eyelids can’t open - may need to bathe in warm water - DO NOT FORCE OPEN
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6
Q

List 6 non-specific clinical signs for eye issues in reptiles

A
  1. Light sensitive
  2. Rubbing at face
  3. Can’t target food items
  4. Reluctant to eat
  5. Reluctant to move
  6. Hiding
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7
Q

List 9 causes for swelling of reptile eyelids

A
  1. Hypovitaminosis A in chelonians
    ○ Hyperkeratosis, swollen eyes, digestive issues
  2. Blepharitis and conjunctivitis
    ○ Usually hygiene and foreign body related
  3. Foreign material/trauma
  4. Viral (pox/herpes)
  5. Bacterial (primary/secondary to sepsis)
  6. Periocular masses
    ○ Unilateral
  7. Neoplasia
  8. parasitic
  9. caseous abscess formation (tend to be harder than mammalian)
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8
Q

What are 6 main causes of ocular discharge

A
  1. Dacryocystitis
  2. Hypovitaminosis A
  3. Bacterial conjunctivitis
  4. Foreign bodies - common
  5. Epiphora due to blocked duct or irritated conjunctiva
  6. Corneal ulceration - IF DON’T HAVE A SPECTACLE
    ○ Stain with fluorescein
    ○ Infection
    ○ Trauma
    ○ Lipid deposits
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9
Q

What are 6 main issues that can arise of the spectacle

A
  1. Opacity prior to ecdysis (shedding)
  2. Retained spectacle due to dysecdysis (when haven’t shed properly -> lack of humidity or lack of abrasive items to rub against)
  3. Bullous spectaculopathy -> accumulation of clear fluid in Subspectacular space that presents as a bulging of spectacle
    ○ Aspirate to determine the cause but give pain relief as well
  4. Subspectacular abscess
  5. Retrobulbar abscess
  6. Trauma
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10
Q

What are 5 main opthalmic disorders of reptiles and 5 main systemic diseases that can lead to this

A
Other ophthalmic disorders 
1. Uveitis 
2. Hypopyon 
3. Cataracts
4. Glaucoma difficult to determine 
5. Anopthalmus/micropt halmus
Systemic diseases contributing to ophthalmic pathology 
1. Stomatitis - inflammation in the mouth 
2. Rhinitis - respiratory disease 
3. Malnutrition
4. Septicaemia 
5. Any diseases causing dehydration or reduced healing
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11
Q

What is important to consider with reptile eye/skin treatment and list 7 general things to do

A
  • Be gentle, need to be in optimal temperature to heal
    1. Topical - Wet swabs over the surface of the eyes
    2. Surgical
    3. Systemic
    4. Flushing
    5. Warm wet compresses to open eyelids
    6. Soaking/bathing/humidity increase -> for retained spectacles
    7. Husbandry can always be improved
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12
Q

What is turtle shell made of and what important to remember and reptile connective tissue how much elastin

A
  • Osteoderm/dermal bone - in turtles
    ○ Shell -> active live skin with bone -> DON’T DRILL THE BONE
  • Connective tissue (variable elastin)
    ○ Scales aren’t very elastic but the skin between the scales are
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13
Q

Reptile skin anatomy what are 7 important factors/structures/functions

A
  1. Barrier to abrasion, desiccation, UV, damage, impermeable to pathogens
  2. Variable water permeability - generally better than mammals
  3. Glands - scent, lipid
  4. Locomotion - gastropeds -> the scales on the dorsum that help to move in snakes
  5. Horns, bristles - sensory and defense
  6. heat sensing pits
  7. Mite pockets
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14
Q

ecdysis what is it, how works, what is important while occuring

A
  • New layer grows under old ones
  • Inner layer of old skin dissolved and lymph infiltrates to separate the old from the new
  • More sensitive to toxins and damage while shedding
  • Spectacle needs to shed at the same time
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15
Q

What are 14 important things to ask for with history for reptiles

A
  1. Temperature
  2. Relative humidity
  3. Substrate - too wet or abrasive
  4. Furnishings
  5. Burrows
  6. Hygiene
  7. Water quality
  8. Filtration - ventilation equivalent for aquariums
  9. UV type and strength
  10. New introductions
  11. Visits by friends
  12. Feeding of live prey
  13. Diet
    Supplements
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16
Q

What is important to consider with feeding of live prey and what clinical signs can you see with turtles

A
  • if sick or don’t want to eat the live prey can eat the predator
    • Even with turtles -> feeder fish too big for turtle -> generally lose toes in this case
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17
Q

What are the 4 main types of clinical signs for reptile skin disorders

A
  1. Degenerative (ulcers, slipping skin, fissures, thinning)
  2. Proliferative (papillomatous, hyperkeratotic, neoplastic)
  3. Colour and textural changes
  4. Writhing, skin, rubbing, scratching, bathing, basking
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18
Q

What is involved with the examination and diagnosis of skin conditions in reptiles

A
  1. History before handling
    ○ Trying to push through vents, basking more or less, sitting in water bowl for snakes -> might have mites
  2. Examine from a distance
    - Pruritis, eyes closed limbs abducted, breathing noises
  3. Photographic documentation and magnification
  4. Periphery of tails, digits, scutes
  5. Wet swabs and smear
  6. Scrape, aspirate, culture, biopsy
  7. Blood tests, xrays
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19
Q

What are 7 common non-infectious skin conditions of reptiles

A
1. Trauma 
○ Bites (prey/companion)
○ Substrate/furniture 
○ Abrasions
○ Escape attempts 
○ Baytril injections -> dilution as can cause ulcers
§ Not the only antibiotics 
2. Burns - heat/chemical 
3. Neoplasia 
4. Diet 
○ Ca/vitD/UVB/Temp
○ hyperVit D
○ Gout 
5. Water quality 
6. Blisters/bullae
○ Excessive humidity 
○ Wet substrate 
7. Excessive UV exposure
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20
Q

What are 7 common skin infectious conditions

A
1. Abscesses 
○ Fibrous and caseous - hard 
○ Mycobacterium
○ Opportunists 
2. Dermatitis (scale rot) 
○ Bacterial, fungal, ectoparasitic 
3. Viral 
4. Ulcerative 
○ Bacterial/fungal 
5. Sepsis resulting in skin lesions 
6. Cellulitis/sinuses 
7. Extension of stomatitis 
○ Common in lizards and turtles 
○ LOOK IN THE MOUTH
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21
Q

What are 5 common skin conditions of pythons

A
1. Mites 
○ Ophinoyssus natricis 
2. Trauma 
○ Burns, bites from prey, escape attempts, co-feeding, handling 
3. Scale rot 
○ Ventral dermatitis 
4. Blister disease 
○ Humidity too high/wet substrate 
○ Burns 
○ Migrating nematodes 
5. Dysecdysis 
○ Systemic disease 
○ Vivarium set up 
○ Overhandling
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22
Q

What are the 6 main common skin conditions of lizards

A
1. Trauma 
○ Bites/burns 
2. Dermatitis secondary to poor husbandry 
3. Dysecdysis 
○ Humidity too low
○ Systemic disease, scars 
4. Ticks 
5. Malnutrition 
○ Vitamin D deficiency 
6. Fungal infections 
○ Yellow fungal infection - crysosporium anamorph of nanizziopsis varesii (CANV)
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23
Q

What are the 4 main skin conditions of turtles

A
1. Shell rot 
○ Water quality/diet/UV
2. Oedema 
3. Scale and carapace deformities 
○ Malnutrition/injuries 
4. Trauma 
○ Co-inhabitants 
○ Tank design 
○ Gardening injuries
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24
Q

What are the 4 main areas of treatment for reptile skin and examples within

A
  1. Surgical
    ○ Excise, debride or repair lesion if possible
    ○ Epoxy resin/wires/plates/ for dermal bone
  2. Systemic
    ○ Antibiotics/pain relief
  3. Topical
    ○ Flushing wounds
    ○ Antiparasitics (care, all can be toxic. No IVERMECTINS in turtles)
    ○ Dressings
    Few products registered for use in reptiles
  4. Environmental
    ○ Remove the cause
    ○ Parasite control
    Review husbandry
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25
Q

What are important factors in prevention of reptile skin conditions

A
○ Correct POTZ range 
○ Appropriate heat source and UVB type for species 
○ Furnishings to assist ecdysis 
○ Safe stocking rates 
○ Dedicated hygiene 
§ Cleaning substrate 
§ Ventilation 
§ Filtration 
○ Quarantine and mite prevention 
○ Balanced diet and supplements appropriate to species
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26
Q

How many mammary gland paris are present in rabbits, ferrets, guinea pigs, rats and mice

A
Rabbits -> 4 
Ferrets -> 4
Guinea pigs -> 1 
Rats -> 6
mice -> 5
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27
Q

Rabbits what is special about skin

A
  • Fastidious and mutual groomers
  • Seasonal moult
  • Females line nest with hair
  • Glands under chin and inguinal pockets
  • Haired pinnae
  • Two areas in ears to examine
  • No foot pads
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28
Q

Ferrets what is special about their skin

A
  • Very thick skin!
  • Seasonal alopecia
  • Haired pinnae
  • +++ sebaceous glands
  • 2x perianal scent glands
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29
Q

Guinea pigs what is special about their skin

A
  • Short, long, whorled hair
  • Glands over the rump and around the anus
  • Non-haired pinnae
  • Need dietary vitamin C
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30
Q

Rabbit what are the 4 main ectoparasites, clinical signs and diagnosis/treatment for all

A

1) Fur mite – Cheyletiella parasitovorax - waling dandruff, mild pruritis and alopecia
2) Fur mite – Leporacarus gibbus - salt and pepper look
3) Ear mite – Psoroptes cuniculi - crusty exudate in ear, intensely pruritic and painful
4) Rabbit fleas (and cat and dog fleas) - pruritis
Dx -> sticky tape prep
Tx -> selamcentin (revolution) - advantage for flea
NO FIBRONIL IN RABBITS

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31
Q

Guinea pigs what are the 2 main ectoparasites, clinical signs, diganosis and treatment

A
1) fleas - pruritis, dull coat, patchy alopecia
Dx - visualisation, flea dirt
2) scabies - pruritis and alopecia 
Dx - deep skin scrap, clinical signs 
Tx -> both selamectin (revolution)
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32
Q

Ferrets what are the 3 main ectoparasites, clinical signs, diagnosis/treatment

A
1) Sarcoptic Mange “Foot rot” - alopecia, intense pruritus, pain, nails can slough
Dx - deep skin scrap 
Tx - ivermectin 
2) Ear mite – Otodectes cyanotis - head shake, scratch, pruritis 
Dx - smear
Tx - adovate (moxidectin)
3) Fleas (Dog & Cat)
Dx - visualisation
Tx - advantage (imidacloprid)
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33
Q

Mice and rats what are the 3 main ectoparasites, clinical signs, diagnosis and treatment

A

1) Fur mites (multiple species) - greasy pruritic dermatitis, ulceration
Dx - sticky tape prep
Tx - ivermectin
2) Fleas (Dog, Cat, Wild rodent fleas) - dull coat
Dx - visualisation
Tx - frontline (fibronil)
3) Lice (Pediculosis) - weight loss, alopecia
Dx - exclusion and treatment trail
Tx - ivermectin

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34
Q

Bacterial dermatitis/pyoderma in rabbits location, bacterial, clinical signs and treatment

A
  • Common in areas where moisture can build up
  • S. aureus mostly, but can be variety of bacterial aetiologies
    Clinical signs
  • Moist, exudative lesions
  • Ulcerative lesions
  • Folliculitis
  • Secondary ileus (reduced or absent gut sounds)
    Treatment
  • Clip and clean through to surgical debridement
  • Barrier creams and topical antibiotic creams through to systemic antibiosis and analgesia
    ○ Beware of secondary dysbiosis
    Avoid corticosteroid based preparations - NEVER
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35
Q

Bacterial dermatitis/pyoderma in ferrets/guinea pigs/ rats and mice how generally ocurr, bacteria, clinical signs, treatment

A
  • Usually secondary to skin trauma (bite/fight/selfinflected)
  • Staphs and streps usually, but can be a number or bacterial aetiologies
    Clinical signs
  • Superficial exudates and crusting
  • Ulcerative lesions
  • Folliculitis
  • Furunculosis
  • Anorexia and lethargy depending on severity of disease
    Treatment
  • Topicals (inc shampoos) for milder cases
  • Systemic antibiosis for more severe cases
    Beware of secondary dysbiosis in Guinea Pigs
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36
Q

Abscesses in small mammals what result from, where located, clinical signs, diagnosis and treatment

A
  • Usually the result of fight wounds, trauma, injection sites, surgical incisions, sometimes haematogenous or lymphatic spread
  • If around the face, consider dental disease in all species
    Clinical signs
  • soft swelling +/- discharging sinus
  • Can be pyrexia, anorexia and depression
  • Rabbit pus is very thick and caseous
    Diagnosis
  • Via FNA could also culture
    Treatment
  • Surgical excision as complete mass
  • Alternative, lancing, debridement, +/- drain placement and antibiotic impregnated gel or beads into abscess site
  • Cover with broad spectrum antibiotics initially
  • Analgesia
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37
Q

Fungal dermatopathies what mammals susceptible, causes, importance, clinical signs, diagnosis and treatment

A
  • All species are susceptible, though less common in indoor pets
  • Is usually a Microsporum or Trichophyton
    ○ Microsporum fluoresces under sustained UV light
  • Have zoonotic potential
    Clinical signs
  • Circular crusting lesions with central alopecia
  • +/- pruritis
  • Can be anywhere on the body
    Diagnosis
  • Woods lamp test (only useful if Microsporum)
  • Fungal culture
    Treatment
  • Localised spots can be treated with topicals (ie, Canesten creams)
  • Systemic antifungals – check texts for appropriate options
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38
Q

Neoplasia what type common in rabbits, ferrets, guinea pigs and rodents

A
  • Rabbits – none specifically more common
  • Ferrets – mast cell tumours common
  • Guinea pigs – trichofolliculoma
    ○ Benign basal cell epithelioma, surgical excision usually curative though not always needed as not likely to metastasise and rarely locally invasive
  • Rodents – Mammary neoplasia
    ○ Mice = malignant (usually) - not a good prognosis
    ○ Rats = benign
    ○ Both sexes can be affected
    ○ Vast distribution of mammary tissue means they can be almost anywhere on the body
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39
Q

injection site reaction what vaccine must susceptible, clinical signs, treatment and prevention

A
- Cylap RCD intradermally - rabbit calicivirus 
Clinical signs 
- Hair loss
- Ulceration
- Abscess
Treatment– supportive
Prevention
- Use new needle to give
- Ensure is SQ
- Massage!
• OHS – do not inject yourself. If you do seek medical attention immediately.
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40
Q

Rabbit diseases otitis externa what generally secondary to, results in and clinical signs

A
  • Mite driven -> secondary to Psoroptes cuniculi (ear bites)
  • Purulent discharge and wax found in the ears of many bunnies without overt clinical signs - differentaite wax and pus with cytology
  • Otitis media with a ruptured tympanic membrane can result in pus in the external canal
    Clinical signs
  • Pruritus, head shaking, ear scratching
  • visible pus on otoscopic examination
  • Vestibular signs if middle ear affected
  • Can be concurrent ear mite infestation
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41
Q

Otitis externa for rabbits diagnosis and treatment

A

Diagnosis
- Based on c/s and cytological evidence of infection - see the mites
- Imaging to assess for concurrent middle ear disease
Treatment
- ANALGESIA!
○ Avoid corticosteroid based therapies
- If electing topicals, need to clean out ear canal under GA first, as wax will impede activity of medications
○ If tympanic membrane is ruptured, avoid topicals and start empirical therapy with penicillin SQ
- With concurrent middle ear disease, base ongoing therapy on C&S
- Surgery possibly an option

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42
Q

Ulcerative pododermatitis in rabbits what is it, clinical signs and diagnosis

A
  • Severe condition of the hocks, predisposed by inappropriate cage substrates
  • Is a pressure sore (avascular necrosis) of the hock and associated structures.
    Clinical signs
  • Ulcerative lump on foot
    Diagnosis - via clinical signs and imaging (to see if the bone is involved)
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43
Q

Ulcerative pododermatitis in rabbits treatment

A
  • Correct the substrate (dry grass is ideal!) early in disease - prevention
  • Bandages which distribute weight away from the hock/ulcer site
  • Antibiotics (based on C&S ideally) and analgesia
  • Rarely surgery, but can be salvage procedures
  • Euthanasia
44
Q

Myiasis in rabbits, what is it, what is required and clinical signs

A

Fly strike (Myiasis)
- Usually requires soiled or persistently wet skin to attract flies
Clinical signs
- Strike site typically between tail and dorsum - diagnosed based on clinical signs
- Secondary ileus (reduced or absent gut sounds)

45
Q

Fly strike in rabbits treatment and management

A

Treatment
- Stabilisation for the critically unwell patient
- Sedation or anaesthesia (with analgesia!)
- Physical removal of maggots and debriding of affected tissue
- Antibiotics and ongoing analgesia
- Manage the secondary ileus - important - NEED TO GET THEM EATING AGAIN
Management
- Correct any underlying grooming issues or causes for soiling (dental disease, overweight, arthritis)
- Maximise hutch hygiene and apply fly wire to hutch

46
Q

Myxomatosis in rabbits, what results in, transmission, clinical signs, diagnosis and treatment

A
  • 100% mortality rate of clinically affected rabbits
  • Incubation of 8-21 days
  • Biting insect vector
  • Virus replicates at inoculation site -> disseminates via leucocytes to skin, spleen, lymph nodes, mucosal surfaces, testes, lungs, liver
    Clinical signs
  • Swollen eyelids, genitalia, ears, face
  • Pyrexia
  • Depression and anorexia
  • Deaths within 14 days from secondary septicaemia
    Diagnosis – based on clinical signs
    Treatment – euthanasia is the only humane option
47
Q

Treponematosis what is it, transmission, clinical signs, diagnosis and treatment

A

(Rabbit syphilis)
- Sexually transmitted spirochete that infects offspring during birthing process
- Not really seen in Austalia
- Can be carriers if not symptomatic
Clinical signs
- Lesions at mucocutaneous junctions (nose, lips, eyelids, genitalia)
- Starts as erythema and oedema -> papules -> ulcerated nodules with exudative serum àcrusty scabbed lesions
Diagnosis
- skin biopsy and special silver staining
- serological test available in the UK - not in Australia so cannot diagnose
Treatment
- Procaine penicillin G subcutaneously once weekly until signs resolved
- DO NOT GIVE PPG ORALLY!

48
Q

Ferret canine distemper virus mortality rate, prevented with and transmission

A
  • 100% mortality rate typically within 21-35days after exposure
  • 100% preventable by vaccination – give 1/3 of a C3 vaccination for dogs
  • Direct contact, fomites and aerosols can transmit it
49
Q

Ferret canine distemper virus clinical signs, diagnosis, treatment

A
Clinical signs 
- Conjunctivitis and rhinitis initially
- Pyrexia
- Mandibular and inguinal rash
- Hyperkeratotic lesions of the nose and foot pads with brown crusting
- Neurological signs prior to death
Diagnosis – can do serum antibody titres
Treatment – euthanasia is only humane option
50
Q

Alopecic syndrome in ferrets what are the two main ones and their cause

A

1) hyperoestrogenism (female) - persistent oestrus- need to be mated
2) adrenocortical disease (male) - early neutering, increased adrenal cortex, stimulation by FSH and LH, overproduction of androgens and oestrogens

51
Q

Hyperoestrogenism in female ferrets clinical signs, diagnosis and treatment

A

Clinical signs - swollen vulva, weight loss and lethargy, bilaterally symmetric alopecia
diagnosis - low PCV and pancytopenia
Treatment - spey prior to oestrus, mate to vasectomised male

52
Q

Adrenocortical disease in male or female ferrets clinical signs, diagnosis and treatment

A

CS - Swollen vulva (F)
Urethral obstruction (M)
Weight loss and lethargy
Bilaterally symmetric alopecia
D - low PCV and pancytopenia, adrenal mass
Treatment
Surgical - not without potential complication - can lead to haemorrhage
can be curative
Medical - Deslorelin implant (GnRH agonist)

53
Q

Hypovitaminosis C in guinea pigs what is the requirement, how receive, definciency leads to, clinical signs, diagnosis and treatment

A
  • Absolute requirement of 10mg/kg/day
  • Should source vitamin C from fresh fruits and vegetables
  • Deficiency predisposes to range of infectious disorders
    Clinical signs
  • Rough coat with scaley pinnae
  • Ecchymoses, petechiae and haematomas
  • Painful and swollen joints
    Diagnosis – not really necessary, just supplement
    Treatment – correct the diet and supply 50-100mg/kg/day during initial phase of dietary correction
54
Q

Cervical lymphadenitis in guinea pigs what is it, result from, clinical signs, diagnosis, treatment and prognosis

A
  • Abscessation of the cervical lymph nodes
  • Oral trauma/abrasion -> inoculation with Streptococcus zooepidemicus (or other bacterial aetiology) -> invasion of the cervical lymph nodes àabscess.
    Clinical signs
  • Ventral neck swelling with thick caseous exudate
  • Secondary signs suggestive of septicaemia
    Diagnosis
  • FNA reveals suppurative inflammation with cocci
  • C&S (include abscess capsule!)
    Treatment
  • Surgical removal of abscessed lymph node
  • Systemic antibiotics
  • Pain relief!
    Prognosis – usually good
55
Q

Pododermatitis with guinea pigs predisposition and clinical signs

A
Predispositions –
- Wire flooring
- Unsanitary conditions
- Obesity
- Vitamin C deficiency
Clinical signs 
- Anorexia, lethargy with lameness and increased vocalisation
- Erythema and alopecia of foot pads
- Erosions and ulceration
- Secondary abscessation, osteomyelitis and sepsis
56
Q

Pododermatitis in guinea pigs diagnosis and treatment

A

Diagnosis
- C/s, FNA of the area will reveal pyogranulomatous inflammation
- Imaging recommended
Treatment
- Correct the predispositions
- Dressings
- Topical ointments (eg. Silver sulfadiazine)
- Supplement vitamin C
- Systemic antibiotics based on C&S results (Beware dysbiosis - death if wrong antibiotic)
- Amputation
- Euthanasia

57
Q

Ovarian cysts in guinea pigs when common, clinical signs, diagnosis and treatment

A
  • Common in entire females of 2-4yo
    Clinical signs
  • Lethargy and anorexia
  • Non-pruritic
  • +/- Bilaterally symmetric alopecia if functional cysts
  • Abdominal distension with palpable cystic structures in the dorsocranial abdomen
    Diagnosis
  • C/s and palpation of the classical cystic lesions in the abdomen
  • Ultrasonographic/radiographic evidence of ovarian cysts
    Treatment – OHE - ovariohysterectomy
  • Usually concurrent uterine changes
  • Hair will typically regrow once speyed
58
Q

what is important in the physical examination for eye issues in small mammals

A
- Any asymmetries present?  - important 
○ Exophthalmus
- Menace, PLR’s, following objects
- Eyelid abnormalities
- Punctum lacrimale in rabbits - need to look 
- STT
- Topical anaesthetic application
- Fluorescein
○ Uptake anywhere
○ Check nostrils
- Mydriasis
○ Tropicamide for rabbits
○ Beware toxicities - dilute the dosage 
- Dental examination
59
Q

Conjunctivitis +/- corneal ulceration in any mammal what are some causes, clinical sign, diagnosis and treatment

A
  • Primary - infectious origin
  • Secondary to trauma, poor hygiene and ventilation, systemic illness, dental disease, tear film abnormalities
    Clinical signs
  • Hyperaemic conjunctiva +/- oedema
  • Blepharospasm
  • Epiphora
  • +/- cloudy opacity to the cornea
    Diagnosis
  • Complete ocular examination (Fluorescein especially)
  • Assess nasolacrimal duct drainage
    Treatment
  • Topical ointments (avoid ones with c’steroids in rabbits and guinea pigs)
    ○ Be mindful of potential toxicities for smaller patients
  • Ulcer debridement, systemic anti-inflammatories +/- antibiotics
  • Monitor once-twice weekly
60
Q

Rabbit epiphora and dacryocystitis what are 3 common causes and clinical signs

A

○ Primary pasteurellosis
○ Blocked passage of nasolacrimal (NL) duct is common cause
○ Maxillary root elongation and periapical infections of tissue/bone/secondary lacrimal gland
Clinical signs
- Tear spillage over medial canthus +/- localised dermatitis
- Pain on palpation just ventral to medial canthus
- Purulent material in the eye or expressed through punctum lacrimale
- Swollen lacrimal sac

61
Q

Rabbit Epiphora and Dacryocystitis diagnosis and treatment

A

Diagnosis
- STT > 11mm/min and other C/s
- Dental assessment including imaging
- Consider cytology and C&S of purulent material
Treatment
- Clip & clean facial dermatitis area (+/- under sedation/GA) then topical barrier cream around area of dermatitis +/- ophthalmic preparations
- As per conjunctivitis with NL duct flush (see notes for description)
- Consider systemic antibiotics
- Definitely pain relief

62
Q

Encephalitozoon cuniculi in rabbits transmission, clinical signs, diagnosis and treatment

A
  • Can be asymptomatic carriers
  • Speculated to be vertically acquired in utero
    Clinical signs
  • More commonly head tilt and neuro signs, renal signs
  • If ocular, then unilateral disease usually with cataract formation
  • Can see spontaneous lens rupture
  • Iris abscess, hypopyon possible
  • Acute uveitis (hyperaemic iris) with progression to chronic indicated by synechia or glaucoma
    Diagnosis - challenging! -> as already exposed so antibodies doesn’t help, if suspicious just treat
    Treatment
  • Fenbendazole for 30 days to kill parasite
  • Symptomatic treatment for inflammatory response - NSAIDS
63
Q

Prolapse conditions what are the 2 main ones in rabbits what results in and treatment

A

1) Third eyelid deep gland prolapse
○ Similar to ”Cherry eye” in dogs
○ Looks more severe
○ Surgical reduction is possible
○ May need surgical excision, but avoid if possible as can cause secondary tear film disturbances
2) Retrobulbar disease/Exophthalmus
○ Similar process to other species (especially dental disease)
○ By the time of presentation, is late in disease process.
○ Usually requires enucleation
○ Always cover with antibiotics and pain relief
○ Treat underlying cause

64
Q

What are the 5 main ferret eye diseases

A
  1. Canine Distemper Virus – as per skin slide
  2. Human Influenza - Conjunctivitis
  3. Cataracts – inherited/congenital/acquired/incidental
    ○ Control secondary uveitis +/- phaecoemulsification
  4. Retinal degeneration – think dogs
  5. Exophthalmus (think lymphoma!)
65
Q

Exophthalmus in ferrets what result in, cause, diagnosis and treatment

A

○ Usually very progressed disease at presentation
○ Exposure keratitis occurs
○ Can get lymphoma in retrobulbar location prior to systemic signs
○ Full systemic testing required to rule out lymphoma
○ Can get retrobulbar abscesses/foreign bodies which would typically have more pain appreciable than with lymphoma
○ Enucleation often required

66
Q

What are the 4 main guinea pig ocular diseases

A
  1. Foreign body conjunctivitis and ulceration
    ○ Remove the foreign body and treat as per standard corneal ulcer principles
  2. Chlamydial conjunctivitis
    ○ PCR (Chlamydia caviae)
    ○ Tetracycline based ophthalmic preparation
  3. Congenital deformities
  4. Heterotropic bone formation
    ○ Vitamin C mediated
    ○ Deposition of calcium into the aqueous humour and calcification at the limbus
    ○ No treatment required usually
67
Q

Rodent ocular disease what are the 2 main ones, cause, clinical signs and treatment

A
  1. Chromodacryorrhoea
    - Red tears
    - Can be from nostrils and on front legs from grooming
    - Induced by porphyrin pigment in rodent tears that is produced during stressful times
    - No treatment specifically
  2. Conjunctivitis secondary to Upper Respiratory Tract Disease
    - Classical signs as per other species + sneezing and red tears
    - Consider PCR for mycoplasma diagnosis
    - Treatment is symptomatic
68
Q

Rabbit what is special about their upper and lower respiratory tract anatomy

A

Upper respiratory anatomy
- Obligate nasal breathers
- Narrow oropharynx
- Glottis is small and difficult to visualise from the oral cavity
Lower respiratory anatomy
- Thorax in a rabbit is small compared to abdominal contents
- Thymus persists throughout life
- Thin pleural
No septum dividing lungs -> once get disease here spreads easily

69
Q

Rabbit rhinitis/sinusitis clinical signs and differential diagnosis

A
- Clinical signs 
○ Sneezing +/- discharge 
○ Staining around nares 
○ Stertor/snore 
○ Open mouth breathing 
- Differential diagnosis 
○ Trauma 
○ Foreign bodies 
○ Dental diseases - secondary to maxillary tooth root overgrowth 
○ Infections - bacterial most common - pasturellosis, mycoplasma, pseudomonas, Bordetella (generally no clinical disease)
○ Inflammatory diseases 
○ Neoplasia 
○ Other masses  - around head and neck that place pressure and constrict upper airway
70
Q

Rabbit rhinitis/sinusitis 4 diagnostic techniques and treatment

A

Diagnostic testing
a. Imaging
§ radiographs - lots of superimposition so need multiple x-rays
§ CT - best
§ Endoscopy - can be useful
b. Culture and sensitivity
§ Deep nasal swabs and nasolacrimal duct flushes collection
§ Looking for predominant overgrowth of one organism
c. Biopsy
d. Bloods - haematology and biochemistry -> tend not to get increase so not as helpful
Treatment
○ Primary medical management - flush when can, antibiotics based on culture and sensitivity
○ Surgical debridement

71
Q

What is important with emergency stabilisation for rabbits

A

Emergency stabilisation - place in dark, quite room to reduce stress with supplementary oxygen and minimise handling for 30mins

72
Q

Rabbit intrathoracic respiratory disease clinical signs and differential diagnosis

A
- Clinical signs 
○ Difficulty breathing, open mouth breathing, increased respiratory rate, wheezes, crackles 
- Differential diagnosis 
○ Secondary to URT 
○ Trauma and foreign bodies 
○ Primary respiratory disease 
§ Infection 
§ Inflammatory 
§ Neoplasia - below 
Other intrathoracic disease
73
Q

Pasturellosis how common in rabbits, transmission, zoonotic and what affects the disease

A
  • Gram -ve bacterium - most common cause of respiratory disease in rabbits
  • Commensal
  • Transmission - nasal, oral fomites, vertical
  • Very rarely may be zoonotic
  • Course of disease varies with
    ○ Strain virulence
    ○ Host immune response
    ○ Additional stressors
74
Q

Thoracic neoplasia of rabbits what are some common ones

A
  • Lower respiratory disease the only primary neoplasia is pulmonary carcinoma
    ○ HOWEVER lymphosarcoma may affect lungs and mediastinal lymph nodes
  • Lungs are the most common site for metastases
    ○ Female entire rabbits usually secondary to uterine adenocarcinoma
  • Thymoma and malignant thymic lymphomas
75
Q

Cardiac disease in rabbits anatomic consideration and history

A
  • Anatomic considerations
    ○ Rabbit thorax small in consideration to the rest of its body
    ○ The mediastinum in normal rabbits contains fat
    ○ The left AV valve is tricuspid rather than bicuspid
  • History
    ○ Dyspnoea, tachypnoea (normal RR 30-60bpm) but can increase with stress), syncope and cyanosis
    ○ Non-specific signs
    Signs may be hidden until disease has reaches serious stage
76
Q

Cardiac disease in rabbits clinical signs and diagnostic tests

A
- Clinical signs 
○ Pallor, cyanosis, muffled heart sound, tachycardia (normal 150-300bpm), murmur, gallop rhythm, crackles and weak pulses 
○ Coughing NOT COMMON 
○ Rarely: R sided heart failure may result in exophthalmos
- Diagnostic tests 
○ Radiology 
○ Electrocardiography 
○ Echocardiography
77
Q

Cardiac disease in rabbits what are the 2 main ones, what caused by and treatment options

A
  1. Chronic AV valve disease - endocardiosis
    - Older rabbits
    - Mitral more common than tricuspid
  2. Cardiomyopathies (rare)
    - Nutritional deficiencies, infectious diseases, toxins or stress
    - Dilative, hypertrophic or restrictive
    Treatment: frusemide, pimobendane, ace-inhibitors
78
Q

Guinea pigs oral anatomy what is different

A
  • Detention angles inwards so harder to visualise the oral cavity
  • Long soft palate
  • Platational ossium (larynx is hidden away within - need scope)
  • Prone to respiratory infections
  • Nasal obligate breather
  • Thymus surrounds the trachea
79
Q

Guinea pigs respiratory disease predisposing factors and clinical signs

A
  • Predisposing factors
    ○ Vitamin C deficiency - keep teeth embedded within - if not then infection - predispose to respiratory disease
    ○ Husbandry issues - ventilation and toxic ammonia build up
    ○ Gradients, cold or hot weather, dusty environment
  • Clinical signs of bacterial pneumonia in guinea pigs
    ○ Anorexia, ocular and nasal discharge, abnormal respiratory sounds (wheezing, gurgling), lethargy and sneezing
    ○ May progress to tachypnoea and or dyspnoea
80
Q

Guinea pig respiratory disease what are the 4 main differential diagnosis and things within

A

○ Infectious
§ Bordetella (rabbit harbour this bacteria so don’t house together)
§ Adenovirus - sudden death
§ Fungal - less common
○ Inflammatory
§ Allergic suspected
○ Neoplastic
§ Primary respiratory adenocarcinoma
§ Metastatic mammary neoplasia - RARE
§ Lymphosarcoma and leukemia leading to dyspnoea as affect mediastinal lymph nodes
○ Diseases affecting other systems - heat stress, pain

81
Q

Pulmonary neoplasia what is the main one in guinea pigs and prevalence

A

○ Bronchogenic papillary adenoma is the most common

§ Prevalence of 35%

82
Q

Ferrets respiratory anatomy, respiratory rate, lung capacity and clinical signs of respiratory disease

A
  • Obligatory nasal breathers due to close apposition of the epiglottis to the soft palate
  • Normal respiratory rate at rest is 33-36bpm
  • Large lung capacity
  • Chest wall is very compliant
  • Ferrets exhibit neurogenic inflammation when sensory nerve stimulation causes a release of tachykinins (viral diseases and airborne toxins eg nicotine) can cause this response
    Clinical signs of respiratory disease:
  • Photophobia, cattarhal nasal discharge, sneezing, coughing, pyrexia, anorexia and malaise
83
Q

Respiratory disease in ferrets what are the 4 main ones

A

1) influenza
2) pneumonia
3) distempter
4) dental disease can cause URT signs

84
Q

Influenza in ferrets which influenza, clinical course, what may progress to and treatment

A

○ Only domestic species naturally responsive to human influenza
○ Clinical course 7-14 days
○ May progress to pneumonia
○ Treatment: supportive care, antihistamines, cough suppressants and prophylactic antibiotics

85
Q

Pneumonia in ferrets what most common cause, other causes and treatment

A

○ Aspiration is suspected to be the most common cause
○ Other bacterial causes eg. B. bronchispetica, P. multocida, Mycoplasma spp.
§ B. bronchispectica vaccination possible
§ Separation of young ferrets from dogs is recommended
○ Treatment: antibiotics, supportive care, antihistmaines (eg diphenhydramine helps with nasal congestion if present)

86
Q

Distempter in ferrets disease progression, transmission, early and later signs

A

○ Fatal in ferrets - VACCINATE FOR
○ Disease progression 12-42 days depending on the strain
○ Transmission through direct contact, fomites or aerosolization of feces, urine or nasal exudate
○ Early signs: anorexia, pyrexia, photophobia, chin dermatitis, nasal and ocular discharge
○ Later signs: bronchopneumonia, hyperkeratosis around nasal planum and footpads then CNS signs including tremors, convulsions and death

87
Q

Ferret cardiac disease how common, normal HR, clinical signs and diagnostics

A
  • COMMON
  • Heart more caudal
  • Normal HR = 180-250bpm
  • Clinical signs - exercise intolerance, dyspnoea, weakness, pallor with prolonged CRT
  • Diagnostics - radiograph and echocardiography
88
Q

Ferret cardiac disease what are the 4 main ones

A

1) cardiomyopathy
2) valvular heart disease
3) heartworm disease
4) metabolic disease can manifest

89
Q

Cardiomyopathy in ferrets what age common in, what type most common and treatment

A

○ most common in middle age to older ferrets
○ Dilated most common but also see hypertrophic
§ Characterised with increase diastolic dimension of left and right ventricles
§ Treatment same as rabbits

90
Q

Valvular heart disease in ferrets how common, what type and what metabolic disease manifests as cardiac disease

A

Valvular heart disease
○ Endocardiosis is the second most common form of heart disease in ferrets
○ Mitral valve appears most affected followed by tricuspid and aortic
○ Echocardiology is used to differentiate mitral valve endocardiosis from DCM
§ Increased or normal fractional shortening and contractility occur in endocardiosis and are reduced in DCM.
Metabolic disease can manifest as cardiac disease:
○ Hypoglycaemia from insulinoma, liver disease or fasting can cause bradycardia
○ Functional phaeochromocytomas may cause increased heart rate, blood pressire and weakness

91
Q

Heartworms disease in ferrets diagnosis, preventative medication, clinical signs and treatment

A

○ Low transient levels of microfilaria
○ ELISA based antigen tests (IDDEXX snap tests are effective 5-6 months after infection but may be negative due to low numbers of adult heartworm
○ Adult heartworm may be seen by ultrasound 5 months after infection in CVC or right side of heart
○ Preventative medication: selamectin, ivermectin, moxidectin
○ Clinical signs similar to dogs: coughing, dyspnea, tacchypnea, pleural effusion, ascites
○ Adulticide:
§ single dose of moxidectin (Proheart) at 0.1ml/ferret sc has been used safely and effectively
§ melarsomine can cause severe reactions (incl. death)

92
Q

Rodents what is the main thing that is special about respiratory anatomy. clinical signs and 2 main predisposing factors for respiratory disease

A
Comparative respiratory anatomy
- Obligate nasal breathers
Clinical signs:
- Nasal discharge, ocular discharge, clicking/snuffling, dyspnea, cyanosis, open mouth breathing, head tilt (vestibular involvement), signs of general malaise
Predisposing factors to respiratory disease - HUSBANDRY 
1. High ammonia levels in enclosure due to
○ High stocking density
○ Poor ventilation
○ Inadequate hygiene
2. Air pollution
○ Dust
○ Fungal spores
○ Disinfectant vapours
○ Pollutants
93
Q

Rodent respiratory disease what are the 2 main causes and causes within and diagnostic tests used

A
  1. Infectious:
    - Bacterial:
    ○ Mycoplasma pulmonis (major pathogen in rats)
    ○ Bordatella bronchiseptica
    ○ Chlamydophila
    - Viral:
    ○ Hantavirus
    ○ Sendaivirus (major pathogen in adult mice)
    - Fungal: pnuemocystosis
  2. Non-infectious:
    ○ Allergic
    ○ Aspiration
    ○ Neoplasia
    Diagnostic testing (size can be a limiting factor here):
  3. Microbiology – culture and sensitivity - prone to contamination - looking for overgrowths
  4. Imaging – xray, CT
94
Q

Mycoplasma pulmonis pneumonia in rats how common, transmission, causes, possible results

A
  • Most common respiratory pathogen in rats
  • Transmission via direct contact, aerosolization and transplacentally - MOST RATS EXPOSED EXCEPT FOR SCIENTIFIC FREE
  • Usually sets up a persistent infection
  • Causes:
    ○ Acute: tracheobronchitis or pneumonia
    ○ Chronic: airway inflammation, bronchiectasis
    ○ Sometimes middle ear infection
  • Like asthma - potentiates neurogenic infection - get hypersensitivity
  • Like chronic bronchitis - ongoing pulmonary infeciton
  • Biofilm created allows bacterial colonisation
95
Q

Rodent respiratory disease what are the 6 main treatments needed

A
  1. Supportive care (oxygen, fluids, nutritional, pain relief)
  2. Antimicrobials
    ○ Doxycycline (anti-inflammatory action and penetrates the biofilm)
    ○ Amoxycillin/clavulanic acid
    ○ Enrofloxacin in combination with doxycycline
    ○ Azithromycin
  3. Bronchodilators (can be given orally or nebulised) – oral dose theophylline concurrently with enrofloxacin then reduce the theophylline dose by 30% asmetabolism is inhibited by fluoroquinolones
  4. Nebulisation (small particle size <3um) with
    ○ bronchodilators (aminophylline)
    ○ mucolytics (acetylcysteine)
    ○ mucokinetics (hypertonic saline 9% for 15 minutes twice daily)
  5. Anti-inflammatories
    ○ Meloxicam
  6. Environmental management - important - good ventilation and husbandry
96
Q

Reptile cardiovascular anatomy how many chamber heart, position within, HR (how to detect)

A
  • 3 chambered heart (incomplete interventricular septum) in lizards, snakes and chelonians
    ○ 4 chambered heart in crocodilians
  • Position of the heart within the coelom varies:
    ○ Snake ¼ - 1/3rd body length
    ○ Chelonians – cranial coelomic cavity
    ○ Lizards vary eg bearded dragons (cranial) vs monitor lizard (further caudal)
  • Heart rates in reptile lower and vary with: temperature, oxygen saturation in blood, respiratory ventilation, stress
  • Auscultation with doppler or stethoscope and wet towel - ESPECIALLY TURTLES
97
Q

Reptile heart clinical signs, diagnostic testing and treatments

A

Clinical signs: enlarged heart, non-specific signs (weight loss, lethargy), cyanosis, or abnormal auscultation
Diagnostic testing:
1. Haematology and biochemistry
2. Imaging: radiology, echocardiology, ECG
Treatments:
- Depends of the underlying aetiology but anecdotal reports exist of the use of diurectics (furosemide) and ACE-I (benazepril)

98
Q

Reptile respiratory anatomy why hard to intubate, diaphragm, respiration varies with

A
  • Blocked nares can cause stridor
  • Glottis closed at rest - easy to intubate
  • Breath holding can be prolonged - don’t want to mask down a reptile
  • Inability to cough making some species prone to lower respiratory tract disease
  • No diaphragm – air is inspired by negative pressure breathing
  • Respiration varies with
    ○ temperature (not carbon dioxide)
    ○ physiological or behavioural reasons which may result in increased respiration (stress)
99
Q

Reptile lungs how many chambers, where located in turtle, snake what important

A

○ Single chambered in snakes and some lizards
○ Multichambered in monitor lizards, chelonians and crocodilians
○ Chelonia: lungs sit dorsally just below carapace
○ Snakes:
§ One functional lung (right) in most snakes with left lung vestigial or absent
§ Pythons and boas being more primitive snakes have 2 lungs

100
Q

Respiratory disease in reptile how common, what predisposed by and main clinical signs

A
  • COMMON IN REPTILES
  • Predisposed via HUSBANDRY
  • Clinical signs of respiratory disease
    ○ Nasal discharge (with URT disease), increased respiratory noise/effort, glottal swelling, open mouth breathing, constant gaping, signs of general malaise.
101
Q

Reptile respiratory infectious causes what are some

A
  • Bacterial: eg Mycobacteria, Mycoplasma, Chlamydia, Pseudomonas, Aeromonas, Klebsiella, E. coli
  • Viral
    ○ Paramyxoviruses - the first 2 listed below also show neurological signs
    ○ Ferlavirus (previously known as OPMV)
    ○ Sunshinevirus
    ○ Reovirus
  • Parasitic (note: Ivermectin is toxic to chelonians)
    ○ Flukes
    ○ Protozoa
102
Q

Sunschine virus location, transmission and main results

A
  • Detected in most states of Victoria
  • Transmission suspected via:
    ○ Horizontal: cloacal (fecal and cloacal secretions) and oral (aerosol) routes
    ○ Vertical: not confirmed (viral positive embryos have been tested but no virus has been detected from hatchlings – possibly self-limiting in that affected embryos may not hatch)
  • Neurorespiratory disease
103
Q

Sunschine virus and ferlavirus what are the 3 main clinical signs categories and signs within, how to confirm

A
1. Neurological
○ Head tremors
○ Opisthotonus (star gazing)
○ Incoordination of front and back body
○ Diminished righting reflexes
○ Erratic gaping mouth
2. Respiratory
○ Mild discharge of clear viscous fluid from mouth
○ Dyspneoa
3. Non-specific
○ Lethargy
○ Anorexia
○ Stomatitis
○ Regurgitation
○ Weakness
○ Dermatitis
- Some snakes may carry and not have clinical signs 
CONFIRM - via viral PCR
104
Q

Reptiles diagnostic tests what are the 6 main ones

A
  1. History
  2. Physical exam
  3. Haematology/ biochemistry - systemic inflammation
  4. Microbiology (culture and sensitivity of tracheal swabs or BAL samples)
  5. Imaging (radiology, CT, endoscopy)
  6. Viral PCR (oral and cloacal swabs in viral transport media - available through Tim Hyndman at Murdoch University)
105
Q

Reptile respiratory disease what are the 3 main treatment options

A
  1. Husbandry assessment and improvement
  2. Supportive care
    ○ Oxygen
    ○ Fluids
    ○ Pain relief
  3. Antimicrobials if indicated: administered to animals at their preferred body temperature (minimum 4 week treatment) eg.
    ○ Enrofloxacin
    ○ Ceftazidimine
    ○ Metronidazole